Intraductal/ductal histology and lymphovascular invasion are associated with germline DNA‐repair gene mutations in prostate cancer

Background Germline mutations in genes mediating DNA repair are common in men with recurrent and advanced prostate cancer, and their presence may alter prognosis and management. We aimed to define pathological and clinical characteristics associated with germline DNA‐repair gene mutations, to facili...

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Vydáno v:	The Prostate Ročník 78; číslo 5; s. 401 - 407
Hlavní autoři:	Isaacsson Velho, Pedro, Silberstein, John L., Markowski, Mark C., Luo, Jun, Lotan, Tamara L., Isaacs, William B., Antonarakis, Emmanuel S.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Wiley Subscription Services, Inc 01.04.2018
Témata:	Adult Aged Aged, 80 and over BRCA1 protein BRCA2 protein cancer Deoxyribonucleic acid DNA DNA Repair Family medical history Genes Genetic counseling Genetic screening Germ-Line Mutation germline Histology Humans Lymph Nodes - pathology Lymphatic Metastasis Male Metastases Middle Aged Mutation mutations Neoplasm Metastasis Neoplasm Staging Nucleotide sequence prostate Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - pathology Retrospective Studies Saliva cancer prostate mutations germline DNA-repair
ISSN:	0270-4137, 1097-0045, 1097-0045
On-line přístup:	Získat plný text
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