Enhancing pressure ulcer healing and tissue regeneration by using N-acetyl-cysteine loaded carboxymethyl cellulose/gelatin/sodium alginate hydrogel
Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the hea...
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| Veröffentlicht in: | Biomedical engineering letters Jg. 14; H. 4; S. 833 - 845 |
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The Korean Society of Medical and Biological Engineering
01.07.2024
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| Abstract | Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel
®
, and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing. |
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| AbstractList | Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel®, and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing. Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel ® , and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing. Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel , and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing. Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel®, and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing.Prolonged pressure on the skin can result in pressure ulcers, which may lead to serious complications, such as infection and tissue damage. In this study, we evaluated the effect of a carboxymethyl cellulose/gelatin/sodium alginate (CMC/Gel/Alg) hydrogel containing N-acetyl-cysteine (NAC) on the healing of pressure ulcers. Pressure ulcers were induced by applying a magnet to the dorsum of rat skin. The wounds were then treated with sterile gauze, ChitoHeal Gel®, and CMC/Gel/Alg hydrogel dressings with or without NAC for the other groups. We evaluated the morphology, weight loss, swelling, rheology, blood compatibility, cytocompatibility, antioxidant capacity, and wound scratch of the prepared hydrogel. MTT assay revealed that the optimum concentration of NAC was 5 mg/ml, which induced higher cell proliferation and viability. Results of the histopathological evaluation showed increased wound closure, and complete re-epithelialization in the hydrogel-containing NAC group compared to the other groups. The CMC/Gel/Alg/5 mg/ml NAC hydrogel dressing showed 84% wound closure at 14 days after treatment. Immunohistochemical results showed a decrease in the level of TNF-α on day 14 compared day 7. Results of the qPCR assay revealed that NAC hydrogel increased the expression of Collagen type I and TGF-β1 and decreased MMP2 and MMP9 mRNA on the 14th day. The results suggest that the CMC/Gel/Alg/5 mg/ml NAC hydrogel with antioxidant properties is an appropriate dressing for wound healing. |
| Author | kamalabadi-Farahani, Mohammad Salehi, Majid Alizadeh, Akram Aldaghi, Niloofar Alizadeh, Morteza |
| Author_xml | – sequence: 1 givenname: Niloofar orcidid: 0000-0002-0592-120X surname: Aldaghi fullname: Aldaghi, Niloofar organization: Student Research Committee, School of Medicine, Shahroud University of Medical Sciences – sequence: 2 givenname: Mohammad orcidid: 0000-0002-4768-2577 surname: kamalabadi-Farahani fullname: kamalabadi-Farahani, Mohammad organization: Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences – sequence: 3 givenname: Morteza orcidid: 0000-0003-4214-6502 surname: Alizadeh fullname: Alizadeh, Morteza organization: Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences – sequence: 4 givenname: Akram orcidid: 0000-0002-9956-4556 surname: Alizadeh fullname: Alizadeh, Akram organization: Nervous System Stem Cells Research Center, Semnan University