In vivo glia‐to‐neuron conversion: pitfalls and solutions

Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia‐to‐neuron (GtN) conversion emerges as a potential solution for regeneration‐based therapeutics. This approach tak...

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Veröffentlicht in:Developmental neurobiology (Hoboken, N.J.) Jg. 82; H. 5; S. 367 - 374
Hauptverfasser: Wang, Lei‐Lei, Zhang, Chun‐Li
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Wiley Subscription Services, Inc 01.07.2022
Schlagworte:
BrdU
Cell Differentiation
Cell fate
Cellular Reprogramming
Functional morphology
Glial cells
glia‐to‐neuron (GtN) conversion
Humans
in vivo reprogramming
lineage tracing
Nerve Degeneration
Neural networks
NEUROD1
Neuroglia
Neuronal-glial interactions
Neurons - physiology
PTBP1
Regeneration
NEUROD1
PTBP1
in vivo reprogramming
lineage tracing
glia-to-neuron (GtN) conversion
BrdU
ISSN:1932-8451, 1932-846X, 1932-846X
Online-Zugang:Volltext
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Zusammenfassung:Neuron loss and disruption of neural circuits are associated with many neurological conditions. A key question is how to rebuild neural circuits for functional improvements. In vivo glia‐to‐neuron (GtN) conversion emerges as a potential solution for regeneration‐based therapeutics. This approach takes advantage of the regenerative ability of resident glial cells to produce new neurons through cell fate reprogramming. Significant progress has been made over the years in this emerging field. However, inappropriate analysis often leads to misleading conclusions that create confusion and hype. In this perspective, we point out the most salient pitfalls associated with some recent studies and provide solutions to prevent them in the future. The goal is to foster healthy development of this promising field and lay a solid cellular foundation for future regeneration‐based medicine.
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ISSN:1932-8451
1932-846X
1932-846X
DOI:10.1002/dneu.22880