Iron Deficiency Caused by Intestinal Iron Loss—Novel Candidate Genes for Severe Anemia

The adult human body contains about 4 g of iron. About 1–2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Genes Ročník 12; číslo 12; s. 1869
Hlavní autori:	Huettmann, Carolina, Stelljes, Matthias, Sivalingam, Sugirthan, Fobker, Manfred, Vrachimis, Alexis, Exler, Anne, Wenning, Christian, Wempe, Carola, Penke, Matthias, Buness, Andreas, Ludwig, Kerstin U., Muckenthaler, Martina U., Steinbicker, Andrea U.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Switzerland MDPI AG 24.11.2021 MDPI
Predmet:	Aged Aged, 80 and over Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - etiology Anemia, Iron-Deficiency - genetics Biopsy Bleeding Blood Bone marrow Chronic illnesses Cytokines diagnostic techniques Erythrocytes Erythropoiesis Erythropoiesis - genetics Excretion Families & family life Feces Female Ferritin Gastrointestinal Tract - metabolism Genetic diversity Genetic Variation - genetics Graphite Hemoglobin Hemorrhage - complications Hemorrhage - genetics Heredity Humans Intestine intestines Intravenous administration intravenous injection Iron Iron - blood Iron - metabolism Iron - urine Iron Deficiencies - etiology Iron Deficiencies - genetics Iron deficiency iron deficiency anemia liver Magnetic resonance imaging Male Middle Aged Mutation Mutation - genetics Nutrient deficiency Patients Plasma probability urine Germany genetically caused iron imbalance iron erythropoiesis intestinal iron loss red cells
ISSN:	2073-4425, 2073-4425
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	The adult human body contains about 4 g of iron. About 1–2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in CISD1 and KRI1) are likely to be functionally relevant. Intestinal iron loss in the current form has not yet been described and is, with high probability, the cause of the severe iron deficiency anemia in this patient.
AbstractList	The adult human body contains about 4 g of iron. About 1–2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in CISD1 and KRI1) are likely to be functionally relevant. Intestinal iron loss in the current form has not yet been described and is, with high probability, the cause of the severe iron deficiency anemia in this patient. The adult human body contains about 4 g of iron. About 1-2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in CISD1 and KRI1) are likely to be functionally relevant. Intestinal iron loss in the current form has not yet been described and is, with high probability, the cause of the severe iron deficiency anemia in this patient.The adult human body contains about 4 g of iron. About 1-2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in CISD1 and KRI1) are likely to be functionally relevant. Intestinal iron loss in the current form has not yet been described and is, with high probability, the cause of the severe iron deficiency anemia in this patient. The adult human body contains about 4 g of iron. About 1-2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with severe iron deficiency anemia with hemoglobin levels below 6 g/dL and ferritin levels below 30 ng/mL. Although red blood cell concentrates and intravenous iron have been substituted every month for years, body iron stores remain depleted. Diagnostics have included several esophago-gastro-duodenoscopies, colonoscopies, MRI of the liver, repetitive bone marrow biopsies, psychological analysis, application of radioactive iron to determine intact erythropoiesis, and measurement of iron excretion in urine and feces. Typically, gastrointestinal bleeding is a major cause of iron loss. Surprisingly, intestinal iron excretion in stool in the patient was repetitively increased, without gastrointestinal bleeding. Furthermore, whole exome sequencing was performed in the patient and additional family members to identify potential causative genetic variants that may cause intestinal iron loss. Under different inheritance models, several rare mutations were identified, two of which (in and ) are likely to be functionally relevant. Intestinal iron loss in the current form has not yet been described and is, with high probability, the cause of the severe iron deficiency anemia in this patient.
