Cytologic characteristics of circulating epithelioid cells in pancreatic disease
BACKGROUND Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed th...
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| Veröffentlicht in: | Cancer Jg. 125; H. 5; S. 332 - 340 |
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| Abstract | BACKGROUND
Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin.
METHODS
Blood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size‐based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear‐to‐cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test.
RESULTS
No CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor.
CONCLUSIONS
CECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332–340. © 2017 American Cancer Society.
In the current study, circulating epithelioid cells (CECs) are isolated from blood in patients with both benign and malignant pancreatic disease at similar rates, but not isolated from healthy controls. These CECs appear to demonstrate no significant morphological differences between benign and malignant or between neoplastic and nonneoplastic diseases. |
|---|---|
| AbstractList | BACKGROUND
Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin.
METHODS
Blood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size‐based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear‐to‐cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test.
RESULTS
No CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor.
CONCLUSIONS
CECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332–340. © 2017 American Cancer Society.
In the current study, circulating epithelioid cells (CECs) are isolated from blood in patients with both benign and malignant pancreatic disease at similar rates, but not isolated from healthy controls. These CECs appear to demonstrate no significant morphological differences between benign and malignant or between neoplastic and nonneoplastic diseases. BACKGROUNDCirculating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin.METHODSBlood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size-based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear-to-cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test.RESULTSNo CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor.CONCLUSIONSCECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332-340. © 2017 American Cancer Society. BACKGROUND Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin. METHODS Blood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size-based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear-to-cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test. RESULTS No CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor. CONCLUSIONS CECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332-340. © 2017 American Cancer Society. In the current study, circulating epithelioid cells (CECs) are isolated from blood in patients with both benign and malignant pancreatic disease at similar rates, but not isolated from healthy controls. These CECs appear to demonstrate no significant morphological differences between benign and malignant or between neoplastic and nonneoplastic diseases. In the current study, circulating epithelioid cells (CECs) are isolated from blood in patients with both benign and malignant pancreatic disease at similar rates, but not isolated from healthy controls. These CECs appear to demonstrate no significant morphological differences between benign and malignant or between neoplastic and nonneoplastic diseases. Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a prognostic factor in various malignancies that can be isolated via various protocols. In the current study, the authors analyzed the cytomorphologic characteristics of CECs isolated by size in a cohort of patients with benign and malignant pancreatic diseases to determine whether cytomorphological features could predict CEC origin. Blood samples were collected from 9 healthy controls and 171 patients with pancreatic disease who were presenting for surgical evaluation before treatment. Blood was processed with the ScreenCell size-based filtration device. Evaluable CECs were analyzed in a blinded fashion for cytomorphologic characteristics, including cellularity; nucleoli; nuclear size, irregularity, variability, and hyperchromasia; and nuclear-to-cytoplasmic ratio. Statistical differences between variables were analyzed via the Fisher exact test. No CECs were identified among the 9 normal healthy controls. Of the 115 patients with CECs (positive or suspicious for), 25 had nonmalignant disease and 90 had malignancy. There were no significant differences in any of the cytologic criteria noted between groups divided by benign versus malignant, neoplastic versus nonneoplastic, or pancreatic ductal adenocarcinoma versus neuroendocrine tumor. CECs were observed in patients with malignant and nonmalignant pancreatic disease, but not in healthy controls. There were no morphologic differences observed between cells from different pancreatic diseases, suggesting that numerous conditions may be associated with CECs in the circulation and that care must be taken not to overinterpret cells identified by cytomorphology as indicative of circulating tumor cells of pancreatic cancer. Additional studies are required to determine the origin and clinical significance of these cells. Cancer Cytopathol 2017;125:332-340. © 2017 American Cancer Society. |
