Assessment of Paravalvular Leak Severity and Thrombogenic Potential in Transcatheter Bicuspid Aortic Valve Replacements Using Patient-Specific Computational Modeling
Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance,...
Saved in:
| Published in: | Journal of cardiovascular translational research Vol. 15; no. 4; pp. 834 - 844 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
New York
Springer US
01.08.2022
|
| Subjects: | |
| ISSN: | 1937-5387, 1937-5395, 1937-5395 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling, we address some of these complications. The degree and location of post-TAVR PVL was assessed, and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients — using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complications, and compare the performance of different device
s
to achieve better clinical outcomes.
Graphical abstract
Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances. |
|---|---|
| AbstractList | Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling, we address some of these complications. The degree and location of post-TAVR PVL was assessed, and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients - using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complications, and compare the performance of different devices to achieve better clinical outcomes. Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances.Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling, we address some of these complications. The degree and location of post-TAVR PVL was assessed, and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients - using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complications, and compare the performance of different devices to achieve better clinical outcomes. Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances. Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling, we address some of these complications. The degree and location of post-TAVR PVL was assessed, and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients — using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complications, and compare the performance of different device s to achieve better clinical outcomes. Graphical abstract Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances. BAV, the most common congenital valvular abnormality, generate asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling we address some of these complications. The degree and location of post-TAVR PVL was assessed and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients − using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in-silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complicaitons, and compare the performance of different devices to achieve better clinical outcomes. Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that expedite valvular calcification and structural degeneration. Recently adapted for use in BAV patients, TAVR demonstrates promising performance, but post-TAVR complications tend to get exacerbated due to BAV anatomical complexities. Utilizing patient-specific computational modeling, we address some of these complications. The degree and location of post-TAVR PVL was assessed, and the risk of flow-induced thrombogenicity was analyzed in 3 BAV patients - using older generation TAVR devices that were implanted in these patients, and compared them to the performance of the newest generation TAVR devices using in silico patient models. Significant decrease in PVL and thrombogenic potential was observed after implantation of the newest generation device. The current work demonstrates the potential of using simulations in pre-procedural planning to assess post-TAVR complications, and compare the performance of different devices to achieve better clinical outcomes. Patient-specific computational framework to assess post-transcatheter bicuspid aortic valve replacement paravalvular leakage and flow-induced thrombogenic complications and compare device performances. |
| Author | Ghosh, Ram P. Haj-Ali, Rami Hamdan, Ashraf Kovarovic, Brandon J. Bluestein, Danny Bianchi, Matteo Anam, Salwa B. |
