Anxiogenic Potential of Experimental Sleep Fragmentation Is Duration-Dependent and Mediated via Oxidative Stress State
Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothes...
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| Vydané v: | Oxidative medicine and cellular longevity Ročník 2021; číslo 1; s. 2262913 |
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| Hlavní autori: | , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Hindawi
2021
John Wiley & Sons, Inc |
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| ISSN: | 1942-0900, 1942-0994, 1942-0994 |
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| Abstract | Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light-dark tests on the 0, 7th, and 14th day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety-linked behavior suggested duration-dependent anxiogenic potential of sleep fragmentation. Rats’ anxiety-linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes’ activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety-linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation-oxidative stress-anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns. |
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| AbstractList | Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light-dark tests on the 0, 7th, and 14th day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety-linked behavior suggested duration-dependent anxiogenic potential of sleep fragmentation. Rats' anxiety-linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes' activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety-linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation-oxidative stress-anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns.Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light-dark tests on the 0, 7th, and 14th day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety-linked behavior suggested duration-dependent anxiogenic potential of sleep fragmentation. Rats' anxiety-linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes' activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety-linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation-oxidative stress-anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns. Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light-dark tests on the 0, 7th, and 14th day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety-linked behavior suggested duration-dependent anxiogenic potential of sleep fragmentation. Rats’ anxiety-linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes’ activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety-linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation-oxidative stress-anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns. Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light‐dark tests on the 0, 7 th , and 14 th day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety‐linked behavior suggested duration‐dependent anxiogenic potential of sleep fragmentation. Rats’ anxiety‐linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes’ activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety‐linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation‐oxidative stress‐anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns. Sleep architecture alterations, among which sleep fragmentation is highly prevalent, represent risk factors for a variety of diseases, ranging from cardiovascular to brain disorders, including anxiety. What mediates anxiety