ATF6α promotes prostate cancer progression by enhancing PLA2G4A‐mediated arachidonic acid metabolism and protecting tumor cells against ferroptosis

Background Despite the clinical success of androgen receptor (AR)‐targeted therapies, prostate cancer (PCa) inevitably progresses to castration‐resistant prostate cancer (CRPC). Transcription factor 6 α (ATF6α), an effector of the unfolded protein response (UPR) that modulates the cellular response...

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Vydáno v:	The Prostate Ročník 82; číslo 5; s. 617 - 629
Hlavní autoři:	Zhao, Ru, Lv, Ye, Feng, Tingting, Zhang, Ruojia, Ge, Luna, Pan, Jihong, Han, Bo, Song, Guanhua, Wang, Lin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Wiley Subscription Services, Inc 01.04.2022 John Wiley and Sons Inc
Témata:	Androgen Antagonists - therapeutic use Androgen receptors Androgens Arachidonic acid Arachidonic Acid - therapeutic use ATF6α Castration Cell death Cell Line, Tumor Chromatin CRPC Dinoprostone Endoplasmic reticulum Ferroptosis Group IV Phospholipases A2 Humans Immunoprecipitation Male Metastases Neoplasm Recurrence, Local Original PGE2 Phenotypes PLA2G4A Polymerase chain reaction Prostaglandin E2 Prostate cancer Prostatic Neoplasms, Castration-Resistant - drug therapy Protein folding Receptors, Androgen - metabolism Tumor cells AA PGE2 PLA2G4A ferroptosis ATF6α CRPC
ISSN:	0270-4137, 1097-0045, 1097-0045
On-line přístup:	Získat plný text
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