| AuthorAffiliation | 3 School of Mechanical Engineering, Tel-Aviv University, Tel-Aviv, Israel 2 Department of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel 1 Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA |
| AuthorAffiliation_xml | – name: 2 Department of Cardiology, Rabin Medical Center, Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel – name: 3 School of Mechanical Engineering, Tel-Aviv University, Tel-Aviv, Israel – name: 1 Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA |
| Author_xml | – sequence: 1 givenname: Salwa B. surname: Anam fullname: Anam, Salwa B. organization: Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University – sequence: 2 givenname: Brandon J. surname: Kovarovic fullname: Kovarovic, Brandon J. organization: Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University – sequence: 3 givenname: Ram P. surname: Ghosh fullname: Ghosh, Ram P. organization: Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University – sequence: 4 givenname: Matteo surname: Bianchi fullname: Bianchi, Matteo organization: Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University – sequence: 5 givenname: Ashraf surname: Hamdan fullname: Hamdan, Ashraf organization: Department of Cardiology, Rabin Medical Center – sequence: 6 givenname: Rami surname: Haj-Ali fullname: Haj-Ali, Rami organization: School of Mechanical Engineering, Faculty of Engineering, Tel-Aviv University – sequence: 7 givenname: Danny orcidid: 0000-0002-4014-2308 surname: Bluestein fullname: Bluestein, Danny email: danny.bluestein@stonybrook.edu organization: Biofluids Research Group, Department of Biomedical Engineering, Stony Brook University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34859367$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kstu1DAUhiNURC_wAiyQl2wCdi52skEaRtykQVR0ytZynJMZF8dObWek9n36nj1l2gpYdOXL-f7_t3zOcXbgvIMse83oO0apeB9ZUfA6pwXLGWUty6-fZUesLUVel2198LhvxGF2HOMFpbygQrzIDsuqqduSi6PsZhEjxDiCS8QP5FQFtVN2N1sVyArUb3IGOwgmXRHlerLeBj92fgPOaHLqE6qMssQ4sg7KRa3SFhIE8tHoOU6mJwsfEqK_0BLIT5is0nCXFcl5NG6DecngMT-bQJsByaUfpznhrXdo_N33YJF7mT0flI3w6n49yc4_f1ovv-arH1--LRerXFcVT3lHO9EMGnhZDZVqqr5XumcDCKZowxteqroZOg690FDrgtaDLinWetFV-CNFeZJ92PtOczdCr_FpQVk5BTOqcCW9MvLfijNbufE72TKObWjR4O29QfCXM8QkRxM1WKsc-DnKglPeFhhaI_rm76zHkIfeINDsAR18jAEGqc3-ZzDaWMmovBsDuR8DifnyzxjIa5QW_0kf3J8UlXtRRNhtIMgLPwdsQ3xKdQu0-sun |
| CitedBy_id | crossref_primary_10_1007_s10439_023_03246_6 crossref_primary_10_1177_02676591241239277 crossref_primary_10_1016_j_clinbiomech_2023_106003 crossref_primary_10_1007_s10439_022_03039_3 crossref_primary_10_1007_s10439_023_03360_5 crossref_primary_10_1007_s10439_023_03419_3 crossref_primary_10_1016_j_cmpb_2024_108314 crossref_primary_10_3390_jcm12144774 crossref_primary_10_1097_MAT_0000000000002459 crossref_primary_10_1161_JAHA_125_041505 crossref_primary_10_1007_s10237_024_01816_8 crossref_primary_10_1098_rsos_230905 crossref_primary_10_3389_fcvm_2023_1136935 crossref_primary_10_1007_s13239_022_00620_8 crossref_primary_10_1016_j_compbiomed_2025_109690 crossref_primary_10_3390_bioengineering10020188 crossref_primary_10_1007_s10237_024_01893_9 crossref_primary_10_1016_j_compbiomed_2025_110558 |
| Cites_doi | 10.1093/ehjci/jex258 10.1016/j.jcin.2019.07.032 10.1155/2012/145202 10.1016/j.jaccas.2019.10.013 10.1016/j.jcin.2018.10.005 10.1136/openhrt-2019-001164 10.1007/s10237-018-1094-8 10.21037/jtd.2020.01.10 10.1016/j.jtcvs.2016.05.023 10.1161/CIRCULATIONAHA.120.048048 10.1016/j.jbiomech.2010.04.020 10.1001/jama.2019.7108 10.1016/j.jcin.2020.03.022 10.1038/s41598-020-66899-6 10.1007/s11517-020-02138-4 10.1016/j.cpcardiol.2005.06.002 10.20517/2574-1209.2018.39 10.1007/s10237-014-0583-7 10.1371/journal.pone.0032463 10.1115/1.4040457 10.1111/aor.12806 10.1161/CIRCULATIONAHA.119.040333 10.1002/jbm.a.34099 10.1016/j.jcin.2016.01.003 10.1136/heart.83.1.81 10.1016/j.jcmg.2015.01.008 10.1001/jama.2019.7525 10.1016/j.jacc.2020.07.005 10.1098/rsif.2019.0893 10.1115/1.4026254 10.1016/s0140-6736(15)60308-7 10.1155/2020/2582938 10.21037/cdt.2019.09.12 10.1007/s10439-020-02571-4 10.1007/s11517-019-02012-y |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021 – notice: 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1007/s12265-021-10191-z |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1937-5395 |
