Inflammatory biomarkers of low back pain and disc degeneration: a review

Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine‐related disorders, including intervertebral disc degeneration,...

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Published in:Annals of the New York Academy of Sciences Vol. 1410; no. 1; pp. 68 - 84
Main Authors: Khan, Aysha N., Jacobsen, Hayley E., Khan, Jansher, Filippi, Christopher G., Levine, Mitchell, Lehman, Ronald A., Riew, K. Daniel, Lenke, Lawrence G., Chahine, Nadeen O.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.12.2017
Subjects:
Arthritis
Back pain
Biomarkers
Biomarkers - blood
Cytokines - blood
Degeneration
Diagnostic systems
Humans
Inflammation
Inflammation Mediators - blood
intervertebral disc degeneration
Intervertebral Disc Degeneration - blood
Intervertebral Disc Degeneration - diagnosis
Intervertebral Disc Degeneration - therapy
Intervertebral discs
Low back pain
Low Back Pain - blood
Low Back Pain - diagnosis
Low Back Pain - therapy
Outcome Assessment (Health Care) - methods
Pain
Pathogenesis
Population studies
Sensitivity and Specificity
Spinal stenosis
Spine
Surgical instruments
Symptomology
intervertebral disc degeneration
spine
back pain
inflammation
biomarkers
ISSN:0077-8923, 1749-6632, 1749-6632
Online Access:Get full text
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Abstract Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine‐related disorders, including intervertebral disc degeneration, disc herniation, spinal stenosis, and facet arthritis. The focus of these studies is inflammatory mediators, because inflammation contributes to the pathogenesis of disc degeneration and associated pain mechanisms. Increasingly, studies suggest that the presence of inflammatory mediators can be measured systemically in the blood. These biomarkers may serve as novel tools for directing patient care. Currently, patient response to treatment is unpredictable with a significant rate of recurrence, and, while surgical treatments may provide anatomical correction and pain relief, they are invasive and costly. The review covers studies performed on populations with specific diagnoses and undefined origins of LBP. Since the natural history of LBP is progressive, the temporal nature of studies is categorized by duration of symptomology/disease. Related studies on changes in biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of LBP and spinal degeneration have the potential to shepherd an era of individualized spine medicine for personalized therapeutics in the treatment of LBP.
AbstractList Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine‐related disorders, including intervertebral disc degeneration, disc herniation, spinal stenosis, and facet arthritis. The focus of these studies is inflammatory mediators, because inflammation contributes to the pathogenesis of disc degeneration and associated pain mechanisms. Increasingly, studies suggest that the presence of inflammatory mediators can be measured systemically in the blood. These biomarkers may serve as novel tools for directing patient care. Currently, patient response to treatment is unpredictable with a significant rate of recurrence, and, while surgical treatments may provide anatomical correction and pain relief, they are invasive and costly. The review covers studies performed on populations with specific diagnoses and undefined origins of LBP. Since the natural history of LBP is progressive, the temporal nature of studies is categorized by duration of symptomology/disease. Related studies on changes in biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of LBP and spinal degeneration have the potential to shepherd an era of individualized spine medicine for personalized therapeutics in the treatment of LBP.
Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine-related disorders, including intervertebral disc degeneration, disc herniation, spinal stenosis, and facet arthritis. The focus of these studies is inflammatory mediators, because inflammation contributes to the pathogenesis of disc degeneration and associated pain mechanisms. Increasingly, studies suggest that the presence of inflammatory mediators can be measured systemically in the blood. These biomarkers may serve as novel tools for directing patient care. Currently, patient response to treatment is unpredictable with a significant rate of recurrence, and, while surgical treatments may provide anatomical correction and pain relief, they are invasive and costly. The review covers studies performed on populations with specific diagnoses and undefined origins of LBP. Since the natural history of LBP is progressive, the temporal nature of studies is categorized by duration of symptomology/disease. Related studies on changes in biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of LBP and spinal degeneration have the potential to shepherd an era of individualized spine medicine for personalized therapeutics in the treatment of LBP.Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in human subjects. LBP is the leading cause of disability, caused by various spine-related disorders, including intervertebral disc degeneration, disc herniation, spinal stenosis, and facet arthritis. The focus of these studies is inflammatory mediators, because inflammation contributes to the pathogenesis of disc degeneration and associated pain mechanisms. Increasingly, studies suggest that the presence of inflammatory mediators can be measured systemically in the blood. These biomarkers may serve as novel tools for directing patient care. Currently, patient response to treatment is unpredictable with a significant rate of recurrence, and, while surgical treatments may provide anatomical correction and pain relief, they are invasive and costly. The review covers studies performed on populations with specific diagnoses and undefined origins of LBP. Since the natural history of LBP is progressive, the temporal nature of studies is categorized by duration of symptomology/disease. Related studies on changes in biomarkers with treatment are also reviewed. Ultimately, diagnostic biomarkers of LBP and spinal degeneration have the potential to shepherd an era of individualized spine medicine for personalized therapeutics in the treatment of LBP.
