Mind the gaps: functional networks disrupted by white matter hyperintensities are associated with greater falls risk

•Lesion network mapping identifies functional networks associated with falls risk•WMH-related disruption to the DAN is associated with greater falls risk•WMH-related disruption to the SMN and VAN are associated with foam sway•Physical activity moderates the association between the DAN and falls risk...

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Vydané v:	Neurobiology of aging Ročník 109; s. 166 - 175
Hlavní autori:	Crockett, Rachel A., Hsu, Chun Liang, Dao, Elizabeth, Tam, Roger, Alkeridy, Walid, Eng, Janice J., Handy, Todd C., Liu-Ambrose, Teresa
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Elsevier Inc 01.01.2022
Predmet:	Accidental Falls Aged Aged, 80 and over Attention - physiology Cerebral small vessel disease Exercise - physiology Falls risk Female Functional connectivity Humans Male Middle Aged Nerve Net - pathology Nerve Net - physiopathology Physical activity Postural sway Risk Sensorimotor Cortex - physiology Sensorimotor Cortex - physiopathology Walking Speed White Matter - pathology White Matter - physiopathology White matter hyperintensities Functional connectivity White matter hyperintensities Physical activity Postural sway Cerebral small vessel disease Falls risk
ISSN:	0197-4580, 1558-1497, 1558-1497
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Shrnutí:	•Lesion network mapping identifies functional networks associated with falls risk•WMH-related disruption to the DAN is associated with greater falls risk•WMH-related disruption to the SMN and VAN are associated with foam sway•Physical activity moderates the association between the DAN and falls risk White matter hyperintensities (WMH) are associated with greater falls risk and slow gait speed. Whether these deficits are caused by the disruption of large-scale functional networks remains inconclusive. Further, physical activity moderates the association between WMHs and falls, but whether this extends to the disruption of functional networks remains unknown. One hundred and sixty-four adults (>55 years old) were included in this study. Using lesion network mapping, we identified significant correlations between the percentage of WMH-related disruption of the dorsal attention network and Physiological Profile Assessment (PPA) score (r = 0.24, p < 0.01); and between disruption of both the sensorimotor (r = 0.23, p < 0.01) and ventral attention networks (r = 0.21, p = 0.01) with foam sway. There were no significant associations with floor sway or gait speed. Physical activity moderated the association between the dorsal attention network and PPA score (p = 0.045). Thus, future research should investigate whether physical activity should be recommended in the clinical management of older adults with cerebral small vessel disease.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0197-4580 1558-1497 1558-1497
DOI:	10.1016/j.neurobiolaging.2021.09.023