The Conundrum of Genetic "Drivers" in Benign Conditions

Advances in deep genomic sequencing have identified a spectrum of cancer-specific passenger and driver aberrations. Clones with driver anomalies are believed to be positively selected during carcinogenesis. Accumulating evidence, however, shows that genomic alterations, such as those inBRAF,RAS,EGFR...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	JNCI : Journal of the National Cancer Institute Ročník 108; číslo 8
Hlavní autoři:	Kato, Shumei, Lippman, Scott M, Flaherty, Keith T, Kurzrock, Razelle
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2016
Témata:	Carcinogenesis - genetics Class I Phosphatidylinositol 3-Kinases Cyclin-Dependent Kinase Inhibitor p18 - genetics Gene Rearrangement GTP-Binding Protein alpha Subunits, Gq-G11 - genetics Humans Mutation Neoplasms - genetics Neoplasms - prevention & control Neurofibromin 1 - genetics Neurofibromin 2 - genetics Phosphatidylinositol 3-Kinases - genetics Precancerous Conditions - genetics Proto-Oncogene Proteins B-raf - genetics ras Proteins - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, ErbB-2 - genetics Receptor, Fibroblast Growth Factor, Type 3 - genetics Tumor Suppressor Protein p53 - genetics
ISSN:	1460-2105, 1460-2105
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Buďte první, kdo okomentuje tento záznam!