Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids

Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. T...

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Published in:Biochemical journal Vol. 476; no. 1; p. 1
Main Authors: Dickson, Eamonn J, Hille, Bertil
Format: Journal Article
Language:English
Published: England 07.01.2019
Subjects:
Animals
Cell Membrane - metabolism
Humans
Membrane Proteins - metabolism
Phosphatidylinositols - metabolism
Signal Transduction
transmembrane proteins
PTEN
phosphatidylinositol
lipid transfer
phosphoinositide 3-kinase
ISSN:1470-8728, 1470-8728
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Abstract Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
AbstractList Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small fraction to the bulk of cellular phospholipids, they make remarkable contributions to practically all aspects of a cell's life and death. They do so by recruiting cytoplasmic proteins/effectors or by interacting with cytoplasmic domains of membrane proteins at the membrane-cytoplasm interface to organize and mold organelle identity. The present study summarizes aspects of our current understanding concerning the metabolism, manipulation, measurement, and intimate roles these lipids play in regulating membrane homeostasis and vital cell signaling reactions in health and disease.
Author Hille, Bertil
Dickson, Eamonn J
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  givenname: Eamonn J
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  surname: Dickson
  fullname: Dickson, Eamonn J
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  organization: Department of Physiology and Membrane Biology, University of California Davis, Davis, CA 95616, U.S.A. ejdickson@ucdavis.edu
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  givenname: Bertil
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  surname: Hille
  fullname: Hille, Bertil
  organization: Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, U.S.A
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Keywords transmembrane proteins
PTEN
phosphatidylinositol
lipid transfer
phosphoinositide 3-kinase
Language English
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Snippet Polyphosphoinositides (PPIs) are essential phospholipids located in the cytoplasmic leaflet of eukaryotic cell membranes. Despite contributing only a small...
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SubjectTerms Animals
Cell Membrane - metabolism
Humans
Membrane Proteins - metabolism
Phosphatidylinositols - metabolism
Signal Transduction
Title Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids
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