Heterogeneous differentiation patterns of individual CD8+ T cells

Upon infection, antigen-specific CD8(+) T lymphocyte responses display a highly reproducible pattern of expansion and contraction that is thought to reflect a uniform behavior of individual cells. We tracked the progeny of individual mouse CD8(+) T cells by in vivo lineage tracing and demonstrated t...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 340; no. 6132; p. 635
Main Authors:	Gerlach, Carmen, Rohr, Jan C, Perié, Leïla, van Rooij, Nienke, van Heijst, Jeroen W J, Velds, Arno, Urbanus, Jos, Naik, Shalin H, Jacobs, Heinz, Beltman, Joost B, de Boer, Rob J, Schumacher, Ton N M
Format:	Journal Article
Language:	English
Published:	United States 03.05.2013
Subjects:	Adoptive Transfer Animals Asymmetric Cell Division CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Differentiation Cell Lineage Cell Proliferation Immunity, Cellular Immunologic Memory Immunophenotyping Listeria monocytogenes Listeriosis - immunology Mice Mice, Inbred C57BL Mice, Transgenic Models, Immunological Receptors, Antigen, T-Cell - immunology Single-Cell Analysis Stochastic Processes T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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