of Medical Sciences, Department of Tissue Engineering and Applied Cell Sciences, Faculty of Medicine, Semnan University of Medical Sciences – sequence: 5 givenname: Majid orcidid: 0000-0001-6283-8181 surname: Salehi fullname: Salehi, Majid email: Msalehi.te1392@gmail.com organization: Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Health Technology Incubator Center, Shahroud University of Medical Sciences, Sexual Health and Fertility Research Center, Shahroud University of Medical Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38946815$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1111_exd_70148 crossref_primary_10_1016_j_ijbiomac_2024_135418 crossref_primary_10_3389_fimmu_2024_1485523 crossref_primary_10_1016_j_carres_2025_109673 crossref_primary_10_1016_j_burns_2025_107700 |
| Cites_doi | 10.3390/ijerph19031338 10.1111/iwj.12557 10.1007/s00441-012-1410-z 10.1002/app.50225 10.1186/s12903-022-02433-6 10.1038/eye.2012.135 10.1515/tjb-2017-0046 10.4103/0970-0358.101287 10.1080/10790268.2021.1916155 10.1007/s00011-011-0323-8 10.1016/j.ibmb.2012.08.001 10.1080/08941930490472046 10.3390/biom13030444 10.3390/ijms15057563 10.1016/j.ijbiomac.2021.02.133 10.1055/s-0042-1744427 10.2147/IJN.S232190 10.3390/biomedicines10040856 10.1038/sj.jid.5700765 10.1155/2017/5192924 10.1016/j.carbpol.2016.04.073 10.1007/s10924-023-02796-z 10.1038/s41598-020-58452-2 10.1016/j.clindermatol.2006.12.005 10.3390/polym13172959 10.1073/pnas.83.12.4167 10.1089/wound.2012.0406 10.3390/antiox10071013 10.1038/nprot.2007.30 10.1016/j.jtv.2017.01.002 10.1016/j.ijbiomac.2020.07.160 10.1083/jcb.201305074 10.1007/s11010-005-3178-x 10.1093/rb/rbab003 10.3390/polym15092149 10.2353/ajpath.2009.081080 10.1186/s12951-023-02054-3 10.1002/jcp.20948 10.3390/cells9020306 10.3390/gels8020127 10.3390/antiox10060967 10.1002/jcp.21160 10.1016/B978-0-323-52727-9.00016-9 |
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| Keywords | Carboxymethyl cellulose Wound healing N-acetyl-cysteine Hydrogel Pressure ulcer |
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| References | Martins, Caley, O'Toole (CR42) 2013; 351 Abdulrab (CR24) 2022; 22 Tenório (CR29) 2021; 10 Roberts (CR35) 1986; 83 Ramaesh (CR45) 2012; 26 Ndlovu (CR11) 2021; 13 Menke (CR33) 2007; 25 Pakyari (CR36) 2013; 2 Kim (CR38) 2022; 49 Sarika, James (CR20) 2016; 148 Yan, Boyd (CR34) 2007; 211 Liang, Park, Guan (CR15) 2007; 2 Li (CR32) 2020; 2020 Markiewicz-Gospodarek (CR1) 2022; 19 Jansen (CR43) 2007; 127 Zhang (CR10) 2023; 15 Castro (CR25) 2015; 30 Moses (CR21) 2023; 13 Palacio, Markert, Martínez (CR30) 2011; 60 Liarte, Bernabé-García, Nicolás (CR37) 2020; 9 Shirinsokhan (CR47) 2020; 22 Fischak (CR13) 2017; 2017 Sawicki (CR41) 2005; 269 Agrawal, Chauhan (CR2) 2012; 45 Dunnill (CR28) 2017; 14 Stadler (CR17) 2004; 17 Choudhary (CR19) 2021; 178 Salehi (CR8) 2021; 138 Perez-Lopez (CR7) 2023; 46 Tsai (CR6) 2014; 15 Kumar (CR5) 2021; 10 Holzer-Geissler (CR27) 2022; 10 El Sayed (CR9) 2023; 31 Zhou (CR18) 2023; 21 CR23 O'Toole (CR44) 2008; 214 Ahmadi Ashtiani (CR16) 2019; 18 Kanikireddy (CR12) 2020; 164 Qian (CR14) 2021; 8 Ponugoti (CR26) 2013; 203 Santos (CR31) 2017; 26 Hou (CR4) 2020; 15 Firlar (CR22) 2022; 8 Mitten, Jing, Suzuki (CR39) 2012; 42 Yamazaki (CR3) 2020; 10 Hattori (CR40) 2009; 175 Aslantaş (CR46) 2018; 43 NB Menke (378_CR33) 2007; 25 EK Mitten (378_CR39) 2012; 42 A Markiewicz-Gospodarek (378_CR1) 2022; 19 VL Martins (378_CR42) 2013; 351 PR Sarika (378_CR20) 2016; 148 M Tenório (378_CR29) 2021; 10 S Kim (378_CR38) 2022; 49 N Hattori (378_CR40) 2009; 175 378_CR23 S Yamazaki (378_CR3) 2020; 10 K