Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction

Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk. Valvular aortic ste...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 371; no. 8; pp. 744 - 756
Main Authors: Otto, Catherine M, Prendergast, Bernard
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 21.08.2014
Subjects:
Age
Aortic Valve Stenosis - classification
Aortic Valve Stenosis - physiopathology
Aortic Valve Stenosis - surgery
Biological and medical sciences
Calcification
Cardiology
Cardiovascular disease
Coronary vessels
Disease Progression
General aspects
Heart
Heart surgery
Heart Valve Prosthesis Implantation
Humans
Lipoproteins
Medical sciences
Mortality
Risk Factors
Stenosis
Ventricle
Ventricular Function, Left
United States > US
Human
Medicine
Aortic stenosis
Obstruction
Aortic valve
Risk factor
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:Aortic-valve stenosis is a progressive condition; end-stage disease leads to death due to obstruction of left ventricular outflow. Aortic-valve replacement is the only effective therapy. Transcatheter aortic-valve replacement is appropriate in patients at very high surgical risk. Valvular aortic stenosis is a progressive disease in which the end stage is characterized by obstruction of left ventricular outflow, resulting in inadequate cardiac output, decreased exercise capacity, heart failure, and death from cardiovascular causes. The prevalence of aortic stenosis is only about 0.2% among adults between the ages of 50 and 59 years but increases to 9.8% in octogenarians, with an overall prevalence of 2.8% in adults older than 75 years of age. 1 , 2 Although mortality is not increased when aortic stenosis is asymptomatic, the rate of death is more than 50% at 2 years for patients with symptomatic . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMra1313875