Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice

Lymph node metastases in cancer patients are associated with tumor aggressiveness, poorer prognoses, and the recommendation for systemic therapy. Whether cancer cells in lymph nodes can seed distant metastases has been a subject of considerable debate. We studied mice implanted with cancer cells (ma...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) Jg. 359; H. 6382; S. 1403
Hauptverfasser:	Pereira, Ethel R, Kedrin, Dmitriy, Seano, Giorgio, Gautier, Olivia, Meijer, Eelco F J, Jones, Dennis, Chin, Shan-Min, Kitahara, Shuji, Bouta, Echoe M, Chang, Jonathan, Beech, Elizabeth, Jeong, Han-Sin, Carroll, Michael C, Taghian, Alphonse G, Padera, Timothy P
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 23.03.2018
Schlagworte:	Animals Blood Vessels - pathology Carcinoma, Squamous Cell Cell Line, Tumor Cell Movement Cell Tracking - methods Cytosol - chemistry Female Luminescent Proteins - analysis Lung - pathology Lymph Nodes - pathology Lymphatic Metastasis - pathology Melanoma, Experimental Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasm Seeding Neoplastic Cells, Circulating
ISSN:	1095-9203, 1095-9203
Online-Zugang:	Weitere Angaben
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