Up‐regulation of HOXA‐AS2 and MEG3 long non‐coding RNAs acts as a potential peripheral biomarker for bipolar disorder
Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was t...
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| Published in: | Journal of cellular and molecular medicine Vol. 28; no. 21; pp. e70150 - n/a |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
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England
John Wiley & Sons, Inc
01.11.2024
John Wiley and Sons Inc |
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| ISSN: | 1582-1838, 1582-4934, 1582-4934 |
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| Abstract | Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA‐AS2 and MEG3 ncRNA transcripts. HOXA‐AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real‐time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA‐AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA‐AS2 and MEG3 compared to controls. The lncRNAs HOXA‐AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA‐AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA‐AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA‐AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD. |
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| AbstractList | Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non‐coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA‐AS2 and MEG3 ncRNA transcripts. HOXA‐AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real‐time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA‐AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA‐AS2 and MEG3 compared to controls. The lncRNAs HOXA‐AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA‐AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA‐AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA‐AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD. Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non-coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA-AS2 and MEG3 ncRNA transcripts. HOXA-AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real-time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA-AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA-AS2 and MEG3 compared to controls. The lncRNAs HOXA-AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA-AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA-AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA-AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD.Bipolar disorder (BD) is a psychiatric condition that is frequently misdiagnosed and linked to inadequate treatment. Long non-coding RNAs (lncRNAs) have lately gained recognition as crucial genetic elements and are now regarded as regulatory mechanisms in the neurological system. Our objective was to measure the quantities of HOXA-AS2 and MEG3 ncRNA transcripts. HOXA-AS2 and MEG3 ncRNA levels were checked in the peripheral blood of 50 type I BD and 50 control samples by real-time PCR. Furthermore, we conducted ROC curve analysis and correlation analysis to examine the association between gene expression and specific clinical characteristics in instances with BD. Additionally, a computational study was performed to investigate the binding sites of miRNAs on the HOXA-AS2 and MEG3 lncRNAs. BD subjects showed a significant increase in the expression of HOXA-AS2 and MEG3 compared to controls. The lncRNAs HOXA-AS2 and MEG3 have an area under the ROC curve (AUC) values of 0.70 and 0.71, respectively. There was a significant correlation between the expression levels of ncRNAs HOXA-AS2 and MEG3 in the peripheral blood of patients with BD and occupation scores. The data presented indicate a potential correlation between the expression of HOXA-AS2 and MEG3 lncRNAs with an elevated risk of BD. Furthermore, these lncRNAs may be linked to several molecular pathways. Our findings indicate that the amounts of lncRNAs HOXA-AS2 and MEG3 in transcripts might be a promising potential biomarker for patients with BD. |
| Author | Mokhtari, Mohammad Javad Hosseini, Maryam |
| AuthorAffiliation | 1 Department of Biology, Zarghan Branch Islamic Azad University Zarghan Iran |
| AuthorAffiliation_xml | – name: 1 Department of Biology, Zarghan Branch Islamic Azad University Zarghan Iran |
| Author_xml | – sequence: 1 givenname: Maryam surname: Hosseini fullname: Hosseini, Maryam organization: Islamic Azad University – sequence: 2 givenname: Mohammad Javad orcidid: 0000-0001-5066-9632 surname: Mokhtari fullname: Mokhtari, Mohammad Javad email: mj.mokhtari@iau.ac.ir organization: Islamic Azad University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39482996$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1007_s10528_025_11116_0 crossref_primary_10_1016_j_ejpsy_2025_100317 crossref_primary_10_3390_cells14141104 crossref_primary_10_1016_j_cca_2025_120265 crossref_primary_10_1007_s12672_025_03192_w |
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| SubjectTerms | Adult biomarker Biomarkers Biomarkers - blood Bipolar disorder Bipolar Disorder - blood Bipolar Disorder - diagnosis Bipolar Disorder - genetics Blood levels Case-Control Studies Correlation analysis Education Female Gene expression Gene Expression Regulation Humans LncRNA Male Marital status MicroRNAs MicroRNAs - blood MicroRNAs - genetics Middle Aged Neural coding Non-coding RNA Original Patients Peripheral blood real‐time PCR RNA, Long Noncoding - blood RNA, Long Noncoding - genetics ROC Curve Schizophrenia Software Thermal cycling Up-Regulation - genetics |
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| Title | Up‐regulation of HOXA‐AS2 and MEG3 long non‐coding RNAs acts as a potential peripheral biomarker for bipolar disorder |
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