Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior

Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Growing evidence reveals that the pathophysiology of these disorders might derive from aberrations of normal neurodevelopmental changes in...

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Veröffentlicht in:	The Journal of neuroscience Jg. 35; H. 41; S. 13975 - 13988
Hauptverfasser:	Schneider, Miriam, Kasanetz, Fernando, Lynch, Diane L, Friemel, Chris M, Lassalle, Olivier, Hurst, Dow P, Steindel, Frauke, Monory, Krisztina, Schäfer, Carola, Miederer, Isabelle, Leweke, F Markus, Schreckenberger, Mathias, Lutz, Beat, Reggio, Patricia H, Manzoni, Olivier J, Spanagel, Rainer
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.10.2015
Schlagworte:	Adolescent Adolescent Behavior - physiology Age Factors Animals Behavior, Animal - drug effects Behavior, Animal - physiology Brain - diagnostic imaging Brain - drug effects Brain - growth & development Cannabinoid Receptor Antagonists - pharmacology Cocaine - administration & dosage Corpus Striatum - cytology Endocannabinoids - metabolism Endocannabinoids - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Guanosine 5'-O-(3-Thiotriphosphate) - pharmacokinetics Humans In Vitro Techniques Male Maze Learning - drug effects Maze Learning - physiology Models, Animal Mutation - genetics Radionuclide Imaging Rats Rats, Inbred F344 Rats, Transgenic Receptor, Cannabinoid, CB1 - genetics Receptor, Cannabinoid, CB1 - metabolism Risk-Taking Social Behavior Sulfur Isotopes - pharmacokinetics adolescence endocannabinoids reward processing ENU mutagenesis CB1 receptor risk seeking
ISSN:	1529-2401
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