Agrawal (378_CR2) 2012; 45 ML Tsai (378_CR6) 2014; 15 X Li (378_CR32) 2020; 2020 S Kumar (378_CR5) 2021; 10 EE Aslantaş (378_CR46) 2018; 43 JCJ Holzer-Geissler (378_CR27) 2022; 10 C Fischak (378_CR13) 2017; 2017 S Liarte (378_CR37) 2020; 9 S Abdulrab (378_CR24) 2022; 22 C Yan (378_CR34) 2007; 211 T Ramaesh (378_CR45) 2012; 26 I Stadler (378_CR17) 2004; 17 M Pakyari (378_CR36) 2013; 2 J Hou (378_CR4) 2020; 15 M Choudhary (378_CR19) 2021; 178 SP Ndlovu (378_CR11) 2021; 13 MM El Sayed (378_CR9) 2023; 31 H Ahmadi Ashtiani (378_CR16) 2019; 18 AB Roberts (378_CR35) 1986; 83 J Zhou (378_CR18) 2023; 21 V Kanikireddy (378_CR12) 2020; 164 RL Moses (378_CR21) 2023; 13 B Ponugoti (378_CR26) 2013; 203 C Dunnill (378_CR28) 2017; 14 S Zhang (378_CR10) 2023; 15 G Sawicki (378_CR41) 2005; 269 B Qian (378_CR14) 2021; 8 EM Santos (378_CR31) 2017; 26 I Firlar (378_CR22) 2022; 8 JR Palacio (378_CR30) 2011; 60 PL Jansen (378_CR43) 2007; 127 M Salehi (378_CR8) 2021; 138 A Shirinsokhan (378_CR47) 2020; 22 S Perez-Lopez (378_CR7) 2023; 46 C-C Liang (378_CR15) 2007; 2 B Castro (378_CR25) 2015; 30 EA O'Toole (378_CR44) 2008; 214 |
| References_xml | – volume: 19 start-page: 1338 issue: 3 year: 2022 ident: CR1 article-title: Burn wound healing: clinical complications, medical care, treatment, and dressing types: the current state of knowledge for clinical practice publication-title: Int J Environ Res Public Health doi: 10.3390/ijerph19031338 – volume: 14 start-page: 89 issue: 1 year: 2017 end-page: 96 ident: CR28 article-title: Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process publication-title: Int Wound J doi: 10.1111/iwj.12557 – volume: 351 start-page: 255 issue: 2 year: 2013 end-page: 268 ident: CR42 article-title: Matrix metalloproteinases and epidermal wound repair publication-title: Cell Tissue Res doi: 10.1007/s00441-012-1410-z – volume: 138 start-page: 50225 issue: 16 year: 2021 ident: CR8 article-title: Chitosan hydrogel loaded with aloe vera gel and tetrasodium ethylenediaminetetraacetic acid (EDTA) as the wound healing material: in vitro and in vivo study publication-title: J Appl Polym Sci doi: 10.1002/app.50225 – volume: 22 start-page: 398 issue: 1 year: 2022 ident: CR24 article-title: Antibacterial and anti-inflammatory efficacy of N-acetyl cysteine in endodontic treatment: a scoping review publication-title: BMC Oral Health doi: 10.1186/s12903-022-02433-6 – volume: 26 start-page: 1138 issue: 8 year: 2012 end-page: 1144 ident: CR45 article-title: Effects of N-acetylcysteine on matrix metalloproteinase-9 secretion and cell migration of human corneal epithelial cells publication-title: Eye doi: 10.1038/eye.2012.135 – volume: 43 start-page: 571 issue: 6 year: 2018 end-page: 577 ident: CR46 article-title: Effects of calcium hydroxide and N-acetylcysteine on MMP-2, MMP-9, TIMP-1 and TIMP-2 in LPS-stimulated macrophage cell lines publication-title: Turk J Biochem doi: 10.1515/tjb-2017-0046 – volume: 45 start-page: 244 issue: 2 year: 2012 end-page: 254 ident: CR2 article-title: Pressure ulcers: back to the basics publication-title: Indian J Plast Surg doi: 10.4103/0970-0358.101287 – volume: 46 start-page: 194 issue: 2 year: 2023 end-page: 203 ident: CR7 article-title: Stem cell and tissue engineering approaches in pressure ulcer treatment publication-title: J Spinal Cord Med doi: 10.1080/10790268.2021.1916155 – volume: 60 start-page: 695 issue: 7 year: 2011 end-page: 704 ident: CR30 article-title: Anti-inflammatory properties of N-acetylcysteine on lipopolysaccharide-activated macrophages publication-title: Inflamm Res doi: 10.1007/s00011-011-0323-8 – volume: 42 start-page: 854 issue: 11 year: 2012 end-page: 864 ident: CR39 article-title: Matrix metalloproteinases (MMPs) are required for wound closure and healing during larval leg regeneration in the flour beetle, Tribolium castaneum publication-title: Insect Biochem Mol Biol doi: 10.1016/j.ibmb.2012.08.001 – volume: 17 start-page: 221 issue: 4 year: 2004 end-page: 227 ident: CR17 article-title: Development of a simple, noninvasive, clinically relevant model of pressure ulcers in the mouse publication-title: J Invest Surg doi: 10.1080/08941930490472046 – volume: 13 start-page: 444 issue: 3 year: 2023 ident: CR21 article-title: Evidence for natural products as alternative wound-healing therapies publication-title: Biomolecules doi: 10.3390/biom13030444 – volume: 15 start-page: 7563 issue: 5 year: 2014 end-page: 7578 ident: CR6 article-title: Topical N-acetylcysteine accelerates wound healing in vitro and in vivo via the PKC/Stat3 pathway publication-title: Int J Mol Sci doi: 10.3390/ijms15057563 – volume: 178 start-page: 41 year: 2021 end-page: 52 ident: CR19 article-title: Scar free healing of full thickness diabetic wounds: a unique combination of silver nanoparticles as antimicrobial agent, calcium alginate nanoparticles as hemostatic agent, fresh blood as nutrient/growth factor supplier and chitosan as base matrix publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2021.02.133 – volume: 49 start-page: 275 issue: 2 year: 2022 end-page: 284 ident: CR38 article-title: Novel three-dimensional knitted fabric for pressure ulcer prevention: preliminary clinical application and testing in a diabetic mouse model of pressure ulcers publication-title: Arch Plast Surg doi: 10.1055/s-0042-1744427 – volume: 15 start-page: 1349 year: 2020 end-page: 1361 ident: CR4 article-title: Multi-layered polyamide/collagen scaffolds with topical sustained release of N-acetylcysteine for promoting wound healing publication-title: Int J Nanomed doi: 10.2147/IJN.S232190 – volume: 10 start-page: 856 issue: 4 year: 2022 ident: CR27 article-title: The impact of prolonged inflammation on wound healing publication-title: Biomedicines doi: 10.3390/biomedicines10040856 – volume: 127 start-page: 1762 issue: 7 year: 2007 end-page: 1767 ident: CR43 article-title: Regulation of MMP-2 gene transcription in dermal wounds publication-title: J Invest Dermatol doi: 10.1038/sj.jid.5700765 – volume: 2017 start-page: 5192924 year: 2017 ident: CR13 article-title: Effect of topically administered chitosan-N-acetylcysteine on corneal wound healing in a rabbit model publication-title: J Ophthalmol doi: 10.1155/2017/5192924 – volume: 2020 start-page: 1 year: 2020 ident: CR32 article-title: N-Acetyl-cysteine and mechanisms involved in resolution of chronic wound biofilm publication-title: J Diabetes Res – ident: CR23 – volume: 148 start-page: 354 year: 2016 end-page: 361 ident: CR20 article-title: Polyelectrolyte complex nanoparticles from cationised gelatin and sodium alginate for curcumin delivery publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2016.04.073 – volume: 31 start-page: 2855 issue: 7 year: 2023 ident: CR9 article-title: Production of polymer hydrogel composites and their applications publication-title: J Polym Environ doi: 10.1007/s10924-023-02796-z – volume: 10 start-page: 1349 issue: 1 year: 2020 ident: CR3 article-title: Apelin/APJ signaling suppresses the pressure ulcer formation in cutaneous ischemia-reperfusion injury mouse model publication-title: Sci Rep doi: 10.1038/s41598-020-58452-2 – volume: 18 start-page: 130 issue: 71 year: 2019 