occurrence upon sleep fragmentation is still a matter of debate. We hypothesized that the sleep fragmentation effects on anxiety are dependent on its duration and mediated by increased oxidative stress and alterations in the number of parvalbumin (PV+) interneurons in the hippocampus. Sleep was fragmented in rats by the treadmill method during a period of 14 days (SF group). Rats with undisturbed sleep in the treadmill (TC group) and those receiving equal amounts of treadmill belt motion (EC group) served as controls. To assess anxiety, we subjected rats to the open field, elevated plus maze, and light-dark tests on the 0, 7 , and 14 day. Upon the last test, brain structures were sampled for oxidative stress assessment and PV+ interneuron immunohistochemistry. The results of ethological tests of anxiety-linked behavior suggested duration-dependent anxiogenic potential of sleep fragmentation. Rats' anxiety-linked behavior upon sleep fragmentation significantly correlated with oxidative stress. The rats with fragmented sleep (SF) showed significantly higher oxidative stress in the hippocampus, thalamus, and cortex, compared to controls (TC and EC), while the antioxidant enzymes' activity was significantly decreased. No significant differences were observed in hippocampal PV+ interneurons among these groups. Our results showed that duration of sleep fragmentation is a significant determinant of anxiety-linked behavior, and these effects are mediated through oxidative distress in the brain. Herein, it is revealed that the sleep fragmentation-oxidative stress-anxiety axis contributes to our better understanding of pathophysiological processes, occurring due to disrupted sleep patterns. |
| Author | Puškaš, Nela Simić, Tatjana Stanojlović, Olivera Macut, Djuro Rašić-Marković, Aleksandra Hrnčić, Dragan Grubač, Željko Šutulović, Nikola Jerotić, Djurdja Šuvakov, Sonja |
| AuthorAffiliation | 4 Clinic of Endocrinology, Diabetes and Metabolic Disease, UCCS, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia 2 Institute of Clinical and Medical Biochemistry, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia 1 Institute of Medical Physiology “Richard Burian”, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia 3 Institute of Histology and Embryology “Aleksandar Đ. Kostić”, Belgrade University Faculty of Medicine, 11000 Belgrade, Serbia |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34471462$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1164/ajrccm.165.7.2104126 10.1164/ajrccm.162.2.9908091 10.1016/j.intimp.2021.107436 10.1093/sleep/25.3.268 10.1038/sj.npp.1300581 10.1164/rccm.201107-1173OC 10.1111/j.1471-4159.2006.03907.x 10.1016/j.neuroscience.2007.03.009 10.5665/sleep.4572 10.1371/journal.pone.0218920 10.1016/0009-8981(83)90035-9 10.1016/j.neures.2011.01.008 10.1016/j.biocel.2006.07.001 10.1093/sleep/17.1.84 10.5665/sleep.5154 10.1016/0076-6879(87)43013-9 10.1056/NEJM199304293281704 10.1097/00001756-200208070-00007 10.1111/j.1365-2869.2012.01029.x 10.1016/S0165-1781(98)00068-7 10.2147/NSS.S134864 10.1016/S0021-9258(19)45228-9 10.1016/j.sleep.2020.07.048 10.5665/sleep.3034 10.1155/2021/6687493 10.1053/smrv.1999.0095 10.1515/cclm.1974.12.10.444 10.31887/DCNS.2003.5.3/lstaner 10.1016/j.neuroscience.2004.03.055 10.2174/1570159X11666131120223530 10.1053/smrv.1999.0096 10.3390/ijerph15102066 10.1155/2019/3426092 10.1136/oem.56.5.289 10.1093/cercor/bhw001 10.1007/s12031-014-0403-7 10.1016/j.nbd.2007.07.013 10.1093/sleep/zsy201 10.5664/jcsm.4692 10.1186/1742-2094-9-91 