Mildronate decreases carnitine availability and up-regulates glucose uptake and related gene expression in the mouse heart

l-carnitine has been shown to play a central role in both fat and carbohydrate metabolisms. This study investigated whether acute and long-term treatments with an l-carnitine biosynthesis inhibitor, mildronate (3-(2,2,2-trimethylhydrazinium) propionate), modulate glucose uptake. The effects of acute...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 83; no. 17; pp. 613 - 619
Main Authors:	Liepinsh, Edgars, Vilskersts, Reinis, Skapare, Elina, Svalbe, Baiba, Kuka, Janis, Cirule, Helena, Pugovics, Osvalds, Kalvinsh, Ivars, Dambrova, Maija
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 24.10.2008
Subjects:	Animals Betaine - analogs & derivatives Betaine - analysis C-Peptide - analysis Cardiac energy metabolism Carnitine Carnitine - analysis Carnitine - metabolism Gene Expression Regulation - drug effects Glucose - metabolism Glucose Transporter Type 4 - genetics Glucose uptake Heart - drug effects Hexokinase - genetics Male Methylhydrazines - pharmacology Mice Mice, Inbred ICR Mildronate Myocardium - metabolism RNA, Messenger - analysis Up-Regulation FFA Cardiac energy metabolism HK II GLUT 4 INSR GBB PDC-E2 GLUT 1 PDC-E1 PDC Carnitine CPT IB LDH HDL Glucose uptake CPT IA FA Mildronate
ISSN:	0024-3205, 1879-0631
Online Access:	Get full text
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