end-page: 144 ident: CR16 article-title: Study the effect of silymarin and vitamin c in skin aging induced by UVB rays on the mice skin redox system publication-title: J Med Plants – volume: 25 start-page: 19 issue: 1 year: 2007 end-page: 25 ident: CR33 article-title: Impaired wound healing publication-title: Clin Dermatol doi: 10.1016/j.clindermatol.2006.12.005 – volume: 13 start-page: 2959 issue: 17 year: 2021 ident: CR11 article-title: Gelatin-based hybrid scaffolds: promising wound dressings publication-title: Polymers doi: 10.3390/polym13172959 – volume: 83 start-page: 4167 issue: 12 year: 1986 end-page: 4171 ident: CR35 article-title: Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.12.4167 – volume: 2 start-page: 215 issue: 5 year: 2013 end-page: 224 ident: CR36 article-title: Critical role of transforming growth factor beta in different phases of wound healing publication-title: Adv Wound Care (New Rochelle) doi: 10.1089/wound.2012.0406 – volume: 10 start-page: 1013 issue: 7 year: 2021 ident: CR5 article-title: Reactive oxygen species and pressure ulcer formation after traumatic injury to spinal cord and brain publication-title: Antioxidants doi: 10.3390/antiox10071013 – volume: 2 start-page: 329 issue: 2 year: 2007 end-page: 333 ident: CR15 article-title: In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro publication-title: Nat Protoc doi: 10.1038/nprot.2007.30 – volume: 26 start-page: 119 issue: 2 year: 2017 end-page: 124 ident: CR31 article-title: Molecular finds of pressure ulcer: a bioinformatics approach in pressure ulcer publication-title: J Tissue Viability doi: 10.1016/j.jtv.2017.01.002 – volume: 30 start-page: 1499 issue: 12 year: 2015 end-page: 1512 ident: CR25 article-title: Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing publication-title: Histol Histopathol – volume: 164 start-page: 963 year: 2020 end-page: 975 ident: CR12 article-title: Carboxymethyl cellulose-based materials for infection control and wound healing: a review publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.07.160 – volume: 203 start-page: 327 issue: 2 year: 2013 end-page: 343 ident: CR26 article-title: FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress publication-title: J Cell Biol doi: 10.1083/jcb.201305074 – volume: 269 start-page: 209 issue: 1–2 year: 2005 end-page: 216 ident: CR41 article-title: Interaction of keratinocytes and fibroblasts modulates the expression of matrix metalloproteinases-2 and -9 and their inhibitors publication-title: Mol Cell Biochem doi: 10.1007/s11010-005-3178-x – volume: 8 start-page: rbab003 issue: 2 year: 2021 ident: CR14 article-title: Antioxidant biocompatible composite collagen dressing for diabetic wound healing in rat model publication-title: Regen Biomater doi: 10.1093/rb/rbab003 – volume: 15 start-page: 2149 issue: 9 year: 2023 ident: CR10 article-title: Structures, properties, and bioengineering applications of alginates and hyaluronic acid publication-title: Polymers doi: 10.3390/polym15092149 – volume: 175 start-page: 533 issue: 2 year: 2009 end-page: 546 ident: CR40 article-title: MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing publication-title: Am J Pathol doi: 10.2353/ajpath.2009.081080 – volume: 21 start-page: 330 issue: 1 year: 2023 ident: CR18 article-title: Thermosensitive black phosphorus hydrogel loaded with silver sulfadiazine promotes skin wound healing publication-title: J Nanobiotechnol doi: 10.1186/s12951-023-02054-3 – volume: 22 start-page: e163 issue: 11 year: 2020 ident: CR47 article-title: Effects of N-acetyl cysteine on the expression of