Molecular Recognition of Sialic Acid End Groups by Phenylboronates

A multinuclear NMR study of the interaction between phenylboronic acid (PBA) and sialic acid (Neu5 Ac) has been performed. The latter compound is known to be overexpressed on the cell surface of tumor cells. The results of this investigation suggest that the binding of PBA to sialic acid is pH depen...

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Veröffentlicht in:	Chemistry : a European journal Jg. 11; H. 13; S. 4010 - 4018
Hauptverfasser:	Djanashvili, Kristina, Frullano, Luca, Peters, Joop A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Weinheim WILEY-VCH Verlag 20.06.2005 WILEY‐VCH Verlag
Schlagworte:	borates Boronic Acids - chemistry Butyrates - chemistry carbohydrates Esters - chemistry glycoproteins Hydrogen-Ion Concentration Magnetic Resonance Spectroscopy molecular recognition Molecular Structure N-Acetylneuraminic Acid - chemistry sialic acids
ISSN:	0947-6539, 1521-3765
Online-Zugang:	Volltext
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