| EndPage | 844 |
| ExternalDocumentID | PMC9160219 34859367 10_1007_s12265_021_10191_z |
| Genre | Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: national institute of biomedical imaging and bioengineering grantid: U01EB026414-01 funderid: http://dx.doi.org/10.13039/100000070 – fundername: NIBIB NIH HHS grantid: U01 EB026414 |
| GroupedDBID | --- -5E -5G -BR -EM -Y2 -~C 06C 06D 0R~ 0VY 1N0 203 29K 29~ 2JN 2JY 2KG 2VQ 2~H 30V 4.4 406 408 409 40D 53G 5GY 5VS 67Z 6NX 875 8TC 8UJ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBXA ABDZT ABECU ABFTV ABHQN ABIPD ABJNI ABJOX ABKCH ABMNI ABMQK ABPLI ABQBU ABSXP ABTEG ABTKH ABTMW ABULA ABWNU ABXPI ACAOD ACDTI ACGFS ACHSB ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACZOJ ADHHG ADHIR ADINQ ADJJI ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFQL AEGAL AEGNC AEJHL AEJRE AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGJBK AGMZJ AGQEE AGQMX AGRTI AGWZB AGYKE AHAVH AHBYD AHIZS AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALFXC ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR ANMIH AOCGG AUKKA AXYYD B-. BA0 BDATZ BGNMA CAG COF CS3 CSCUP D-I DDRTE DNIVK DPUIP EBLON EBS EIOEI EJD EN4 ESBYG F5P FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HF~ HG5 HG6 HLICF HMJXF HQYDN HRMNR HZ~ I0C IJ- IKXTQ IMOTQ IWAJR IXC IXD IZIGR IZQ I~X J-C J0Z JBSCW JCJTX JZLTJ KOV KPH LLZTM M4Y MA- NPVJJ NQJWS NU0 O9- O93 O9I O9J OAM P9S PT4 QOR QOS R89 RLLFE ROL RSV S16 S1Z S27 S37 S3B SAP SDH SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZ9 T13 TSG TSK TT1 U2A U9L UG4 UOJIU UTJUX UZXMN VC2 VFIZW W48 WK8 YLTOR Z45 Z7U Z82 Z87 ZMTXR ZOVNA ~A9 7X7 8FI AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC AEZWR AFDZB AFFHD AFHIU AFKRA AFOHR AHPBZ AHWEU AIXLP ATHPR AYFIA BENPR CCPQU CITATION FYUFA HMCUK M1P PHGZM PHGZT PJZUB PPXIY PSQYO UKHRP CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c446t-b0b78fce634f4a84ddacd1fe71a086863a58fb6ed7ce5c205fc301a0d7b448523 |
| IEDL.DBID | RSV |
| ISICitedReferencesCount | 17 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000725419300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1937-5387 1937-5395 |
| IngestDate | Tue Nov 04 02:06:10 EST 2025 Sun Nov 09 11:16:03 EST 2025 Mon Jul 21 05:55:42 EDT 2025 Sat Nov 29 06:11:43 EST 2025 Tue Nov 18 22:39:22 EST 2025 Fri Feb 21 02:46:48 EST 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | Thrombogenicity Computational fluid dynamics (CFD) Paravalvular leakage (PVL) Transcatheter aortic valve replacement (TAVR) Bicuspid aortic valve (BAV) Transcatheter aortic valve implantation (TAVI) Patient-specific computational modeling |
| Language | English |
| License | 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c446t-b0b78fce634f4a84ddacd1fe71a086863a58fb6ed7ce5c205fc301a0d7b448523 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Lead Author: Salwa Anam |
| ORCID | 0000-0002-4014-2308 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/9160219 |
| PMID | 34859367 |
| PQID | 2606923015 |
| PQPubID | 23479 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_9160219 proquest_miscellaneous_2606923015 pubmed_primary_34859367 crossref_citationtrail_10_1007_s12265_021_10191_z crossref_primary_10_1007_s12265_021_10191_z springer_journals_10_1007_s12265_021_10191_z |
| PublicationCentury | 2000 |
| PublicationDate | 2022-08-01 |
| PublicationDateYYYYMMDD | 2022-08-01 |
| PublicationDate_xml | – month: 08 year: 2022 text: 2022-08-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Journal of cardiovascular translational research |
| PublicationTitleAbbrev | J. of Cardiovasc. Trans. Res |
| PublicationTitleAlternate | J Cardiovasc Transl Res |
| PublicationYear | 2022 |
| Publisher | Springer US |
| Publisher_xml | – name: Springer US |
