Existing and Evolving Landscape of Medulloblastoma: Towards Optimization and Personalization

Advances in diagnostic imaging, pathology, and molecular biology coupled with improvements in neurosurgical approaches, radiotherapeutic techniques, and systemic therapies over the last two decades have vastly improved survival outcomes for medulloblastoma, the most common childhood malignant tumor...

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Vydáno v:Diagnostics (Basel) Ročník 14; číslo 6; s. 598
Hlavní autoři: Gupta, Tejpal, Chatterjee, Abhishek
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 12.03.2024
MDPI
Témata:
Brain tumors
Chemotherapy
Clinical outcomes
Clinical trials
DNA methylation
Dosimetry
Immunotherapy
Medulloblastoma
Molecular biology
n/a
Oncology
Optimization
Patients
Pediatrics
Quality of life
Radiation therapy
Radiomics
Toxicity
ISSN:2075-4418, 2075-4418
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Abstract Advances in diagnostic imaging, pathology, and molecular biology coupled with improvements in neurosurgical approaches, radiotherapeutic techniques, and systemic therapies over the last two decades have vastly improved survival outcomes for medulloblastoma, the most common childhood malignant tumor [...]
AbstractList Aggressive multi-modal management cures a substantial proportion of patients with medulloblastoma; however, such therapies are associated with a significant burden of dose-dependent treatment-related toxicities and resultant chronic health conditions that have a detrimental impact on health-related quality of life, including long-term survivorship [8,9]. [...]Mani et al. (contributor 6) report a single-institution audit of clinical outcomes in a molecularly characterized cohort of WNT-subgroup medulloblastoma (n = 67), confirming excellent long-term survival with adequate and appropriate upfront treatment using post-operative adjuvant radio(chemo)therapy. [...]our fundamental understanding of medulloblastoma biology has vastly improved over time, leading to continued refinements in risk stratification and prognostication. In parallel, aggressive multi-modal therapy cures a substantial proportion of children with medulloblastoma; however, these long-term survivors experience various late effects of treatment affecting their quality of life.
Advances in diagnostic imaging, pathology, and molecular biology coupled with improvements in neurosurgical approaches, radiotherapeutic techniques, and systemic therapies over the last two decades have vastly improved survival outcomes for medulloblastoma, the most common childhood malignant tumor [...]
Advances in diagnostic imaging, pathology, and molecular biology coupled with improvements in neurosurgical approaches, radiotherapeutic techniques, and systemic therapies over the last two decades have vastly improved survival outcomes for medulloblastoma, the most common childhood malignant tumor [...].Advances in diagnostic imaging, pathology, and molecular biology coupled with improvements in neurosurgical approaches, radiotherapeutic techniques, and systemic therapies over the last two decades have vastly improved survival outcomes for medulloblastoma, the most common childhood malignant tumor [...].
Audience Academic
Author Chatterjee, Abhishek
Gupta, Tejpal
AuthorAffiliation Department of Radiation Oncology, ACTREC/TMH, Tata Memorial Centre, HBNI, Kharghar, Navi Mumbai 410210, India
AuthorAffiliation_xml – name: Department of Radiation Oncology, ACTREC/TMH, Tata Memorial Centre, HBNI, Kharghar, Navi Mumbai 410210, India
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  surname: Chatterjee
  fullname: Chatterjee, Abhishek
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38535019$$D View this record in MEDLINE/PubMed
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SubjectTerms Brain tumors
Chemotherapy
Clinical outcomes
Clinical trials
DNA methylation
Dosimetry
Immunotherapy
Medulloblastoma
Molecular biology
n/a
Oncology
Optimization
Patients
Pediatrics
Quality of life
Radiation therapy
Radiomics
Toxicity
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