Author	Wempe, Carola Muckenthaler, Martina U. Buness, Andreas Sivalingam, Sugirthan Penke, Matthias Ludwig, Kerstin U. Huettmann, Carolina Steinbicker, Andrea U. Wenning, Christian Exler, Anne Vrachimis, Alexis Stelljes, Matthias Fobker, Manfred
AuthorAffiliation	12 Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany 4 Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany 2 Medical Clinic D: Hematology, Haemostaseology, Oncology and Pneumology, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; Matthias.Stelljes@ukmuenster.de 1 Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; carolina.huettmann@uni-muenster.de (C.H.); carola.wempe@ukmuenster.de (C.W.) 3 Core Unit Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; s.sivalingam@uni-bonn.de (S.S.); buness@uni-bonn.de (A.B.) 7 Department of Nuclear Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, German
AuthorAffiliation_xml	– name: 9 Institute of Human Genetics, University Hospital Bonn, Medical Faculty University of Bonn, 53113 Bonn, Germany; kerstin.ludwig@uni-bonn.de – name: 3 Core Unit Bioinformatics Data Analysis, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany; s.sivalingam@uni-bonn.de (S.S.); buness@uni-bonn.de (A.B.) – name: 8 Oncological Clinic, St. Franziskus Hospital, Franziskusstraße 6, 49393 Oldenburg, Germany; p.onkolohne@gmail.com – name: 5 Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany – name: 4 Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Venusberg-Campus 1, 53127 Bonn, Germany – name: 1 Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; carolina.huettmann@uni-muenster.de (C.H.); carola.wempe@ukmuenster.de (C.W.) – name: 2 Medical Clinic D: Hematology, Haemostaseology, Oncology and Pneumology, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; Matthias.Stelljes@ukmuenster.de – name: 11 Molecular Medicine Partnership Unit (MMPU), 69117 Heidelberg, Germany – name: 7 Department of Nuclear Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; Alexis.Vrachimis@goc.com.cy (A.V.); anne.exler@ukmuenster.de (A.E.); christian.wenning@hospital-lingen.de (C.W.) – name: 6 Center for Laboratory Medicine, University Hospital Muenster, University of Muenster, 48149 Muenster, Germany; Manfred.Fobker@ukmuenster.de – name: 10 Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, 69117 Heidelberg, Germany; Martina.Muckenthaler@med.uni-heidelberg.de – name: 12 Department of Anesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, 60590 Frankfurt am Main, Germany
Author_xml	– sequence: 1 givenname: Carolina surname: Huettmann fullname: Huettmann, Carolina – sequence: 2 givenname: Matthias surname: Stelljes fullname: Stelljes, Matthias – sequence: 3 givenname: Sugirthan surname: Sivalingam fullname: Sivalingam, Sugirthan – sequence: 4 givenname: Manfred surname: Fobker fullname: Fobker, Manfred – sequence: 5 givenname: Alexis surname: Vrachimis fullname: Vrachimis, Alexis – sequence: 6 givenname: Anne surname: Exler fullname: Exler, Anne – sequence: 7 givenname: Christian surname: Wenning fullname: Wenning, Christian – sequence: 8 givenname: Carola surname: Wempe fullname: Wempe, Carola – sequence: 9 givenname: Matthias surname: Penke fullname: Penke, Matthias – sequence: 10 givenname: Andreas orcidid: 0000-0003-1889-8632 surname: Buness fullname: Buness, Andreas – sequence: 11 givenname: Kerstin U. orcidid: 0000-0002-8541-2519 surname: Ludwig fullname: Ludwig, Kerstin U. – sequence: 12 givenname: Martina U. orcidid: 0000-0002-3778-510X surname: Muckenthaler fullname: Muckenthaler, Martina U. – sequence: 13 givenname: Andrea U. orcidid: 0000-0002-5237-961X surname: Steinbicker fullname: Steinbicker, Andrea U.
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/34946818$$D View this record in MEDLINE/PubMed
BookMark	eNqN0k9rFDEUAPAgFVtrj14l4MXLaP68mWQuQtnaurDoQQVvIZN5U1Nmk5rMLOzND-En7Ccx29bSFgSTQwL55fHeS56TvRADEvKSs7dStuzdOQbMXJSpm_YJORBMyQpA1Hv39vvkKOcLVgYwwVj9jOxLaKHRXB-Q78sUAz3BwTuPwW3pws4Ze9pt6TJMmCcf7Eiv0SrmfPXr96e4wbGw0PveTkjPdjnQISb6BTeYkB4HXHv7gjwd7Jjx6HY9JN9OP3xdfKxWn8-Wi-NV5QD0VLVDC12vWxis6hsuXe9UI2TNoLeu5j122rkBBaACV6Plg1YcdScFh7p2IA_J-5u4l3O3xt5hmJIdzWXya5u2JlpvHp4E_8Ocx43RijHVNiXAm9sAKf6cS8Vm7bPDcbQB45yNaEBr2UgJ_0E5CCmglYW-fkQv4pxKL6-VUAoaVRf16n7yd1n_fZ8CqhvgUul-wuGOcGZ2X8A8-ALFy0fe-clOPu5q9-M_bv0BfCq1sQ
CitedBy_id	crossref_primary_10_1038_s41420_024_02022_2 crossref_primary_10_1016_j_jbc_2025_110705 crossref_primary_10_1080_10408398_2022_2074961
