Agent‐based computational model of retinal angiogenesis simulates microvascular network morphology as a function of pericyte coverage

Objective Define a role for perivascular cells during developmental retinal angiogenesis in the context of EC Notch1‐DLL4 signaling at the multicellular network level. Methods The retinal vasculature is highly sensitive to growth factor‐mediated intercellular signaling. Although EC signaling has bee...

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Bibliographic Details
Published in:	Microcirculation (New York, N.Y. 1994) Vol. 24; no. 8
Main Authors:	Walpole, Joseph, Mac Gabhann, Feilim, Peirce, Shayn M, Chappell, John C
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01.11.2017
Subjects:	agent‐based model Angiogenesis Animals Computer Simulation endothelial cell Intracellular Signaling Peptides and Proteins - metabolism Male Membrane Proteins - metabolism Mice Microcirculation - physiology Models, Cardiovascular Neovascularization, Physiologic pericyte Pericytes - metabolism Receptor, Notch1 - metabolism retina Retina - metabolism Retinal Vessels - physiology Signal Transduction - physiology agent-based model pericyte retina angiogenesis endothelial cell
ISSN:	1073-9688, 1549-8719, 1549-8719
Online Access:	Get full text
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