Acute Stress Suppresses Synaptic Inhibition and Increases Anxiety via Endocannabinoid Release in the Basolateral Amygdala

Stress and glucocorticoids stimulate the rapid mobilization of endocannabinoids in the basolateral amygdala (BLA). Cannabinoid receptors in the BLA contribute to anxiogenesis and fear-memory formation. We tested for rapid glucocorticoid-induced endocannabinoid regulation of synaptic inhibition in th...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 36; no. 32; p. 8461
Main Authors:	Di, Shi, Itoga, Christy A, Fisher, Marc O, Solomonow, Jonathan, Roltsch, Emily A, Gilpin, Nicholas W, Tasker, Jeffrey G
Format:	Journal Article
Language:	English
Published:	United States 10.08.2016
Subjects:	Animals Antiemetics - pharmacology Anxiety - pathology Anxiety - physiopathology Arachidonic Acids - pharmacology Basolateral Nuclear Complex - drug effects Basolateral Nuclear Complex - metabolism Benzoxazines - pharmacology Calcium Channel Blockers - pharmacology Cannabinoid Receptor Agonists - pharmacology Cannabinoid Receptor Antagonists - pharmacology Dexamethasone - pharmacology Disease Models, Animal Endocannabinoids - metabolism Endocannabinoids - pharmacology Enzyme Inhibitors - pharmacology Glucocorticoids - pharmacology Glycerides - pharmacology Inhibitory Postsynaptic Potentials - drug effects Male Morpholines - pharmacology Naphthalenes - pharmacology Piperidines - pharmacology Pyrazoles - pharmacology Rats Rats, Wistar Restraint, Physical - physiology Rimonabant Synaptic Transmission amygdala glucocorticoid CB1 cannabinoid GABA corticosteroid LTD
ISSN:	1529-2401, 1529-2401
Online Access:	Get more information
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