A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study

COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration, an...

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Published in:eLife Vol. 9
Main Authors: Linssen, Joachim, Ermens, Anthony, Berrevoets, Marvin, Seghezzi, Michela, Previtali, Giulia, van der Sar-van der Brugge, Simone, Russcher, Henk, Verbon, Annelies, Gillis, Judith, Riedl, Jürgen, de Jongh, Eva, Saker, Jarob, Münster, Marion, Munnix, Imke CA, Dofferhof, Anthonius, Scharnhorst, Volkher, Ammerlaan, Heidi, Deiteren, Kathleen, Bakker, Stephan JL, Van Pelt, Lucas Joost, Kluiters-de Hingh, Yvette, Leers, Mathie PG, van der Ven, Andre J
Format: Journal Article
Language:English
Published: England eLife Sciences Publications, Ltd 26.11.2020
eLife Sciences Publications Ltd
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Blood Cell Count - instrumentation
Blood Cell Count - methods
Blood Cell Count - statistics & numerical data
Cohort Studies
complete blood count
COVID-19
COVID-19 - blood
COVID-19 - epidemiology
COVID-19 - virology
Europe
Female
haemocytometry
Hospitalization - statistics & numerical data
Hospitals
Humans
intensive care
Male
Medicine
Middle Aged
Pandemics
Prognosis
prognostic score
Retrospective Studies
SARS-CoV-2 - physiology
Young Adult
Europe
COVID-19
prognostic score
intensive care
medicine
haemocytometry
human
complete blood count
ISSN:2050-084X, 2050-084X
Online Access:Get full text
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Summary:COVID-19 induces haemocytometric changes. Complete blood count changes, including new cell activation parameters, from 982 confirmed COVID-19 adult patients from 11 European hospitals were retrospectively analysed for distinctive patterns based on age, gender, clinical severity, symptom duration, and hospital days. The observed haemocytometric patterns formed the basis to develop a multi-haemocytometric-parameter prognostic score to predict, during the first three days after presentation, which patients will recover without ventilation or deteriorate within a two-week timeframe, needing intensive care or with fatal outcome. The prognostic score, with ROC curve AUC at baseline of 0.753 (95% CI 0.723–0.781) increasing to 0.875 (95% CI 0.806–0.926) on day 3, was superior to any individual parameter at distinguishing between clinical severity. Findings were confirmed in a validation cohort. Aim is that the score and haemocytometry results are simultaneously provided by analyser software, enabling wide applicability of the score as haemocytometry is commonly requested in COVID-19 patients.
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ISSN:2050-084X
2050-084X
DOI:10.7554/eLife.63195