Advancing Peptide-Based Vaccines Against Candida: A Comparative Perspective on Liposomal and Synthetic Formulations

The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing...

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Vydané v:Journal of fungi (Basel) Ročník 11; číslo 10; s. 715
Hlavný autor: Xin, Hong
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 02.10.2025
Predmet:
5-Methyltetrahydrofolate-homocysteine S-methyltransferase
Adjuvants
Animal models
Antibodies
Antifungal agents
antifungal immunotherapy
Antigen presentation
Antigens
Candida auris
Cobalt
CoPoP liposomes
Cytokines
Drug dosages
Drug resistance
Fructose
Fungal infections
Immunogenicity
Immunology
Licenses
Lymphocytes
Lymphocytes T
Medical prognosis
Methionine
Multidrug resistance
Pathogens
peptide vaccine
Peptides
SNAP platform
Tropical diseases
Vaccination
Vaccines
Candida auris
antifungal immunotherapy
SNAP platform
CoPoP liposomes
peptide vaccine
ISSN:2309-608X, 2309-608X
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Popis
Shrnutí:The growing threat of multidrug-resistant fungal pathogens, especially Candida auris, has underscored the need for effective antifungal vaccines. This commentary highlights recent advances in peptide-based vaccination using the SNAP (Spontaneous Nanoliposome Antigen Presentation) platform, focusing on the FM-SNAP vaccine, a bivalent liposomal formulation targeting the surface-expressed peptides fructose bisphosphate aldolase (Fba) and methionine synthase (Met6). Compared to earlier constructs such as MP12, FM-SNAP achieves superior immunogenicity and long-lasting protection at lower antigen doses. It elicits balanced Th1/Th2 cytokine responses and demonstrates durable efficacy in both immunocompetent and complement-deficient mouse models. The platform’s compatibility with clinically approved adjuvants (MPLA and QS-21), modular peptide design, and potential for multi-pathogen applications underscores its translational promise. FM-SNAP exemplifies a next-generation vaccine strategy that is both scalable and adaptable for high-risk immunocompromised populations.
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ISSN:2309-608X
2309-608X
DOI:10.3390/jof11100715