10.1016/j.neuroscience.2004.09.057 10.1371/journal.pone.0181978 10.2174/1570159X11666131120232135 10.1016/j.neuroscience.2016.03.062 10.1523/JNEUROSCI.2592-15.2015 10.1016/j.physbeh.2015.12.016 10.1139/cjpp-2015-0581 10.1016/j.pnpbp.2007.07.017 10.1155/2015/591729 10.1016/0001-4575(96)00021-8 10.1016/j.psychres.2020.113361 10.1016/bs.apcsb.2019.03.001 10.1016/j.neubiorev.2016.06.028 10.1080/10550887.2020.1717281 10.1053/smrv.2001.0245 10.1016/0924-977X(95)00023-I 10.31887/DCNS.2005.7.4/jhabarubio 10.1017/S1461145707008401 10.1007/s10522-008-9124-z 10.1080/09540260500104508 10.1016/j.neures.2010.08.007 10.1378/chest.08-1834 10.1007/s00127-017-1474-x 10.2147/TCRM.S48528 10.1159/000503728 |
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| Copyright | Copyright © 2021 Željko Grubač et al. Copyright © 2021 Željko Grubač et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0 Copyright © 2021 Željko Grubač et al. 2021 |
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| References | e_1_2_12_2_2 e_1_2_12_4_2 e_1_2_12_19_2 e_1_2_12_17_2 e_1_2_12_15_2 e_1_2_12_38_2 e_1_2_12_59_2 e_1_2_12_41_2 e_1_2_12_64_2 e_1_2_12_20_2 e_1_2_12_62_2 e_1_2_12_22_2 Karkoulias K. (e_1_2_12_44_2) 2013; 17 e_1_2_12_45_2 e_1_2_12_68_2 e_1_2_12_24_2 e_1_2_12_47_2 e_1_2_12_66_2 e_1_2_12_60_2 Trammell R. A. (e_1_2_12_43_2) 2014; 64 e_1_2_12_26_2 e_1_2_12_49_2 e_1_2_12_28_2 e_1_2_12_52_2 e_1_2_12_31_2 e_1_2_12_54_2 e_1_2_12_33_2 e_1_2_12_56_2 e_1_2_12_35_2 e_1_2_12_58_2 e_1_2_12_14_2 e_1_2_12_12_2 e_1_2_12_10_2 e_1_2_12_6_2 e_1_2_12_50_2 e_1_2_12_8_2 e_1_2_12_3_2 e_1_2_12_5_2 e_1_2_12_18_2 e_1_2_12_1_2 e_1_2_12_16_2 e_1_2_12_37_2 e_1_2_12_39_2 Bajpai S. (e_1_2_12_46_2) 2014; 26 e_1_2_12_40_2 e_1_2_12_65_2 e_1_2_12_21_2 e_1_2_12_42_2 e_1_2_12_63_2 e_1_2_12_23_2 e_1_2_12_69_2 e_1_2_12_25_2 e_1_2_12_67_2 e_1_2_12_61_2 e_1_2_12_27_2 e_1_2_12_48_2 e_1_2_12_29_2 e_1_2_12_30_2 e_1_2_12_51_2 e_1_2_12_32_2 e_1_2_12_53_2 e_1_2_12_34_2 e_1_2_12_55_2 Tyler D. B. (e_1_2_12_9_2) 1955; 16 e_1_2_12_36_2 e_1_2_12_57_2 e_1_2_12_13_2 e_1_2_12_11_2 e_1_2_12_7_2 |
| References_xml | – ident: e_1_2_12_28_2 doi: 10.1164/ajrccm.165.7.2104126 – ident: e_1_2_12_27_2 doi: 10.1164/ajrccm.162.2.9908091 – ident: e_1_2_12_30_2 doi: 10.1016/j.intimp.2021.107436 – ident: e_1_2_12_4_2 doi: 10.1093/sleep/25.3.268 – volume: 64 start-page: 13 year: 2014 ident: e_1_2_12_43_2 article-title: Effects of sleep fragmentation on sleep and markers of inflammation in mice publication-title: Comparative Medicine – ident: e_1_2_12_68_2 doi: 10.1038/sj.npp.1300581 – ident: e_1_2_12_13_2 doi: 10.1164/rccm.201107-1173OC – ident: e_1_2_12_61_2 doi: 10.1111/j.1471-4159.2006.03907.x – ident: e_1_2_12_3_2 doi: 10.1016/j.neuroscience.2007.03.009 – ident: e_1_2_12_11_2 doi: 10.5665/sleep.4572 – ident: e_1_2_12_25_2 doi: 10.1371/journal.pone.0218920 – ident: e_1_2_12_36_2 doi: 10.1016/0009-8981(83)90035-9 – ident: e_1_2_12_52_2 doi: 10.1016/j.neures.2011.01.008 – ident: e_1_2_12_26_2 doi: 10.1016/j.biocel.2006.07.001 – ident: e_1_2_12_14_2 doi: 10.1093/sleep/17.1.84 – ident: e_1_2_12_5_2 doi: 10.5665/sleep.5154 – ident: e_1_2_12_39_2 doi: 10.1016/0076-6879(87)43013-9 – ident: e_1_2_12_10_2 doi: 10.1056/NEJM199304293281704 – ident: e_1_2_12_29_2 doi: 10.1097/00001756-200208070-00007 – ident: e_1_2_12_24_2 doi: 10.1111/j.1365-2869.2012.01029.x – ident: e_1_2_12_20_2 doi: 10.1016/S0165-1781(98)00068-7 – ident: e_1_2_12_1_2 doi: 10.2147/NSS.S134864 – ident: e_1_2_12_37_2 doi: 10.1016/S0021-9258(19)45228-9 – ident: e_1_2_12_59_2 doi: 10.1016/j.sleep.2020.07.048 – ident: e_1_2_12_23_2 doi: 10.5665/sleep.3034 – volume: 16 start-page: 293 year: 1955 ident: e_1_2_12_9_2 article-title: Psychological changes during experimental sleep deprivation publication-title: Diseases of the Nervous System – ident: e_1_2_12_67_2 doi: 10.1155/2021/6687493 – ident: e_1_2_12_21_2 doi: 10.1053/smrv.1999.0095 – ident: e_1_2_12_38_2 doi: 10.1515/cclm.1974.12.10.444 – ident: e_1_2_12_18_2 doi: 10.31887/DCNS.2003.5.3/lstaner – volume: 17 start-page: 531 year: 2013 ident: e_1_2_12_44_2 article-title: The impact of obstructive sleep apnea syndrome severity on physical performance and mental health. The use of SF-36 questionnaire in sleep apnea publication-title: European Review for Medical and Pharmacological Sciences – ident: e_1_2_12_60_2 doi: 10.1016/j.neuroscience.2004.03.055 – ident: e_1_2_12_35_2 doi: 10.2174/1570159X11666131120223530 – ident: e_1_2_12_19_2 doi: 10.1053/smrv.1999.0096 – volume: 26 start-page: 163 year: 2014 ident: e_1_2_12_46_2 article-title: Obstructive sleep apnea and risk for late-life depression publication-title: Ann. Clin. Psychiatry Off. J. Am. Acad. Clin. Psychiatr. – ident: e_1_2_12_57_2 doi: 10.3390/ijerph15102066 – ident: e_1_2_12_69_2 doi: 10.1155/2019/3426092 – ident: e_1_2_12_16_2 doi: 10.1136/oem.56.5.289 – ident: e_1_2_12_65_2 doi: 10.1093/cercor/bhw001 – ident: e_1_2_12_42_2 doi: 10.1007/s12031-014-0403-7 – ident: e_1_2_12_56_2 doi: 10.1016/j.nbd.2007.07.013 – ident: e_1_2_12_64_2 doi: 10.1093/sleep/zsy201 – ident: e_1_2_12_17_2 doi: 10.5664/jcsm.4692 – ident: e_1_2_12_22_2 doi: 10.1186/1742-2094-9-91 – ident: e_1_2_12_50_2 doi: 10.1016/j.neuroscience.2004.09.057 – ident: e_1_2_12_58_2 doi: 10.1371/journal.pone.0181978 – ident: e_1_2_12_34_2 doi: 10.2174/1570159X11666131120232135 – ident: e_1_2_12_40_2 doi: 10.1016/j.neuroscience.2016.03.062 – ident: e_1_2_12_7_2 doi: 10.1523/JNEUROSCI.2592-15.2015 – ident: e_1_2_12_54_2 doi: 10.1016/j.physbeh.2015.12.016 – ident: e_1_2_12_32_2 doi: 10.1139/cjpp-2015-0581 – ident: e_1_2_12_12_2 doi: 10.1016/j.pnpbp.2007.07.017 – ident: e_1_2_12_6_2 doi: 10.1155/2015/591729 – ident: e_1_2_12_15_2 doi: 10.1016/0001-4575(96)00021-8 – ident: e_1_2_12_55_2 doi: 10.1016/j.psychres.2020.113361 – ident: e_1_2_12_63_2 doi: 10.1016/bs.apcsb.2019.03.001 – ident: e_1_2_12_41_2 doi: 10.1016/j.neubiorev.2016.06.028 – ident: e_1_2_12_53_2 doi: 10.1080/10550887.2020.1717281 – ident: e_1_2_12_2_2 doi: 10.1053/smrv.2001.0245 – ident: e_1_2_12_8_2 doi: 10.1016/0924-977X(95)00023-I – ident: e_1_2_12_49_2 doi: 10.31887/DCNS.2005.7.4/jhabarubio – ident: e_1_2_12_62_2 doi: 10.1017/S1461145707008401 – ident: e_1_2_12_51_2 doi: 10.1007/s10522-008-9124-z – ident: e_1_2_12_47_2 doi: 10.1080/09540260500104508 – ident: e_1_2_12_33_2 doi: 10.1016/j.neures.2010.08.007 – ident: e_1_2_12_48_2 doi: 10.1378/chest.08-1834 – ident: e_1_2_12_45_2 doi: 10.1007/s00127-017-1474-x – ident: e_1_2_12_66_2 doi: 10.2147/TCRM.S48528 – ident: e_1_2_12_31_2 doi: 10.1159/000503728 |
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| SubjectTerms | Animal cognition Animals Anxiety - physiopathology Anxiety disorders Fitness equipment Humans Hypoxia Laboratory animals Male Medical research Oxidative stress Oxidative Stress - physiology Rats Rats, Wistar Sleep apnea Sleep Deprivation - physiopathology |
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| Title | Anxiogenic Potential of Experimental Sleep Fragmentation Is Duration-Dependent and Mediated via Oxidative Stress State |
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