Topoisomerases as anticancer targets

Many cancer type-specific anticancer agents have been developed and significant advances have been made toward precision medicine in cancer treatment. However, traditional or nonspecific anticancer drugs are still important for the treatment of many cancer patients whose cancers either do not respon...

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Veröffentlicht in:	Biochemical journal Jg. 475; H. 2; S. 373
Hauptverfasser:	Delgado, Justine L, Hsieh, Chao-Ming, Chan, Nei-Li, Hiasa, Hiroshi
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 23.01.2018
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Catalytic Domain DNA - chemistry DNA - genetics DNA - metabolism DNA Breaks, Double-Stranded DNA Topoisomerases, Type II - chemistry DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA, Neoplasm - chemistry DNA, Neoplasm - genetics DNA, Neoplasm - metabolism Drug Design Gene Expression Humans Molecular Docking Simulation Molecular Targeted Therapy - methods Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - genetics Neoplasms - pathology Protein Structure, Secondary Structure-Activity Relationship Topoisomerase Inhibitors - chemistry Topoisomerase Inhibitors - pharmacology topoisomerase II topoisomerase inhibitors chemotherapy topoisomerase poisoning anticancer agents topoisomerase I
ISSN:	1470-8728, 1470-8728
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