IL-9 as a mediator of Th17-driven inflammatory disease

We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequ...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 206; no. 8; p. 1653
Main Authors:	Nowak, Elizabeth C, Weaver, Casey T, Turner, Henrietta, Begum-Haque, Sakhina, Becher, Burkhard, Schreiner, Bettina, Coyle, Anthony J, Kasper, Lloyd H, Noelle, Randolph J
Format:	Journal Article
Language:	English
Published:	United States 03.08.2009
Subjects:	Adoptive Transfer Animals Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Female In Vitro Techniques Inflammation Mediators - immunology Inflammation Mediators - metabolism Interleukin-9 - antagonists & inhibitors Interleukin-9 - biosynthesis Interleukin-9 - immunology Mice Mice, Inbred C57BL Mice, Knockout Receptors, Interleukin-9 - deficiency Receptors, Interleukin-9 - genetics Receptors, Interleukin-9 - immunology Spinal Cord - immunology Spinal Cord - pathology T-Lymphocyte Subsets - classification T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - classification T-Lymphocytes, Helper-Inducer - immunology
ISSN:	1540-9538, 1540-9538
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Summary:	We report that like other T cells cultured in the presence of transforming growth factor (TGF) beta, Th17 cells also produce interleukin (IL) 9. Th17 cells generated in vitro with IL-6 and TGF-beta as well as purified ex vivo Th17 cells both produced IL-9. To determine if IL-9 has functional consequences in Th17-mediated inflammatory disease, we evaluated the role of IL-9 in the development and progression of experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis. The data show that IL-9 neutralization and IL-9 receptor deficiency attenuates disease, and this correlates with decreases in Th17 cells and IL-6-producing macrophages in the central nervous system, as well as mast cell numbers in the regional lymph nodes. Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1540-9538 1540-9538
DOI:	10.1084/jem.20090246