Cyclin D1 ( CCND1) A870G gene polymorphism modulates smoking-induced lung cancer risk and response to platinum-based chemotherapy in non-small cell lung cancer (NSCLC) patients

The cyclin D1 ( CCND1) A870G gene polymorphism is linked to the outcome in patients with resectable non-small cell lung cancer (NSCLC). Here, we investigated the impact of this polymorphism on smoking-induced cancer risk and clinical outcome in patients with NSCLC stages I–IV. CCND1 A870G genotype w...

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Bibliographic Details
Published in:	Lung cancer (Amsterdam, Netherlands) Vol. 51; no. 3; pp. 303 - 311
Main Authors:	Gautschi, Oliver, Hugli, Barbara, Ziegler, Annemarie, Bigosch, Colette, Bowers, Naomi L., Ratschiller, Daniel, Jermann, Monika, Stahel, Rolf A., Heighway, Jim, Betticher, Daniel C.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 01.03.2006 Elsevier Science
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Case-Control Studies Chemotherapy Cisplatin - administration & dosage Cyclin D1 Cyclin D1 - genetics Female Gene polymorphism Genetic Predisposition to Disease Genotype Humans Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - genetics Male Medical sciences Middle Aged Neoplasm Staging Pneumology Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Predictive factor Smoking Smoking - adverse effects Statistics, Nonparametric Survival Analysis Tobacco, tobacco smoking Toxicology Tumors of the respiratory system and mediastinum Chemotherapy CCND1 NSCLC Lung cancer Cyclin D1 Predictive factor Gene polymorphism PCR RFLP Smoking Human Lung disease Respiratory disease Tobacco smoking Risk Malignant tumor non-small cell lung carcinoma Cisplatin Treatment Gene Platinum Risk factor Carboplatin Bronchus disease Non small cell carcinoma Polymorphism
ISSN:	0169-5002, 1872-8332
Online Access:	Get full text
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