Glutamine sensing licenses cholesterol synthesis

The mevalonate pathway produces essential lipid metabolites such as cholesterol. Although this pathway is negatively regulated by metabolic intermediates, little is known of the metabolites that positively regulate its activity. We found that the amino acid glutamine is required to activate the meva...

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Bibliographic Details
Published in:	The EMBO journal Vol. 43; no. 23; pp. 5837 - 5856
Main Authors:	Garcia, Bruna Martins, Melchinger, Philipp, Medeiros, Tania, Hendrix, Sebastian, Prabhu, Kavan, Corrado, Mauro, Kingma, Jenina, Gorbatenko, Andrej, Deshwal, Soni, Veronese, Matteo, Scorrano, Luca, Pearce, Erika, Giavalisco, Patrick, Zelcer, Noam, Pernas, Lena
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 02.12.2024
Subjects:	Animals Biomedical and Life Sciences Cholesterol - biosynthesis Cholesterol - metabolism EMBO20 EMBO21 Endoplasmic Reticulum - metabolism Glutamine - metabolism Golgi Apparatus - metabolism Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mevalonic Acid - metabolism Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism SREBP2 MFN2 Nutrient Sensing HMGCR Cholesterol
ISSN:	1460-2075, 0261-4189, 1460-2075
Online Access:	Get full text
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