Strain-compounding technique with ultrasound Nakagami imaging for distinguishing between benign and malignant breast tumors

Purpose : The scatterer properties of breast tissues are related to the presence of collagen structures, while the elasticity properties of breast tissues depend on their structural organization; these two characteristics are functionally complementary in ultrasound-based tissue characterizations. T...

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Vydáno v:	Medical physics (Lancaster) Ročník 39; číslo 5; s. 2325 - 2333
Hlavní autoři:	Liao, Yin-Yin, Li, Chia-Hui, Tsui, Po-Hsiang, Chang, Chien-Cheng, Kuo, Wen-Hung, Chang, King-Jen, Yeh, Chih-Kuang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States American Association of Physicists in Medicine 01.05.2012
Témata:	Adult Backscattering biological organs Biomechanics Biomedical imaging biomedical ultrasonics Breast - pathology Breast Neoplasms - diagnostic imaging Breast Neoplasms - pathology breast ultrasound Cancer Computer aided diagnosis data compression Diagnosis using ultrasonic, sonic or infrasonic waves Diagnosis, Differential Digital computing or data processing equipment or methods, specially adapted for specific applications Elastic properties elasticity Elasticity Imaging Techniques - methods Female gynaecology Humans image coding Image coding, e.g. from bit‐mapped to non bit‐mapped Image data processing or generation, in general medical image processing Medical imaging Middle Aged proteins ROC Curve scatterer characteristics Scattering, Radiation sensitivity analysis Speckle Statistical properties strain-compounding Nakagami image Structure tumours Ultrasonic scattering Ultrasonography X‐ray scattering scatterer characteristics breast ultrasound strain-compounding Nakagami image elastic properties
ISSN:	0094-2405, 2473-4209
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Shrnutí:	Purpose : The scatterer properties of breast tissues are related to the presence of collagen structures, while the elasticity properties of breast tissues depend on their structural organization; these two characteristics are functionally complementary in ultrasound-based tissue characterizations. This study investigated the use of a strain-compounding technique with Nakagami imaging to provide information associated with the scatterer and elasticity characteristics of tissues when attempting to identify benign and malignant breast tumors. Methods : The efficacy of the proposed method was tested by collecting raw data of ultrasound backscattered signals from 50 clinical cases (25 benign tumors and 25 malignant tumors, as verified by histology biopsies). The different strain conditions were created by applying manual compression. For each region in which breast tumors were suspected, estimates of the full width at half maximum (FWHM) from the Gaussian fitting curve for the Nakagami-parameter histogram in the strain-compounding Nakagami images were divided by those of the corresponding reference Nakagami images (uncompressed images); this parameter was denoted as the FWHM ratio. Receiver operating characteristic (ROC) curve analysis was adopted to assess the diagnostic performance. Results : The results demonstrated that the difference in scatterer distributions between before and after compounding was greater for benign tumors than for malignant tumors. The FWHM ratio estimates for benign and malignant tumors were 0.76 ± 0.14 and 0.96 ± 0.06 (mean ± standard deviation), respectively (p < 0.01). The mean area under the ROC curve using the FWHM ratio estimates was 0.92, with a 95% confidence interval of 0.83–1.00. Conclusions : These findings indicate that the strain-compounding Nakagami imaging method based on the acquisition of multiple frames under different strain states could provide objective information that would improve the ability to classify benign and malignant breast tumors.
Bibliografie:	Telephone: +886‐3‐5715131 ext. 34240; Fax: +886‐3‐5718649. ckyeh@mx.nthu.edu.tw Author to whom correspondence should be addressed. Electronic mail ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0094-2405 2473-4209
DOI:	10.1118/1.3700167