Molecular Recognition of Sialic Acid End Groups by Phenylboronates

A multinuclear NMR study of the interaction between phenylboronic acid (PBA) and sialic acid (Neu5 Ac) has been performed. The latter compound is known to be overexpressed on the cell surface of tumor cells. The results of this investigation suggest that the binding of PBA to sialic acid is pH depen...

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Bibliographic Details
Published in:	Chemistry : a European journal Vol. 11; no. 13; pp. 4010 - 4018
Main Authors:	Djanashvili, Kristina, Frullano, Luca, Peters, Joop A.
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 20.06.2005 WILEY‐VCH Verlag
Subjects:	borates Boronic Acids - chemistry Butyrates - chemistry carbohydrates Esters - chemistry glycoproteins Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy molecular recognition Molecular Structure N-Acetylneuraminic Acid - chemistry sialic acids
ISSN:	0947-6539, 1521-3765
Online Access:	Get full text
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