Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (ma...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 359; no. 6382; p. 1403
Main Authors:	Pereira, Ethel R, Kedrin, Dmitriy, Seano, Giorgio, Gautier, Olivia, Meijer, Eelco F J, Jones, Dennis, Chin, Shan-Min, Kitahara, Shuji, Bouta, Echoe M, Chang, Jonathan, Beech, Elizabeth, Jeong, Han-Sin, Carroll, Michael C, Taghian, Alphonse G, Padera, Timothy P
Format:	Journal Article
Language:	English
Published:	United States 23.03.2018
Subjects:	Animals Blood Vessels - pathology Carcinoma, Squamous Cell Cell Line, Tumor Cell Movement Cell Tracking - methods Cytosol - chemistry Female Luminescent Proteins - analysis Lung - pathology Lymph Nodes - pathology Lymphatic Metastasis - pathology Melanoma, Experimental Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Seeding Neoplastic Cells, Circulating
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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