ctDNA monitoring using patient-specific sequencing and integration of variant reads

Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detection of ctDNA can be challenging in patients with low-volume or residual disease, where plasma contains very few tumor-derived DNA fragments. We show that sensitivity for ctDNA detection in plasma can be...

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Vydáno v:	Science translational medicine Ročník 12; číslo 548
Hlavní autoři:	Wan, Jonathan C M, Heider, Katrin, Gale, Davina, Murphy, Suzanne, Fisher, Eyal, Mouliere, Florent, Ruiz-Valdepenas, Andrea, Santonja, Angela, Morris, James, Chandrananda, Dineika, Marshall, Andrea, Gill, Andrew B, Chan, Pui Ying, Barker, Emily, Young, Gemma, Cooper, Wendy N, Hudecova, Irena, Marass, Francesco, Mair, Richard, Brindle, Kevin M, Stewart, Grant D, Abraham, Jean E, Caldas, Carlos, Rassl, Doris M, Rintoul, Robert C, Alifrangis, Constantine, Middleton, Mark R, Gallagher, Ferdia A, Parkinson, Christine, Durrani, Amer, McDermott, Ultan, Smith, Christopher G, Massie, Charles, Corrie, Pippa G, Rosenfeld, Nitzan
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 17.06.2020
Témata:	Biomarkers, Tumor Circulating Tumor DNA - genetics DNA, Neoplasm - genetics High-Throughput Nucleotide Sequencing Humans Liquid Biopsy Mutation - genetics
ISSN:	1946-6242, 1946-6242
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