The Conundrum of Genetic "Drivers" in Benign Conditions

Advances in deep genomic sequencing have identified a spectrum of cancer-specific passenger and driver aberrations. Clones with driver anomalies are believed to be positively selected during carcinogenesis. Accumulating evidence, however, shows that genomic alterations, such as those inBRAF,RAS,EGFR...

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Bibliographic Details
Published in:	JNCI : Journal of the National Cancer Institute Vol. 108; no. 8
Main Authors:	Kato, Shumei, Lippman, Scott M, Flaherty, Keith T, Kurzrock, Razelle
Format:	Journal Article
Language:	English
Published:	United States 01.08.2016
Subjects:	Carcinogenesis - genetics Class I Phosphatidylinositol 3-Kinases Cyclin-Dependent Kinase Inhibitor p18 - genetics Gene Rearrangement GTP-Binding Protein alpha Subunits, Gq-G11 - genetics Humans Mutation Neoplasms - genetics Neoplasms - prevention & control Neurofibromin 1 - genetics Neurofibromin 2 - genetics Phosphatidylinositol 3-Kinases - genetics Precancerous Conditions - genetics Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, ErbB-2 - genetics Receptor, Fibroblast Growth Factor, Type 3 - genetics Tumor Suppressor Protein p53 - genetics
ISSN:	1460-2105, 1460-2105
Online Access:	Get more information
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