Safety and efficacy of pembrolizumab, radiation therapy, and surgery versus radiation therapy and surgery for stage III soft tissue sarcoma of the extremity (SU2C-SARC032): an open-label, randomised clinical trial

Approximately half of patients with localised, high-risk soft tissue sarcoma of the extremity develop metastases. We aimed to assess whether the addition of pembrolizumab to preoperative radiotherapy and surgery would improve disease-free survival. We completed an open-label, randomised clinical tri...

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Bibliographic Details
Published in:	The Lancet (British edition) Vol. 404; no. 10467; pp. 2053 - 2064
Main Authors:	Mowery, Yvonne M, Ballman, Karla V, Hong, Angela M, Schuetze, Scott M, Wagner, Andrew J, Monga, Varun, Heise, Rachel S, Attia, Steven, Choy, Edwin, Burgess, Melissa A, Bae, Susie, Pryor, David I, Van Tine, Brian A, Tinoco, Gabriel, Chmielowski, Bartosz, Freeman, Carolyn, Gronchi, Alessandro, Meyer, Christian F, Dickson, Mark A, Hartner, Lee, Davis, Lara E, Powers, Benjamin C, Moding, Everett J, Weinhold, Kent J, van de Rijn, Matt, Brigman, Brian E, Riedel, Richard F, Kirsch, David G
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 23.11.2024 Elsevier Limited
Subjects:	Adult Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - therapeutic use Antineoplastic Agents, Immunological - adverse effects Antineoplastic Agents, Immunological - therapeutic use Cancer surgery Cancer therapies Cell death Chemotherapy Clinical outcomes Clinical trials Combined Modality Therapy Disease control Disease-Free Survival Extremities Female Health services Histology Humans Immunotherapy Labels Liposarcoma Male Metastases Metastasis Middle Aged Monoclonal antibodies Neoadjuvant Therapy - methods Neoplasm Staging Oncology Patients Pembrolizumab Radiation dosage Radiation therapy Sarcoma Sarcoma - drug therapy Sarcoma - mortality Sarcoma - radiotherapy Sarcoma - therapy Soft tissue sarcoma Soft tissues Surgery Survival Targeted cancer therapy Toxicity Treatment Outcome
ISSN:	0140-6736, 1474-547X, 1474-547X
Online Access:	Get full text
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