matrix metalloproteinases 2 and 9 in the lung tissue of rats exposed to cadmium publication-title: Iran Red Crescent Med J – volume: 211 start-page: 19 issue: 1 year: 2007 end-page: 26 ident: CR34 article-title: Regulation of matrix metalloproteinase gene expression publication-title: J Cell Physiol doi: 10.1002/jcp.20948 – volume: 9 start-page: 306 issue: 2 year: 2020 ident: CR37 article-title: Role of TGF-β in skin chronic wounds: a keratinocyte perspective publication-title: Cells doi: 10.3390/cells9020306 – volume: 8 start-page: 127 issue: 2 year: 2022 ident: CR22 article-title: Functional hydrogels for treatment of chronic wounds publication-title: Gels doi: 10.3390/gels8020127 – volume: 10 start-page: 967 issue: 6 year: 2021 ident: CR29 article-title: N-acetylcysteine (NAC): impacts on human health publication-title: Antioxidants doi: 10.3390/antiox10060967 – volume: 214 start-page: 47 issue: 1 year: 2008 end-page: 55 ident: CR44 article-title: Hypoxia induces epidermal keratinocyte matrix metalloproteinase-9 secretion via the protein kinase C pathway publication-title: J Cell Physiol doi: 10.1002/jcp.21160 – ident: 378_CR23 doi: 10.1016/B978-0-323-52727-9.00016-9 – volume: 10 start-page: 856 issue: 4 year: 2022 ident: 378_CR27 publication-title: Biomedicines doi: 10.3390/biomedicines10040856 – volume: 49 start-page: 275 issue: 2 year: 2022 ident: 378_CR38 publication-title: Arch Plast Surg doi: 10.1055/s-0042-1744427 – volume: 45 start-page: 244 issue: 2 year: 2012 ident: 378_CR2 publication-title: Indian J Plast Surg doi: 10.4103/0970-0358.101287 – volume: 8 start-page: rbab003 issue: 2 year: 2021 ident: 378_CR14 publication-title: Regen Biomater doi: 10.1093/rb/rbab003 – volume: 15 start-page: 7563 issue: 5 year: 2014 ident: 378_CR6 publication-title: Int J Mol Sci doi: 10.3390/ijms15057563 – volume: 8 start-page: 127 issue: 2 year: 2022 ident: 378_CR22 publication-title: Gels doi: 10.3390/gels8020127 – volume: 9 start-page: 306 issue: 2 year: 2020 ident: 378_CR37 publication-title: Cells doi: 10.3390/cells9020306 – volume: 13 start-page: 2959 issue: 17 year: 2021 ident: 378_CR11 publication-title: Polymers doi: 10.3390/polym13172959 – volume: 148 start-page: 354 year: 2016 ident: 378_CR20 publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2016.04.073 – volume: 2020 start-page: 1 year: 2020 ident: 378_CR32 publication-title: J Diabetes Res – volume: 351 start-page: 255 issue: 2 year: 2013 ident: 378_CR42 publication-title: Cell Tissue Res doi: 10.1007/s00441-012-1410-z – volume: 46 start-page: 194 issue: 2 year: 2023 ident: 378_CR7 publication-title: J Spinal Cord Med doi: 10.1080/10790268.2021.1916155 – volume: 2 start-page: 329 issue: 2 year: 2007 ident: 378_CR15 publication-title: Nat Protoc doi: 10.1038/nprot.2007.30 – volume: 127 start-page: 1762 issue: 7 year: 2007 ident: 378_CR43 publication-title: J Invest Dermatol doi: 10.1038/sj.jid.5700765 – volume: 26 start-page: 1138 issue: 8 year: 2012 ident: 378_CR45 publication-title: Eye doi: 10.1038/eye.2012.135 – volume: 22 start-page: 398 issue: 1 year: 2022 ident: 378_CR24 publication-title: BMC Oral Health doi: 10.1186/s12903-022-02433-6 – volume: 203 start-page: 327 issue: 2 year: 2013 ident: 378_CR26 publication-title: J Cell Biol doi: 10.1083/jcb.201305074 – volume: 10 start-page: 1349 issue: 1 year: 2020 ident: 378_CR3 publication-title: Sci Rep doi: 10.1038/s41598-020-58452-2 – volume: 175 start-page: 533 issue: 2 year: 2009 ident: 378_CR40 publication-title: Am J Pathol doi: 10.2353/ajpath.2009.081080 – volume: 10 start-page: 967 issue: 6 year: 2021 ident: 378_CR29 