Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors

Haploinsufficiency of EFTUD2 (Elongation Factor Tu GTP Binding Domain Containing 2) is linked to human mandibulofacial dysostosis, Guion-Almeida type (MFDGA), but the underlying cellular and molecular mechanisms remain to be addressed. We report here the isolation, cloning and functional analysis of...

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Vydané v:	Nucleic acids research Ročník 45; číslo 6; s. 3422 - 3436
Hlavní autori:	Lei, Lei, Yan, Shou-Yu, Yang, Ran, Chen, Jia-Yu, Li, Yumei, Bu, Ye, Chang, Nannan, Zhou, Qinchao, Zhu, Xiaojun, Li, Chuan-Yun, Xiong, Jing-Wei
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England Oxford University Press 07.04.2017
Predmet:	Animals Apoptosis Brain - abnormalities Cloning, Molecular Exons Introns Mutation Neural Stem Cells - cytology Neurogenesis - genetics Neurons - cytology Nonsense Mediated mRNA Decay Peptide Elongation Factors - genetics RNA RNA Splicing RNA Splicing Factors - genetics Spinal Cord - abnormalities Transcriptome Tumor Suppressor Protein p53 - metabolism Zebrafish - genetics Zebrafish - growth & development Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
ISSN:	0305-1048, 1362-4962
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