Relation of Lymphangiogenic Factor Vascular Endothelial Growth Factor-D to Elevated Pulmonary Artery Wedge Pressure

Lymphatic flow is augmented in states of chronic heart failure (cHF). However, the biological mechanism driving increased lymphatic flow capacity (lymphangiogenesis) in cHF is unknown. Recent studies have indicated that vascular endothelial growth factors (VEGF-A, -C, and -D) are involved in lymphan...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The American journal of cardiology Ročník 124; číslo 5; s. 756 - 762
Hlavní autoři: Houston, Brian A., Tedford, Ryan J., Baxley, Renee L., Sykes, Brandon, Powers, Eric R., Nielsen, Christopher D., Steinberg, Daniel H., Maran, Anbukarasi, Fernandes, Valerian L.C., Todoran, Thomas, Jones, Jeffrey A., Zile, Michael R.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.09.2019
Elsevier Limited
Témata:
Adult
Aged
Biomarkers - metabolism
Brain natriuretic peptide
Cardiac Catheterization - methods
Cardiac output
Cardiomyopathy
Cardiovascular disease
Catheterization
Chronic Disease
Congestive heart failure
Consent
Disease Progression
Dyspnea
Female
Growth factors
Heart
Heart failure
Heart Failure - blood
Heart Failure - diagnosis
Hemodynamics
Hemodynamics - physiology
Hospitals, University
Humans
Hypertension
Hypertension, Pulmonary - physiopathology
Lymphangiogenesis - physiology
Male
Middle Aged
Peptides
Pressure
Prognosis
Pulmonary arteries
Pulmonary artery
Pulmonary Wedge Pressure - physiology
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Stroke Volume - physiology
Vascular endothelial growth factor
Vascular Endothelial Growth Factor D - metabolism
Veins & arteries
Wedges
ISSN:0002-9149, 1879-1913, 1879-1913
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Lymphatic flow is augmented in states of chronic heart failure (cHF). However, the biological mechanism driving increased lymphatic flow capacity (lymphangiogenesis) in cHF is unknown. Recent studies have indicated that vascular endothelial growth factors (VEGF-A, -C, and -D) are involved in lymphangiogenesis. This study examined the association between VEGF-A, -C, and -D levels, invasively measured hemodynamics, and heart failure symptoms. Subjects who underwent clinically indicated right heart catheterization at Medical University of South Carolina between 12/2016 and 7/2018 were eligible for inclusion. These subjects underwent clinical assessment of cHF severity (including 6MWT and KCCQ), hemodynamic assessment with right heart catheterization, laboratory studies including B-type natriuretic peptide, and concomitant measurement of VEGF-A, -C, and -D. Fifty-six patients were included for analysis. Subjects with elevated pulmonary artery wedge pressure (PAWP) had significantly higher VEGF-D levels (263 ± 415 pg/ml vs 65 ± 101 pg/ml; p = 0.02). PAWP was not associated with VEGF-A or VEGF-C levels. When stratified by VEGF-D, subjects with elevated VEGF-D had clinical and hemodynamic characteristics associated with worse HF severity (lower ejection fraction, higher b-type natriuretic peptide, higher PAWP, lower cardiac output), but were not more symptomatic by Kansas City Cardiomyopathy Questionnaire scores and had similar 6-minute walk test distance compared with subjects with lower VEGF-D. Subjects with an elevated VEGF-D were more likely to have a diagnosis of heart failure for >3 years. In conclusion, VEGF-D is associated with elevated PAWP in cHF, and elevated VEGF-D may mitigate cHF symptoms.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2019.05.056