| Author | Rosenbaum, Matthew W. Castillo, Carlos Fernandez‐del Warshaw, Andrew L. Pitman, Martha B. Liss, Andrew S. Lillemoe, Keith D. Kulemann, Birte Cauley, Christy E. Thayer, Sarah P. |
| AuthorAffiliation | 2 Dept. of Surgery, Massachusetts General Hospital, Boston, MA 1 Dept. of Pathology, Massachusetts General Hospital, Boston, MA 4 Div. of Surgical Oncology and Surgery, University of Nebraska Medical Center, Omaha, NE 3 Dept. of Surgery, University Hospital Freiburg, Germany |
| AuthorAffiliation_xml | – name: 1 Dept. of Pathology, Massachusetts General Hospital, Boston, MA – name: 3 Dept. of Surgery, University Hospital Freiburg, Germany – name: 4 Div. of Surgical Oncology and Surgery, University of Nebraska Medical Center, Omaha, NE – name: 2 Dept. of Surgery, Massachusetts General Hospital, Boston, MA |
| Author_xml | – sequence: 1 givenname: Matthew W. orcidid: 0000-0001-8603-6538 surname: Rosenbaum fullname: Rosenbaum, Matthew W. email: Mrosenbaum2@partners.org organization: Massachusetts General Hospital – sequence: 2 givenname: Christy E. surname: Cauley fullname: Cauley, Christy E. organization: Massachusetts General Hospital – sequence: 3 givenname: Birte surname: Kulemann fullname: Kulemann, Birte organization: University Hospital Freiburg – sequence: 4 givenname: Andrew S. surname: Liss fullname: Liss, Andrew S. organization: Massachusetts General Hospital – sequence: 5 givenname: Carlos Fernandez‐del surname: Castillo fullname: Castillo, Carlos Fernandez‐del organization: Massachusetts General Hospital – sequence: 6 givenname: Andrew L. surname: Warshaw fullname: Warshaw, Andrew L. organization: Massachusetts General Hospital – sequence: 7 givenname: Keith D. surname: Lillemoe fullname: Lillemoe, Keith D. organization: Massachusetts General Hospital – sequence: 8 givenname: Sarah P. surname: Thayer fullname: Thayer, Sarah P. organization: Department of Surgery, University of Nebraska Medical Center – sequence: 9 givenname: Martha B. surname: Pitman fullname: Pitman, Martha B. organization: Massachusetts General Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28257167$$D View this record in MEDLINE/PubMed |
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| Keywords | circulating tumor cells (CTC) isolation by size of epithelial tumor cells (ISET) circulating epithelial cells (CEC) cytomorphological features pancreas |
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| Snippet | BACKGROUND
Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic... In the current study, circulating epithelioid cells (CECs) are isolated from blood in patients with both benign and malignant pancreatic disease at similar... Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic cells, are a... BACKGROUND Circulating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic... BACKGROUNDCirculating epithelioid cells (CECs), also known as circulating tumor, circulating cancer, circulating epithelial, or circulating nonhematologic... |
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| SubjectTerms | Adenocarcinoma - blood Adenocarcinoma - pathology Adenoma - blood Adenoma - pathology Ampulla of Vater - pathology Bile Duct Neoplasms - blood Bile Duct Neoplasms - pathology Cancer Carcinoma, Acinar Cell - blood Carcinoma, Acinar Cell - pathology Carcinoma, Pancreatic Ductal - blood Carcinoma, Pancreatic Ductal - pathology Case-Control Studies Cholangiocarcinoma - blood Cholangiocarcinoma - pathology circulating epithelial cells (CEC) circulating tumor cells (CTC) Common Bile Duct Neoplasms - blood Common Bile Duct Neoplasms - pathology Cystadenoma, Serous - blood Cystadenoma, Serous - pathology cytomorphological features Disease Epidermal Cyst Humans isolation by size of epithelial tumor cells (ISET) Neoplasms, Cystic, Mucinous, and Serous - blood Neoplasms, Cystic, Mucinous, and Serous - pathology Neoplastic Cells, Circulating - pathology Neuroendocrine Tumors - blood Neuroendocrine Tumors - pathology pancreas Pancreatic cancer Pancreatic Diseases - blood Pancreatic Diseases - pathology Pancreatic Neoplasms - blood Pancreatic Neoplasms - pathology Pancreatitis, Chronic - blood Pancreatitis, Chronic - pathology Prognosis Splenic Diseases |
| Title | Cytologic characteristics of circulating epithelioid cells in pancreatic disease |
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