Cites_doi	10.1172/JCI104310 10.1093/nar/gky461 10.1172/JCI104982 10.1007/978-90-481-9485-8_22 10.1172/JCI40372 10.1152/physiolgenomics.00130.2014 10.1016/j.bcmd.2011.07.004 10.1186/s13059-014-0569-x 10.1016/S1097-2765(00)80425-6 10.1186/s12935-015-0242-9 10.1073/pnas.0801318105 10.1182/asheducation-2008.1.151 10.1007/s12185-008-0120-5 10.1038/cr.2015.81 10.1371/journal.pone.0167212 10.1016/j.gene.2015.02.050 10.1097/00003072-197804000-00014 10.1093/jn/130.1.45 10.1126/science.1176639 10.1371/journal.pone.0039902 10.1053/j.seminhematol.2009.06.005 10.1016/0002-9343(68)90069-7 10.1016/j.joca.2014.01.010 10.1182/blood-2010-11-319483 10.1152/ajprenal.00425.2018 10.1038/gim.2016.197 10.1210/jc.2003-031286 10.1093/hmg/8.5.743 10.1073/pnas.151179498 10.1158/0008-5472.CAN-14-2443 10.1016/j.bbamcr.2012.01.014 10.1006/geno.1997.4658 10.1021/bi051559k 10.1371/journal.pone.0205422 10.1016/j.exphem.2006.02.004 10.1038/s41598-018-22096-0 10.1101/gad.1779509 10.1038/nm.3814 10.1182/blood-2012-02-411470 10.3390/nu5083034 10.1055/s-2001-11838 10.1158/1078-0432.1119.11.3 10.1002/pbc.22244 10.1182/blood-2013-06-508325 10.1182/blood-2007-02-072520 10.1182/blood-2011-04-348698 10.1083/jcb.200811072 10.1371/journal.pone.0061202 10.3390/genes11050539 10.1093/hmg/ddx060 10.1113/jphysiol.1938.sp003669 10.1016/j.cmet.2008.09.012 10.1007/BF03032686 10.1097/MOP.0b013e3283425591 10.1172/jci.insight.132964 10.1182/blood.V5.11.983.983 10.1007/s00775-018-1538-8 10.1371/journal.pone.0038136
ContentType	Journal Article
Copyright	2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 by the authors. 2021
Copyright_xml	– notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 by the authors. 2021
DBID	AAYXX CITATION CGR CUY CVF ECM EIF NPM 8FD 8FE 8FH ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 GNUQQ HCIFZ LK8 M7P P64 PHGZM PHGZT PIMPY PKEHL PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 7S9 L.6 5PM
DOI	10.3390/genes12121869
DatabaseName	CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Database ProQuest Central (NC Live) Natural Science Collection ProQuest One Community College ProQuest Central Engineering Research Database ProQuest Central Student SciTech Premium Collection Biological Sciences Biological Science Database Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles)
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences Genetics Abstracts Natural Science Collection ProQuest Central Korea Biological Science Collection ProQuest Central (New) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Biological Science Database ProQuest SciTech Collection Biotechnology and BioEngineering Abstracts ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	AGRICOLA MEDLINE - Academic CrossRef MEDLINE Publicly Available Content Database
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
EISSN	2073-4425
ExternalDocumentID	PMC8700796 34946818 10_3390_genes12121869
Genre	Research Support, Non-U.S. Gov't Journal Article
GeographicLocations	Germany
GeographicLocations_xml	– name: Germany
GroupedDBID	--- 53G 5VS 8FE 8FH AADQD AAFWJ AAHBH AAYXX ADBBV AENEX AFFHD AFKRA AFZYC ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BBNVY BCNDV BENPR BHPHI CCPQU CITATION DIK EBD HCIFZ HYE IAO IHR ITC KQ8 LK8 M48 M7P MODMG M~E OK1 PGMZT PHGZM PHGZT PIMPY PQGLB PROAC RPM CGR CUY CVF ECM EIF GROUPED_DOAJ NPM 8FD ABUWG AZQEC DWQXO FR3 GNUQQ P64 PKEHL PQEST PQQKQ PQUKI PRINS RC3 7X8 PUEGO 7S9 L.6 5PM
ID	FETCH-LOGICAL-c448t-9f94bd894fa7d613cdc7623504dac51deb8ccfe24e74c5ea1f871e8b321455c43
IEDL.DBID	PIMPY
ISICitedReferencesCount	3
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000744736000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	2073-4425
IngestDate	Tue Nov 04 01:55:09 EST 2025 Thu Oct 02 10:56:26 EDT 2025 Thu Oct 02 12:12:08 EDT 2025 Fri Jul 25 12:01:12 EDT 2025 Thu Jan 02 22:54:36 EST 2025 Tue Nov 18 22:29:21 EST 2025 Sat Nov 29 07:13:42 EST 2025
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	12
Keywords	genetically caused iron imbalance iron erythropoiesis intestinal iron loss red cells
Language	English
License	Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c448t-9f94bd894fa7d613cdc7623504dac51deb8ccfe24e74c5ea1f871e8b321455c43
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Former affiliation: Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Muenster, 48149 Muenster, Germany. Current affiliation: German Oncology Center, 4108 Limassol, Cyprus.
