LRRK2 links genetic and sporadic Parkinson's disease

The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families, mutations in LRRK2 can cause PD with age-dependent but variable penetrance and genome-wide association studies have...

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Vydané v:	Biochemical Society transactions Ročník 47; číslo 2; s. 651
Hlavní autori:	Kluss, Jillian H, Mamais, Adamantios, Cookson, Mark R
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 30.04.2019
Predmet:	Animals Genome-Wide Association Study - methods Humans Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 - metabolism Mutation - genetics Parkinson Disease - enzymology Parkinson Disease - genetics Protein Serine-Threonine Kinases - genetics leucine-rich repeat kinase genome-wide association studies Parkinson's disease
ISSN:	1470-8752, 1470-8752
On-line prístup:	Zistit podrobnosti o prístupe
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