Narcolepsy treatment: pharmacological and behavioral strategies in adults and children

Narcolepsy is a disabling, rare, and chronic sleep disorder, currently classified as distinct central nervous system hypersomnia in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Although today a reliable pathogenic hypothesis identifies the cause of NT1 as an autoimmune process destroying hyp...

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Bibliographic Details
Published in:Sleep & breathing Vol. 24; no. 2; pp. 615 - 627
Main Authors: Franceschini, Christian, Pizza, Fabio, Antelmi, Elena, Folli, Maria Claudia, Plazzi, Giuseppe
Format: Journal Article
Language:English
Published: Cham Springer International Publishing 01.06.2020
Springer Nature B.V
Subjects:
Adults
Behavior
Behavior modification
Behavior problems
Birth control
Central nervous system
Childhood
Children
Cure
Dentistry
Disease management
Dopamine
Drug dosages
Drug therapy
Excessive Daytime Sleepiness
FDA approval
Federal regulation
Headaches
Hypersomnia
Hypothalamus
Hypotheses
Insomnia
Internal Medicine
Life course
Medical treatment
Medicine
Medicine & Public Health
Narcolepsy
Nausea
Nervous system
Neurology
Neurology • Review
Neurotrophin 1
Neurotrophin 2
Orexins
Otorhinolaryngology
Patients
Pediatrics
Pneumology/Respiratory System
Psychosocial factors
Psychosocial intervention
Quality of life
Side effects
Sleep
Sleep disorders
Sodium
Substance abuse treatment
Therapy
Treatment methods
Pharmacological treatment
Narcolepsy
Adults
Children
Behavioral treatment
Psychological treatment
ISSN:1520-9512, 1522-1709, 1522-1709
Online Access:Get full text
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Description
Summary:Narcolepsy is a disabling, rare, and chronic sleep disorder, currently classified as distinct central nervous system hypersomnia in narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Although today a reliable pathogenic hypothesis identifies the cause of NT1 as an autoimmune process destroying hypocretin-producing cells, there is no cure for narcolepsy, and the symptomatic pharmacological available treatments are not entirely effective for all symptoms. Behavioral therapies play a synergistic role in the disease treatment. We here review the available therapeutic options for narcolepsy, including symptomatic pharmacological treatments as well as behavioral and psychosocial interventions that could help clinicians improve the quality of life of patients with narcolepsy in adulthood and childhood.
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ISSN:1520-9512
1522-1709
1522-1709
DOI:10.1007/s11325-019-01894-4