Cardiac Tissue Chips (CTCs) for Modeling Cardiovascular Disease

Objective: Cardiovascular research and regenerative strategies have been significantly limited by the lack of relevant cell culture models that can recreate complex hemodynamic stresses associated with pressure-volume changes in the heart. Methods: To address this issue, we designed a biomimetic car...

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Bibliographic Details
Published in:	IEEE transactions on biomedical engineering Vol. 66; no. 12; pp. 3436 - 3443
Main Authors:	Rogers, Aaron J., Miller, Jessica M., Kannappan, Ramaswamy, Sethu, Palaniappan
Format:	Journal Article
Language:	English
Published:	United States IEEE 01.12.2019 The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
Subjects:	Animals Aspect ratio Biomimetics Blood pressure cardiac disease models Cardiac tissue Cardiomyopathy Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - physiopathology Cell culture Cells, Cultured Diastolic pressure Dilated cardiomyopathy Disease control Elongation Engineered cardiac tissue Equipment Design Fibers Fibroblasts - cytology Fibrosis Gene expression Heart Heart - physiology Heart function Heart rate Hemodynamics Load modeling Mechanical unloading Microfluidics Modelling Models, Cardiovascular Myocardium - cytology Pathology Rats Stress Stresses Systolic pressure Three dimensional models Tissue Array Analysis - instrumentation Tissue Array Analysis - methods tissue chips Tissue Culture Techniques - instrumentation Tissue Culture Techniques - methods Ventricle
ISSN:	0018-9294, 1558-2531, 1558-2531
Online Access:	Get full text
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