ORCID	0000-0002-3778-510X 0000-0002-8541-2519 0000-0002-5237-961X 0000-0003-1889-8632
OpenAccessLink	https://www.proquest.com/publiccontent/docview/2612774675?pq-origsite=%requestingapplication%
PMID	34946818
PQID	2612774675
PQPubID	2032392
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_8700796 proquest_miscellaneous_2648836334 proquest_miscellaneous_2614232493 proquest_journals_2612774675 pubmed_primary_34946818 crossref_primary_10_3390_genes12121869 crossref_citationtrail_10_3390_genes12121869
PublicationCentury	2000
PublicationDate	20211124
PublicationDateYYYYMMDD	2021-11-24
PublicationDate_xml	– month: 11 year: 2021 text: 20211124 day: 24
PublicationDecade	2020
PublicationPlace	Switzerland
PublicationPlace_xml	– name: Switzerland – name: Basel
PublicationTitle	Genes
PublicationTitleAlternate	Genes (Basel)
PublicationYear	2021
Publisher	MDPI AG MDPI
Publisher_xml	– name: MDPI AG – name: MDPI
References	Pixberg (ref_9) 1975; 26 Troadec (ref_38) 2011; 117 Bergmann (ref_40) 2010; 54 ref_14 ref_13 Latour (ref_5) 2012; 120 Yoshida (ref_29) 2015; 75 Ye (ref_39) 2010; 120 Sendamarai (ref_36) 2008; 105 Ricketts (ref_11) 1978; 3 Island (ref_35) 2011; 47 ref_17 ref_16 Pesesse (ref_18) 2014; 22 Kassebaum (ref_1) 2014; 123 Huang (ref_15) 2015; 15 Chen (ref_61) 2009; 23 Iolascon (ref_34) 2009; 46 Meynard (ref_45) 2011; 118 ref_60 Green (ref_49) 1968; 45 ref_20 Savary (ref_42) 1997; 41 Steinbicker (ref_2) 2013; 5 Allikmets (ref_41) 1999; 8 Zhang (ref_37) 2006; 34 Finch (ref_52) 1950; 5 Sankaran (ref_62) 2015; 21 Ganz (ref_32) 2012; 1823 McCance (ref_51) 1938; 94 Vecchi (ref_8) 2009; 325 Barbashina (ref_28) 2005; 11 Rouzier (ref_59) 2017; 26 Muramatsu (ref_63) 2017; 19 Liu (ref_23) 2018; 46 Rennings (ref_58) 2019; 316 ref_30 Pollycove (ref_10) 1961; 40 Zhang (ref_22) 2004; 89 Nicolas (ref_33) 2001; 98 Camaschella (ref_44) 2011; 23 Silvestri (ref_46) 2008; 8 Kohgo (ref_53) 2008; 88 Kreuzer (ref_50) 1991; 29 Closuit (ref_57) 1953; 61 Karmi (ref_19) 2018; 23 Jia (ref_26) 2015; 25 Fomon (ref_48) 2000; 130 Birtel (ref_31) 2018; 8 ref_47 Conrad (ref_54) 1964; 43 Camaschella (ref_43) 2007; 110 Kumar (ref_21) 2015; 561 Benton (ref_25) 2015; 16 McKie (ref_55) 2000; 5 Hurt (ref_24) 2009; 185 Gulbis (ref_3) 2010; 686 Griffiths (ref_56) 2005; 44 Tapernon (ref_12) 2000; 36 ref_4 Holmgren (ref_27) 2015; 47 ref_7 ref_6
References_xml	– volume: 40 start-page: 753 year: 1961 ident: ref_10 article-title: The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects publication-title: J. Clin. Investig. doi: 10.1172/JCI104310 – volume: 46 start-page: 6608 year: 2018 ident: ref_23 article-title: PHD finger protein 1 (PHF1) is a novel reader for histone H4R3 symmetric dimethylation and coordinates with PRMT5-WDR77/CRL4B complex to promote tumorigenesis publication-title: Nucleic Acids Res. doi: 10.1093/nar/gky461 – volume: 43 start-page: 963 year: 1964 ident: ref_54 article-title: The role of the intestine in iron kinetics publication-title: J. Clin. Investig. doi: 10.1172/JCI104982 – volume: 686 start-page: 375 year: 2010 ident: ref_3 article-title: Epidemiology of rare anaemias in Europe publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-90-481-9485-8_22 – volume: 120 start-page: 1749 year: 2010 ident: ref_39 article-title: Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts publication-title: J. Clin. Investig. doi: 10.1172/JCI40372 – volume: 47 start-page: 232 year: 2015 ident: ref_27 article-title: Identification of stable reference genes in differentiating human pluripotent stem cells publication-title: Physiol. Genom. doi: 10.1152/physiolgenomics.00130.2014 – volume: 47 start-page: 243 year: 2011 ident: ref_35 article-title: A novel N491S mutation in the human SLC11A2 gene impairs protein trafficking and in association with the G212V mutation leads to microcytic anemia and liver iron overload publication-title: Blood