Antiretroviral protease inhibitors induce features of cellular senescence that are reversible upon drug removal

Antiretroviral drugs have dramatically improved the prognosis of HIV‐infected patients, with strikingly reduced morbidity and mortality. However, long‐term use can be associated with signs of premature aging. Highly active antiretroviral therapy generally comprises two nucleoside reverse transcripta...

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Bibliographic Details
Published in:	Aging cell Vol. 22; no. 1; pp. e13750 - n/a
Main Authors:	Kuehnemann, Chisaka, Hughes, Jun‐Wei B., Desprez, Pierre‐Yves, Melov, Simon, Wiley, Christopher D., Campisi, Judith
Format:	Journal Article
Language:	English
Published:	England John Wiley & Sons, Inc 01.01.2023 John Wiley and Sons Inc
Subjects:	Acquired immune deficiency syndrome Aging Aging, Premature AIDS Animals Anti-HIV Agents - pharmacology Anti-HIV Agents - therapeutic use Antiretroviral agents antiretroviral drug Atazanavir Sulfate - pharmacology Atazanavir Sulfate - therapeutic use Cell culture Cellular Senescence Chronic illnesses Cytokines Darunavir - pharmacology Darunavir - therapeutic use Drug therapy Fibroblasts Genotype & phenotype Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use Human immunodeficiency virus Immune system Infections inflammation Kinases Mice Mitochondria Morbidity Morphology Nucleoside reverse transcriptase inhibitors Phenotypes Physiology Proteinase inhibitors Ritonavir Ritonavir - pharmacology Ritonavir - therapeutic use RNA-directed DNA polymerase Senescence senescence‐associated secretory phenotype Stains & staining human immunodeficiency virus antiretroviral drug aging senescence-associated secretory phenotype inflammation
ISSN:	1474-9718, 1474-9726, 1474-9726
Online Access:	Get full text
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