publication-title: Antioxidants doi: 10.3390/antiox10060967 – volume: 269 start-page: 209 issue: 1–2 year: 2005 ident: 378_CR41 publication-title: Mol Cell Biochem doi: 10.1007/s11010-005-3178-x – volume: 18 start-page: 130 issue: 71 year: 2019 ident: 378_CR16 publication-title: J Med Plants – volume: 25 start-page: 19 issue: 1 year: 2007 ident: 378_CR33 publication-title: Clin Dermatol doi: 10.1016/j.clindermatol.2006.12.005 – volume: 138 start-page: 50225 issue: 16 year: 2021 ident: 378_CR8 publication-title: J Appl Polym Sci doi: 10.1002/app.50225 – volume: 26 start-page: 119 issue: 2 year: 2017 ident: 378_CR31 publication-title: J Tissue Viability doi: 10.1016/j.jtv.2017.01.002 – volume: 178 start-page: 41 year: 2021 ident: 378_CR19 publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2021.02.133 – volume: 14 start-page: 89 issue: 1 year: 2017 ident: 378_CR28 publication-title: Int Wound J doi: 10.1111/iwj.12557 – volume: 83 start-page: 4167 issue: 12 year: 1986 ident: 378_CR35 publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.83.12.4167 – volume: 211 start-page: 19 issue: 1 year: 2007 ident: 378_CR34 publication-title: J Cell Physiol doi: 10.1002/jcp.20948 – volume: 42 start-page: 854 issue: 11 year: 2012 ident: 378_CR39 publication-title: Insect Biochem Mol Biol doi: 10.1016/j.ibmb.2012.08.001 – volume: 21 start-page: 330 issue: 1 year: 2023 ident: 378_CR18 publication-title: J Nanobiotechnol doi: 10.1186/s12951-023-02054-3 – volume: 60 start-page: 695 issue: 7 year: 2011 ident: 378_CR30 publication-title: Inflamm Res doi: 10.1007/s00011-011-0323-8 – volume: 2 start-page: 215 issue: 5 year: 2013 ident: 378_CR36 publication-title: Adv Wound Care (New Rochelle) doi: 10.1089/wound.2012.0406 – volume: 15 start-page: 1349 year: 2020 ident: 378_CR4 publication-title: Int J Nanomed doi: 10.2147/IJN.S232190 – volume: 22 start-page: e163 issue: 11 year: 2020 ident: 378_CR47 publication-title: Iran Red Crescent Med J – volume: 19 start-page: 1338 issue: 3 year: 2022 ident: 378_CR1 publication-title: Int J Environ Res Public Health doi: 10.3390/ijerph19031338 – volume: 214 start-page: 47 issue: 1 year: 2008 ident: 378_CR44 publication-title: J Cell Physiol doi: 10.1002/jcp.21160 – volume: 164 start-page: 963 year: 2020 ident: 378_CR12 publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.07.160 – volume: 10 start-page: 1013 issue: 7 year: 2021 ident: 378_CR5 publication-title: Antioxidants doi: 10.3390/antiox10071013 – volume: 17 start-page: 221 issue: 4 year: 2004 ident: 378_CR17 publication-title: J Invest Surg doi: 10.1080/08941930490472046 – volume: 31 start-page: 2855 issue: 7 year: 2023 ident: 378_CR9 publication-title: J Polym Environ doi: 10.1007/s10924-023-02796-z – volume: 43 start-page: 571 issue: 6 year: 2018 ident: 378_CR46 publication-title: Turk J Biochem doi: 10.1515/tjb-2017-0046 – volume: 13 start-page: 444 issue: 3 year: 2023 ident: 378_CR21 publication-title: Biomolecules doi: 10.3390/biom13030444 – volume: 30 start-page: 1499 issue: 12 year: 2015 ident: 378_CR25 publication-title: Histol Histopathol – volume: 15 start-page: 2149 issue: 9 year: 2023 ident: 378_CR10 publication-title: Polymers doi: 10.3390/polym15092149 – volume: 2017 start-page: 5192924 year: 2017 ident: 378_CR13 publication-title: J Ophthalmol doi: 10.1155/2017/5192924 |
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| Title | Enhancing pressure ulcer healing and tissue regeneration by using N-acetyl-cysteine loaded carboxymethyl cellulose/gelatin/sodium alginate hydrogel |
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