Author Khan, Aysha N.
Lenke, Lawrence G.
Lehman, Ronald A.
Jacobsen, Hayley E.
Levine, Mitchell
Chahine, Nadeen O.
Khan, Jansher
Filippi, Christopher G.
Riew, K. Daniel
AuthorAffiliation 2 Department of Orthopedic Surgery, Columbia University, New York, New York
1 The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York
4 New York Presbyterian – Spine Hospital, New York, New York
5 Department of Biomedical Engineering, Columbia University, New York, New York
3 Lenox Hill Hospital, Northwell Health, New York, New York
AuthorAffiliation_xml – name: 3 Lenox Hill Hospital, Northwell Health, New York, New York
– name: 4 New York Presbyterian – Spine Hospital, New York, New York
– name: 2 Department of Orthopedic Surgery, Columbia University, New York, New York
– name: 5 Department of Biomedical Engineering, Columbia University, New York, New York
– name: 1 The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York
Author_xml – sequence: 1
  givenname: Aysha N.
  surname: Khan
  fullname: Khan, Aysha N.
  organization: Northwell Health
– sequence: 2
  givenname: Hayley E.
  surname: Jacobsen
  fullname: Jacobsen, Hayley E.
  organization: Columbia University
– sequence: 3
  givenname: Jansher
  surname: Khan
  fullname: Khan, Jansher
  organization: Northwell Health
– sequence: 4
  givenname: Christopher G.
  surname: Filippi
  fullname: Filippi, Christopher G.
  organization: Northwell Health
– sequence: 5
  givenname: Mitchell
  surname: Levine
  fullname: Levine, Mitchell
  organization: Northwell Health
– sequence: 6
  givenname: Ronald A.
  surname: Lehman
  fullname: Lehman, Ronald A.
  organization: New York‐Presbyterian–Spine Hospital
– sequence: 7
  givenname: K. Daniel
  surname: Riew
  fullname: Riew, K. Daniel
  organization: New York‐Presbyterian–Spine Hospital
– sequence: 8
  givenname: Lawrence G.
  surname: Lenke
  fullname: Lenke, Lawrence G.
  organization: New York‐Presbyterian–Spine Hospital
– sequence: 9
  givenname: Nadeen O.
  orcidid: 0000-0002-0478-6042
  surname: Chahine
  fullname: Chahine, Nadeen O.
  email: noc7@columbia.edu
  organization: Columbia University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29265416$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords intervertebral disc degeneration
spine
back pain
inflammation
biomarkers
Language English
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2017 New York Academy of Sciences.
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Snippet Biomarkers are biological characteristics that can be used to indicate health or disease. This paper reviews studies on biomarkers of low back pain (LBP) in...
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StartPage 68
SubjectTerms Arthritis
Back pain
Biomarkers
Biomarkers - blood
Cytokines - blood
Degeneration
Diagnostic systems
Humans
Inflammation
Inflammation Mediators - blood
intervertebral disc degeneration
Intervertebral Disc Degeneration - blood
Intervertebral Disc Degeneration - diagnosis
Intervertebral Disc Degeneration - therapy
Intervertebral discs
Low back pain
Low Back Pain - blood
Low Back Pain - diagnosis
Low Back Pain - therapy
Outcome Assessment (Health Care) - methods
Pain
Pathogenesis
Population studies
Sensitivity and Specificity
Spinal stenosis
Spine
Surgical instruments
Symptomology
Title Inflammatory biomarkers of low back pain and disc degeneration: a review
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fnyas.13551
https://www.ncbi.nlm.nih.gov/pubmed/29265416
https://www.proquest.com/docview/1978549931
https://www.proquest.com/docview/1979495181
https://pubmed.ncbi.nlm.nih.gov/PMC5744892
Volume 1410
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