The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease
In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid the foundation for the sequence-structure-function paradigm, which states that the sequence of a protein determines its structure, and structu...
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| Published in: | Biochemical Society transactions Vol. 44; no. 5; pp. 1185 - 1200 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
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15.10.2016
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| ISSN: | 1470-8752 |
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| Abstract | In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid the foundation for the sequence-structure-function paradigm, which states that the sequence of a protein determines its structure, and structure determines function. However, a class of polypeptide segments called intrinsically disordered regions does not conform to this postulate. In this review, I will first describe established and emerging ideas about how disordered regions contribute to protein function. I will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease and the emergence of cellular complexity during organismal evolution. |
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| AbstractList | In the 1960s, Christian Anfinsen postulated that the unique three-dimensional structure of a protein is determined by its amino acid sequence. This work laid the foundation for the sequence-structure-function paradigm, which states that the sequence of a protein determines its structure, and structure determines function. However, a class of polypeptide segments called intrinsically disordered regions does not conform to this postulate. In this review, I will first describe established and emerging ideas about how disordered regions contribute to protein function. I will then discuss molecular principles by which regulatory mechanisms, such as alternative splicing and asymmetric localization of transcripts that encode disordered regions, can increase the functional versatility of proteins. Finally, I will discuss how disordered regions contribute to human disease and the emergence of cellular complexity during organismal evolution. |
| Author | Babu, M Madan |
| Author_xml | – sequence: 1 givenname: M Madan surname: Babu fullname: Babu, M Madan organization: MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, U.K |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27911701$$D View this record in MEDLINE/PubMed |
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| Title | The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease |
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