Tumor-mediated immunosuppression and cytokine spreading affects the relation between EMT and PD-L1 status

Epithelial-mesenchymal transition (EMT) and immune resistance mediated by Programmed Death-Ligand 1 (PD-L1) upregulation are established drivers of tumor progression. Their bi-directional crosstalk has been proposed to facilitate tumor immunoevasion, yet the impact of immunosuppression and spatial h...

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Vydané v:	Frontiers in immunology Ročník 14; s. 1219669
Hlavní autori:	Lems, Carlijn M., Burger, Gerhard A., Beltman, Joost B.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Frontiers Media S.A 10.08.2023
Predmet:	cellular Potts model epithelial-mesenchymal transition (EMT) immunoevasion Immunology ordinary differential equations PD-L1
ISSN:	1664-3224, 1664-3224
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