Cells Mol. Dis. doi: 10.1016/j.bcmd.2011.07.004 – volume: 16 start-page: 8 year: 2015 ident: ref_25 article-title: An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss publication-title: Genome Biol. doi: 10.1186/s13059-014-0569-x – volume: 5 start-page: 299 year: 2000 ident: ref_55 article-title: A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation publication-title: Mol. Cell doi: 10.1016/S1097-2765(00)80425-6 – volume: 15 start-page: 93 year: 2015 ident: ref_15 article-title: Analysis of the expression of PHTF1 and related genes in acute lymphoblastic leukemia publication-title: Cancer Cell Int. doi: 10.1186/s12935-015-0242-9 – volume: 105 start-page: 7410 year: 2008 ident: ref_36 article-title: Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.0801318105 – ident: ref_6 doi: 10.1182/asheducation-2008.1.151 – volume: 61 start-page: 306 year: 1953 ident: ref_57 article-title: Contribution à l’étude du métabolisme du fer à l’aide du radiofer 59/26 Fe. I. Quelques données nouvelles sur l’élimination rénale du fer publication-title: Arch. Int. Physiol. – volume: 88 start-page: 7 year: 2008 ident: ref_53 article-title: Body iron metabolism and pathophysiology of iron overload publication-title: Int. J. Hematol. doi: 10.1007/s12185-008-0120-5 – volume: 25 start-page: 946 year: 2015 ident: ref_26 article-title: Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction publication-title: Cell Res. doi: 10.1038/cr.2015.81 – ident: ref_14 doi: 10.1371/journal.pone.0167212 – ident: ref_4 – volume: 561 start-page: 235 year: 2015 ident: ref_21 article-title: Identification and characterization of methylation-dependent/independent DNA regulatory elements in the human SLC9B1 gene publication-title: Gene doi: 10.1016/j.gene.2015.02.050 – volume: 3 start-page: 159 year: 1978 ident: ref_11 article-title: Ferrokinetics: Methods and interpretation publication-title: Clin. Nucl. Med. doi: 10.1097/00003072-197804000-00014 – volume: 130 start-page: 45 year: 2000 ident: ref_48 article-title: Less than 80% of absorbed iron is promptly incorporated into erythrocytes of infants publication-title: J. Nutr. doi: 10.1093/jn/130.1.45 – volume: 325 start-page: 877 year: 2009 ident: ref_8 article-title: ER stress controls iron metabolism through induction of hepcidin publication-title: Science doi: 10.1126/science.1176639 – ident: ref_30 doi: 10.1371/journal.pone.0039902 – volume: 46 start-page: 358 year: 2009 ident: ref_34 article-title: Mutations in the gene encoding DMT1: Clinical presentation and treatment publication-title: Semin. Hematol. doi: 10.1053/j.seminhematol.2009.06.005 – volume: 45 start-page: 336 year: 1968 ident: ref_49 article-title: Body iron excretion in man: A collaborative study publication-title: Am. J. Med. doi: 10.1016/0002-9343(68)90069-7 – volume: 26 start-page: 1349 year: 1975 ident: ref_9 article-title: Isotopenmethoden in der Anämiediagnostik publication-title: Med. Welt – volume: 22 start-page: 547 year: 2014 ident: ref_18 article-title: Bone sialoprotein as a potential key factor implicated in the pathophysiology of osteoarthritis publication-title: Osteoarthr. Cartil. doi: 10.1016/j.joca.2014.01.010 – volume: 117 start-page: 5494 year: 2011 ident: ref_38 article-title: Targeted deletion of the mouse Mitoferrin1 gene: From anemia to protoporphyria publication-title: Blood doi: 10.1182/blood-2010-11-319483 – volume: 316 start-page: F606 year: 2019 ident: ref_58 article-title: Iron handling by the human kidney: Glomerular filtration and tubular reabsorption both contribute to urinary iron excretion publication-title: Am. J. Physiol. Ren. Physiol. doi: 10.1152/ajprenal.00425.2018 – volume: 19 start-page: 796 year: 2017 ident: ref_63 article-title: Clinical utility of next-generation sequencing for inherited bone marrow failure syndromes publication-title: Genet. Med. doi: 10.1038/gim.2016.197 – volume: 89 start-page: 748 year: 2004 ident: ref_22 article-title: Common variants in glutamine: Fructose-6-phosphate amidotransferase 2 (GFPT2) gene are associated with type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jc.2003-031286 – volume: 8 start-page: 743 year: 1999 ident: ref_41 article-title: Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A) publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/8.5.743 – ident: ref_13 – volume: 98 start-page: 8780 year: 2001 ident: ref_33 article-title: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.151179498 – ident: ref_20 – volume: 75 start-page: 1516 year: 2015 ident: ref_29 article-title: CLK2 Is an Oncogenic Kinase and Splicing Regulator in Breast Cancer publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-14-2443 – volume: 1823 start-page: 1434 year: 2012 ident: ref_32 article-title: Hepcidin and iron homeostasis publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2012.01.014 – volume: 41 start-page: 275 year: 1997 ident: ref_42 article-title: Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human publication-title: Genomics doi: 10.1006/geno.1997.4658 – volume: 44 start-page: 14725 year: 2005 ident: ref_56 article-title: Recombinant expression and functional characterization of human hephaestin: A multicopper oxidase with ferroxidase activity publication-title: Biochemistry doi: 10.1021/bi051559k – ident: ref_16 doi: 10.1371/journal.pone.0205422 – volume: 34 start-page: 593 year: 2006 ident: ref_37 article-title: The anemia of “haemoglobin-deficit” (hbd/hbd) mice is caused by a defect in transferrin cycling publication-title: Exp. Hematol. doi: 10.1016/j.exphem.2006.02.004 – volume: 8 start-page: 4824 year: 2018 ident: ref_31 article-title: Clinical and genetic characteristics of 251 consecutive patients with macular and cone/cone-rod dystrophy publication-title: Sci. Rep. doi: 10.1038/s41598-018-22096-0 – volume: 23 start-page: 1183 year: 2009 ident: ref_61 article-title: Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice publication-title: Genes Dev. doi: 10.1101/gad.1779509 – volume: 21 start-page: 221 year: 2015 ident: ref_62 article-title: Anemia: Progress in molecular mechanisms and therapies publication-title: Nat. Med. doi: 10.1038/nm.3814 – volume: 120 start-page: 431 year: 2012 ident: ref_5 article-title: Induction of activin B by inflammatory stimuli up-regulates expression of the iron-regulatory peptide hepcidin through Smad1/5/8 signaling publication-title: Blood doi: 10.1182/blood-2012-02-411470 – volume: 5 start-page: 3034 year: 2013 ident: ref_2 article-title: Out of balance—Systemic iron homeostasis in iron-related disorders publication-title: Nutrients doi: 10.3390/nu5083034 – volume: 36 start-page: 45 year: 2000 ident: ref_12 article-title: Qualitätskontrolle der Hämolyserate von Erythrozytenkonzentraten: Ringversuch zur Bestimmung von freiem Hämoglobin [Quality control of hemolysis rate of erythrocyte concentrates: A proficiency test for determination of free hemoglobin] publication-title: Anasthesiol. Intensivmed. Notfallmed. Schmerzther doi: 10.1055/s-2001-11838 – volume: 11 start-page: 1119 year: 2005 ident: ref_28 article-title: Allelic losses at 1p36 and 19q13 in gliomas: Correlation with histologic classification, definition of a 150-kb minimal deleted region on 1p36, and evaluation of CAMTA1 as a candidate tumor suppressor gene publication-title: Clin. Cancer Res. Off. J. Am. Assoc. Cancer Res. doi: 10.1158/1078-0432.1119.11.3 – volume: 54 start-page: 273 year: 2010 ident: ref_40 article-title: Systematic molecular genetic analysis of congenital sideroblastic anemia: Evidence for genetic heterogeneity and identification of novel mutations publication-title: Pediatric Blood Cancer doi: 10.1002/pbc.22244 – volume: 123 start-page: 615 year: 2014 ident: ref_1 article-title: A systematic analysis