Mind the gaps: functional networks disrupted by white matter hyperintensities are associated with greater falls risk

•Lesion network mapping identifies functional networks associated with falls risk•WMH-related disruption to the DAN is associated with greater falls risk•WMH-related disruption to the SMN and VAN are associated with foam sway•Physical activity moderates the association between the DAN and falls risk...

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Bibliographic Details
Published in:	Neurobiology of aging Vol. 109; pp. 166 - 175
Main Authors:	Crockett, Rachel A., Hsu, Chun Liang, Dao, Elizabeth, Tam, Roger, Alkeridy, Walid, Eng, Janice J., Handy, Todd C., Liu-Ambrose, Teresa
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.01.2022
Subjects:	Accidental Falls Aged Aged, 80 and over Attention - physiology Cerebral small vessel disease Exercise - physiology Falls risk Female Functional connectivity Humans Male Middle Aged Nerve Net - pathology Nerve Net - physiopathology Physical activity Postural sway Risk Sensorimotor Cortex - physiology Sensorimotor Cortex - physiopathology Walking Speed White Matter - pathology White Matter - physiopathology White matter hyperintensities Functional connectivity White matter hyperintensities Physical activity Postural sway Cerebral small vessel disease Falls risk
ISSN:	0197-4580, 1558-1497, 1558-1497
Online Access:	Get full text
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