Molecular basis for specificity of the Met1-linked polyubiquitin signal

The post-translational modification of proteins provides a rapid and versatile system for regulating all signalling pathways. Protein ubiquitination is one such type of post-translational modification involved in controlling numerous cellular processes. The unique ability of ubiquitin to form polyub...

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Vydáno v:Biochemical Society transactions Ročník 44; číslo 6; s. 1581 - 1602
Hlavní autor: Elliott, Paul R
Médium: Journal Article
Jazyk:angličtina
Vydáno: England 15.12.2016
Témata:
Animals
Binding Sites - genetics
Endopeptidases - chemistry
Endopeptidases - genetics
Endopeptidases - metabolism
Humans
Methionine - genetics
Methionine - metabolism
Models, Molecular
Polyubiquitin - chemistry
Polyubiquitin - genetics
Polyubiquitin - metabolism
Protein Domains
Signal Transduction
Ubiquitin-Protein Ligases - chemistry
Ubiquitin-Protein Ligases - genetics
Ubiquitin-Protein Ligases - metabolism
Ubiquitinated Proteins - chemistry
Ubiquitinated Proteins - genetics
Ubiquitinated Proteins - metabolism
inflammation
ubiquitin signalling
post-translational modification
ISSN:1470-8752
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Shrnutí:The post-translational modification of proteins provides a rapid and versatile system for regulating all signalling pathways. Protein ubiquitination is one such type of post-translational modification involved in controlling numerous cellular processes. The unique ability of ubiquitin to form polyubiquitin chains creates a highly complex code responsible for different subsequent signalling outcomes. Specialised enzymes ('writers') generate the ubiquitin code, whereas other enzymes ('erasers') disassemble it. Importantly, the ubiquitin code is deciphered by different ubiquitin-binding proteins ('readers') functioning to elicit particular cellular responses. Ten years ago, the methionine1 (Met1)-linked (linear) polyubiquitin code was first identified and the intervening years have witnessed a seismic shift in our understanding of Met1-linked polyubiquitin in cellular processes, particularly inflammatory signalling. This review will discuss the molecular mechanisms of specificity determination within Met1-linked polyubiquitin signalling.
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ISSN:1470-8752
DOI:10.1042/bst20160227