Immune-Active Microenvironment in Small Cell Carcinoma of the Ovary, Hypercalcemic Type: Rationale for Immune Checkpoint Blockade

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT), is a highly aggressive monogenic cancer driven by SMARCA4 mutations. Here, we report responses to anti-PD1 immunotherapy in four patients and characterize the immune landscape of SCCOHT tumors using quantitative immunofluorescence and g...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute Jg. 110; H. 7; S. 787
Hauptverfasser:	Jelinic, Petar, Ricca, Jacob, Van Oudenhove, Elke, Olvera, Narciso, Merghoub, Taha, Levine, Douglas A, Zamarin, Dmitriy
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2018
Schlagworte:	Adolescent Adult Antibodies, Monoclonal - therapeutic use B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology Carcinoma, Small Cell - drug therapy Carcinoma, Small Cell - genetics Carcinoma, Small Cell - immunology Carcinoma, Small Cell - pathology Cell Cycle Checkpoints - drug effects Cell Cycle Checkpoints - immunology DNA Helicases - genetics Female Humans Hypercalcemia - complications Hypercalcemia - genetics Hypercalcemia - immunology Hypercalcemia - pathology Immunotherapy - methods Mutation Nuclear Proteins - genetics Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - immunology Ovarian Neoplasms - pathology Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Rationalization Transcription Factors - genetics Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Young Adult
ISSN:	1460-2105, 1460-2105
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