Acute leukoencephalopathy associated with daratumumab treatment in POEMS syndrome: a case report

Daratumumab, a monoclonal antibody against CD38, is increasingly used in the treatment of multiple myeloma, other hematological malignancies and autoimmune diseases. Little is known about its CNS toxicity. We present a case of a patient with POEMS syndrome (syndrome of polyneuropathy, organomegaly,...

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Bibliographic Details
Published in:	Frontiers in immunology Vol. 15; p. 1451693
Main Authors:	Steinegger, Lukas, Nierobisch, Nathalie, De Vere-Tyndall, Anthony, Schreiner, Bettina, Roth, Patrick, Kappos, Ludwig, Kana, Veronika, Herwerth, Marina
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media SA 26.09.2024 Frontiers Media S.A
Subjects:	Antibodies Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Ataxia Autoimmune diseases Blood pressure Case reports CD38 antigen CD38-antibody daratumumab Edema Encephalitis Endocrine disorders Female Humans Immunology Immunomodulators Ischemia Laboratories Leukoencephalopathies - chemically induced Leukoencephalopathy Magnetic Resonance Imaging Male Malignancy Middle Aged Monoclonal antibodies Monoclonal gammopathy Multiple myeloma Nervous system Patients POEMS Syndrome - diagnosis POEMS Syndrome - drug therapy Polyneuropathy rapidly progressive leukoencephalopathy Steroids toxic leukoencephalopathy Toxicity Vascular endothelial growth factor Vigilance POEMS CD38-antibody daratumumab toxic leukoencephalopathy rapidly progressive leukoencephalopathy
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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