of global anemia burden from 1990 to 2010 publication-title: Blood doi: 10.1182/blood-2013-06-508325 – volume: 110 start-page: 1353 year: 2007 ident: ref_43 article-title: The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload publication-title: Blood doi: 10.1182/blood-2007-02-072520 – volume: 118 start-page: 747 year: 2011 ident: ref_45 article-title: Regulation of TMPRSS6 by BMP6 and iron in human cells and mice publication-title: Blood doi: 10.1182/blood-2011-04-348698 – volume: 185 start-page: 265 year: 2009 ident: ref_24 article-title: A conserved CCCH-type zinc finger protein regulates mRNA nuclear adenylation and export publication-title: J. Cell Biol. doi: 10.1083/jcb.200811072 – ident: ref_60 doi: 10.1371/journal.pone.0061202 – ident: ref_17 doi: 10.3390/genes11050539 – volume: 26 start-page: 1599 year: 2017 ident: ref_59 article-title: A novel CISD2 mutation associated with a classical Wolfram syndrome phenotype alters Ca2+ homeostasis and ER-mitochondria interactions publication-title: Hum. Mol. Genet. doi: 10.1093/hmg/ddx060 – volume: 94 start-page: 148 year: 1938 ident: ref_51 article-title: The absorption and excretion of iron following oral and intravenous administration publication-title: J. Physiol. doi: 10.1113/jphysiol.1938.sp003669 – volume: 8 start-page: 502 year: 2008 ident: ref_46 article-title: The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin publication-title: Cell Metab. doi: 10.1016/j.cmet.2008.09.012 – volume: 29 start-page: 77 year: 1991 ident: ref_50 article-title: Endogenous iron excretion. A quantitative means to control iron metabolism? publication-title: Biol. Trace Elem. Res. doi: 10.1007/BF03032686 – volume: 23 start-page: 14 year: 2011 ident: ref_44 article-title: Inherited disorders of iron metabolism publication-title: Curr. Opin. Pediatr. doi: 10.1097/MOP.0b013e3283425591 – ident: ref_47 doi: 10.1172/jci.insight.132964 – volume: 5 start-page: 983 year: 1950 ident: ref_52 article-title: Iron metabolism: The pathophysiology of iron storage publication-title: Blood doi: 10.1182/blood.V5.11.983.983 – volume: 23 start-page: 599 year: 2018 ident: ref_19 article-title: The unique fold and lability of the 2Fe-2S clusters of NEET proteins mediate their key functions in health and disease publication-title: J. Biol. Inorg. Chem. JBIC A Publ. Soc. Biol. Inorg. Chem. doi: 10.1007/s00775-018-1538-8 – ident: ref_7 doi: 10.1371/journal.pone.0038136
SSID	ssj0000402005
Score	2.2409234
Snippet	The adult human body contains about 4 g of iron. About 1–2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We... The adult human body contains about 4 g of iron. About 1-2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We...
SourceID	pubmedcentral proquest pubmed crossref
SourceType	Open Access Repository Aggregation Database Index Database Enrichment Source
StartPage	1869
SubjectTerms	Aged Aged, 80 and over Anemia Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - etiology Anemia, Iron-Deficiency - genetics Biopsy Bleeding Blood Bone marrow Chronic illnesses Cytokines diagnostic techniques Erythrocytes Erythropoiesis Erythropoiesis - genetics Excretion Families & family life Feces Female Ferritin Gastrointestinal Tract - metabolism Genetic diversity Genetic Variation - genetics Graphite Hemoglobin Hemorrhage - complications Hemorrhage - genetics Heredity Humans Intestine intestines Intravenous administration intravenous injection Iron Iron - blood Iron - metabolism Iron - urine Iron Deficiencies - etiology Iron Deficiencies - genetics Iron deficiency iron deficiency anemia liver Magnetic resonance imaging Male Middle Aged Mutation Mutation - genetics Nutrient deficiency Patients Plasma probability urine
Title	Iron Deficiency Caused by Intestinal Iron Loss—Novel Candidate Genes for Severe Anemia
