Links between the unfolded protein response and the DNA damage response in hypoxia: a systematic review

Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological hypoxia (<0.1% O2) cells become up to three times more resistant to radiation. The biological response to radiobiological hypoxia is one of few physiologically relevant stresses that activates both the...

Full description

Saved in:

Bibliographic Details
Published in:	Biochemical Society transactions Vol. 49; no. 3; p. 1251
Main Authors:	Bolland, Hannah, Ma, Tiffany S, Ramlee, Syafiq, Ramadan, Kristijan, Hammond, Ester M
Format:	Journal Article
Language:	English
Published:	England 30.06.2021
Subjects:	Animals Apoptosis - genetics Cell Line, Tumor DNA Damage Humans Hypoxia - genetics Hypoxia - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Signal Transduction - genetics Unfolded Protein Response - genetics ER stress hypoxia replication stress DDR radiation UPR
ISSN:	1470-8752, 1470-8752
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!