The role of regional anaesthesia and multimodal analgesia in the prevention of chronic postoperative pain: a narrative review

Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury‐induced activation and sensitisation of bo...

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Vydáno v:Anaesthesia Ročník 76; číslo S1; s. 8 - 17
Hlavní autoři: Chen, Y.‐Y. K., Boden, K. A., Schreiber, K. L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.01.2021
Témata:
Analgesia
Analgesia - methods
Analgesics
Anesthesia
Anesthesia, Conduction - methods
Central nervous system
Chronic Pain - prevention & control
chronic postoperative pain
Heterogeneity
Humans
multimodal analgesia
Pain
Pain Management - methods
Pain perception
Pain, Postoperative - prevention & control
Postoperative period
Prevention
regional anaesthesia
Regional anesthesia
Risk assessment
Risk Factors
Taxonomy
chronic postoperative pain
regional anaesthesia
multimodal analgesia
ISSN:0003-2409, 1365-2044, 1365-2044
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Shrnutí:Summary Effective prevention of chronic postoperative pain is an important clinical goal, informed by a growing body of studies. Peri‐operative regional anaesthesia remains one of the most important tools in the multimodal analgesic toolbox, blocking injury‐induced activation and sensitisation of both the peripheral and central nervous system. We review the definition and taxonomy of chronic postoperative pain, its mechanistic basis and the most recent evidence for the preventative potential of multimodal analgesia, with a special focus on regional anaesthesia. While regional anaesthesia targets several important aspects of the mechanistic pathway leading to chronic postoperative pain, evidence for its efficacy is still mixed, possibly owing to the heterogeneity of risk profiles within the surgical patient, but also to variation in techniques and medications reported in the literature.
Bibliografie:ObjectType-Article-1
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ISSN:0003-2409
1365-2044
1365-2044
DOI:10.1111/anae.15256