URI	https://www.ncbi.nlm.nih.gov/pubmed/34946818 https://www.proquest.com/docview/2612774675 https://www.proquest.com/docview/2614232493 https://www.proquest.com/docview/2648836334 https://pubmed.ncbi.nlm.nih.gov/PMC8700796
Volume	12
WOSCitedRecordID	wos000744736000001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2073-4425 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402005 issn: 2073-4425 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2073-4425 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402005 issn: 2073-4425 databaseCode: M7P dateStart: 20100301 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2073-4425 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402005 issn: 2073-4425 databaseCode: BENPR dateStart: 20100301 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2073-4425 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000402005 issn: 2073-4425 databaseCode: PIMPY dateStart: 20100301 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEB7RBCQu5VkwlGiRECes2N7161SVNhWVILJ4SOFk2eNZiFTsNk4q9YL4EfzC_hJ2bMclIHri4suOpV3Nzrczs7PfALxAQu2S0UCg_cBWqD07K9CzVeyS1H6oI5U1zSbC6TSazeKkex5dd2WVa0xsgLple-a6bQPC46JCzpiPmfgq5E4Z_t7pmc09pPiutWuosQVDJt5yBjBMjt8ln_uci8PBkuO3VJvSRPvjLwworoFv7sy0eTT95W_-WTb52zl0dOf_ruAubHf-qNhvN9A9uEHlfbjVdqi8eACz40VVikNingl-pCkOslVNhcgvBOcSDT7w343QW7Omyx8_p9U5nRixsphzMkEwr3UtjGssPpAxGxL7JX2bZw_h09Hk48Ebu2vGYKOJ4JZ2rGOVF1GsdBYWxgfAAg2OSt9RRYa-W1AeIWryFIUKfcpcbUIxinLZUKGjkjswKKuSHoPgmz4T12BAea48z8089DFQudLka4lowau1HlLsmMq5YcZJaiIWVlu6oTYLXvbipy1Fx78Ed9eKSTtLrdMrPVjwvB82NsYXJ1lJ1aqR4ftsFcvrZAwUykBKZcGjdp_0s2EKoMB4RhaEGzuoF2CO782Rcv614fo2cOqEcfDk-qk_hdse19q4ru2pXRgsFyt6BjfxfDmvFyPYCmfRCIavJ9Pk_YirWxP-fp-MOgP5BchWIeY
linkProvider	ProQuest
linkToHtml	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3NbtNAEB6VFAQX_imGAosEnLBqe9d_B4SqlqpR0ygSRQonY69naaRilzgpyo2H4Dl4KJ6EGdsxBERvPXDesbX2zH4zs7P7DcAzjdq4SBoIjB_YShvPTnPt2Sp2URo_NJFK62YT4XAYjcfxaA2-L-_C8LHKJSbWQJ2XmvfIt5jqKuTeGP7r0882d43i6uqyhUZjFge4-EIpW_Wqv0v6fe55e2-OdvbttquArSkVmdmxiVWWR7EyaZiTM9O5JkCQvqPyVPtujlmktUFPYai0j6lrKKfAKJM1p7dWkt57CdYVGbvTg_VR_3D0vtvVcTgdc_yGzFPK2Nn6yJDlkoPg3k-rzu-viPbPg5m_ebq9G__bP7oJ19uYWmw3i-AWrGFxG640XTYXd2Dcn5aF2EXmyuCLpmInnVeYi2wheD-UMI6froUG9Nd-fP02LM_whMSKfMIbIoK5uStB4b14i7T0UWwX-GmS3oV3F_JZ96BXlAXeB8HVSsrNdIBZpjzPTT3t60BlyqBvpNYWvFxqOtEt2zo3_ThJKOtiw0hWDMOCF534aUMz8i_BzaXqkxZtquSX3i142g0TTnDxJy2wnNcyXJNXsTxPhuBcBlIqCzYaS-xmwzRGAUV3FoQrNtoJME_56kgxOa75ysklOGEcPDh_6k_g6v7R4SAZ9IcHD-Gax2eHXNf21Cb0ZtM5PoLL-mw2qaaP20Un4MNF2_BPEABwQw
linkToPdf	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lj9MwEB4tXUBceD8KCxgJOBE1sZ3XAaFluxXVrqqKh9RbSJwxVFqSpWkX9caP4Nfwc_glzCRpoSD2tgfOnkRO_Pkbj8f-BuCxQWM9pBEIrB842ljppLmRjo49VNYPbaTTuthEOBpFk0k83oLvq7swfKxyxYk1Ueel4T3yHktdhVwbw-_Z9ljEuD94cfzZ4QpSnGldldNoIHKAyy8UvlXPh30a6ydSDvbf7r1y2goDjqGwZO7ENtZZHsXapmFOjs3khshB-a7OU-N7OWaRMRalxlAbH1PPUnyBUaZqfW-jFb33HGyHioKeDmy_3B-NX693eFwOzVy_EfZUKnZ7H5i-PHIWXAdq0xH-tbr985Dmb15vcOV__l9X4XK71ha7zeS4BltYXIcLTfXN5Q2YDGdlIfrIGhp8AVXspYsKc5EtBe-TEvfx07XRIf3BH1-_jcoTPCKzIp_yRolgze5K0LJfvEGiBBS7BX6apjfh3Zl81i3oFGWBd0BwFpNiNhNglmkpvVQa3wQ60xZ9q4zpwrPVqCemVWHnYiBHCUVjDJJkAyRdeLo2P27kR_5luLOCQdKyUJX8wkAXHq2biT84KZQWWC5qG87V61idZkM0rwKldBduN6hc94bljQJa9XUh3MDr2oD1yzdbiunHWsecXIUbxsHd07v-EC4ScJPD4ejgHlySfKTI8xypd6Azny3wPpw3J_NpNXvQzj8B788awj8BVz543Q
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Iron+Deficiency+Caused+by+Intestinal+Iron+Loss%E2%80%94Novel+Candidate+Genes+for+Severe+Anemia&rft.jtitle=Genes&rft.au=Huettmann%2C+Carolina&rft.au=Stelljes%2C+Matthias&rft.au=Sivalingam%2C+Sugirthan&rft.au=Fobker%2C+Manfred&rft.date=2021-11-24&rft.pub=MDPI+AG&rft.eissn=2073-4425&rft.volume=12&rft.issue=12&rft.spage=1869&rft_id=info:doi/10.3390%2Fgenes12121869&rft.externalDBID=HAS_PDF_LINK
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2073-4425&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2073-4425&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2073-4425&client=summon