High intratumoral CD8+ T‐cell infiltration is associated with improved survival in prostate cancer patients undergoing radical prostatectomy

Background A high density of CD8+ tumor infiltrating lymphocytes (TILs) is associated with improved survival in multiple cancers, but its prognostic role in prostate cancer remains controversial. The aim of our study was to evaluate the prognostic value of CD8+ TILs in prostate cancer patients under...

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Bibliographic Details
Published in:	The Prostate Vol. 81; no. 1; pp. 20 - 28
Main Authors:	Yang, Yuanquan, Attwood, Kristopher, Bshara, Wiam, Mohler, James L., Guru, Khurshid, Xu, Bo, Kalinski, Pawel, Chatta, Gurkamal
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.01.2021
Subjects:	Adult Aged Cancer surgery CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - pathology Cell density Clinical outcomes Cohort Studies Cytotoxicity Humans Immunohistochemistry Immunomodulation Immunotherapy Infiltration Lymphocytes Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - pathology Male Metastases Middle Aged Multivariate Analysis Neoplasm Staging Patients Prognosis Prostate cancer Prostatectomy Prostatic Neoplasms - immunology Prostatic Neoplasms - mortality Prostatic Neoplasms - surgery radical prostatectomy Retrospective Studies Survival Rate tumor infiltrating lymphocyte tumor tissue microarray Urological surgery prostate cancer tumor tissue microarray radical prostatectomy immunohistochemistry tumor infiltrating lymphocyte
ISSN:	0270-4137, 1097-0045, 1097-0045
Online Access:	Get full text
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