| References | Braghiroli, Kapoor, Thielhelm, Ferreira, Cohen (CR6) 2020; 10 Mack (CR36) 2015; 385 Wang, Kodali, Primiano, Sun (CR21) 2015; 14 Mauri (CR13) 2020; 7 Bosi (CR22) 2020; 10 Bianchi (CR26) 2016; 40 Pibarot, Clavel (CR4) 2017; 19 Spears, Al-Saiegh, Goldberg, Manthey, Goldberg (CR8) 2020; 2020 CR10 de Jaegere (CR20) 2016; 9 Conte (CR11) 2019; 1 Ward (CR3) 2000; 83 Mao, Wang, Kodali, Sun (CR18) 2018; 140 Huded (CR16) 2019; 321 Chiu (CR31) 2014; 136 Mas-Peiro, Fichtlscherer, Walther, Vasa-Nicotera (CR34) 2020; 12 Yoon (CR37) 2020; 76 Lavon (CR23) 2019; 57 Halim (CR12) 2020; 141 Pibarot, Hahn Rebecca, Weissman Neil, Monaghan Mark (CR32) 2015; 8 CR7 Vincent (CR9) 2021; 143 Qin (CR19) 2020; 17 Girdhar (CR30) 2012; 7 Martin, Sun (CR27) 2012; 100A Jimenez Diaz (CR14) 2019; 12 Emendi (CR28) 2021; 49 Jones (CR35) 2016; 152 Braverman (CR1) 2005; 30 Xenos (CR29) 2010; 43 Losenno, Goodman, Chu (CR2) 2012; 2012 Forrest (CR33) 2020; 13 Depboylu, Yazman, Harmandar (CR5) 2018; 2 Makkar (CR17) 2019; 321 Pasta (CR24) 2020; 58 Bianchi (CR15) 2019; 18 Dowling, Firoozi, Brecker (CR25) 2020; 13 V Mauri (10191_CR13) 2020; 7 C Ward (10191_CR3) 2000; 83 T Qin (10191_CR19) 2020; 17 RR Makkar (10191_CR17) 2019; 321 KL Losenno (10191_CR2) 2012; 2012 AC Braverman (10191_CR1) 2005; 30 SM Conte (10191_CR11) 2019; 1 M Xenos (10191_CR29) 2010; 43 J Braghiroli (10191_CR6) 2020; 10 S Mas-Peiro (10191_CR34) 2020; 12 M Bianchi (10191_CR15) 2019; 18 P Pibarot (10191_CR4) 2017; 19 K Lavon (10191_CR23) 2019; 57 S Pasta (10191_CR24) 2020; 58 SA Halim (10191_CR12) 2020; 141 10191_CR10 BM Jones (10191_CR35) 2016; 152 VA Jimenez Diaz (10191_CR14) 2019; 12 M Bianchi (10191_CR26) 2016; 40 BC Depboylu (10191_CR5) 2018; 2 MJ Mack (10191_CR36) 2015; 385 G Girdhar (10191_CR30) 2012; 7 C Dowling (10191_CR25) 2020; 13 C Martin (10191_CR27) 2012; 100A S-H Yoon (10191_CR37) 2020; 76 J Spears (10191_CR8) 2020; 2020 F Vincent (10191_CR9) 2021; 143 WC Chiu (10191_CR31) 2014; 136 W Mao (10191_CR18) 2018; 140 JK Forrest (10191_CR33) 2020; 13 10191_CR7 P de Jaegere (10191_CR20) 2016; 9 M Emendi (10191_CR28) 2021; 49 GM Bosi (10191_CR22) 2020; 10 P Pibarot (10191_CR32) 2015; 8 CP Huded (10191_CR16) 2019; 321 Q Wang (10191_CR21) 2015; 14 |
| References_xml | – volume: 19 start-page: 9 year: 2017 end-page: 11 ident: CR4 article-title: Outcome of aortic valve replacement in aortic stenosis: The number of valve cusps matters publication-title: European Heart Journal - Cardiovascular Imaging doi: 10.1093/ehjci/jex258 – volume: 13 start-page: 184 year: 2020 end-page: 192 ident: CR25 article-title: First-in-human experience with patient-specific computer simulation of TAVR in bicuspid aortic valve morphology publication-title: JACC: Cardiovascular Interventions doi: 10.1016/j.jcin.2019.07.032 – volume: 2012 start-page: 145202 year: 2012 ident: CR2 article-title: Bicuspid aortic valve disease and ascending aortic aneurysms: Gaps in knowledge publication-title: Cardiology Research and Practice doi: 10.1155/2012/145202 – volume: 1 start-page: 702 issue: 696 year: 2019 ident: CR11 article-title: Plugging paravalvular leak in transcatheter aortic valves publication-title: JACC: Case Reports doi: 10.1016/j.jaccas.2019.10.013 – volume: 12 start-page: 32 issue: 22 year: 2019 ident: CR14 article-title: Assessment of platelet REACtivity after transcatheter aortic valve replacement: The REAC-TAVI trial publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2018.10.005 – volume: 7 year: 2020 ident: CR13 article-title: Impact of device landing zone calcification patterns on paravalvular regurgitation after transcatheter aortic valve replacement with different next-generation devices publication-title: Open Heart doi: 10.1136/openhrt-2019-001164 – volume: 18 start-page: 435 year: 2019 end-page: 451 ident: CR15 article-title: Patient-specific simulation of transcatheter aortic valve replacement: Impact of deployment options on paravalvular leakage publication-title: Biomechanics and Modeling in Mechanobiology doi: 10.1007/s10237-018-1094-8 – ident: CR10 – volume: 12 start-page: 1665 year: 2020 end-page: 1680 ident: CR34 article-title: Current issues in transcatheter aortic valve replacement publication-title: Journal of thoracic disease doi: 10.21037/jtd.2020.01.10 – volume: 152 start-page: 783 year: 2016 end-page: 790 ident: CR35 article-title: Prognostic significance of mild aortic regurgitation in predicting mortality after transcatheter aortic valve replacement publication-title: Journal of Thoracic and Cardiovascular Surgery doi: 10.1016/j.jtcvs.2016.05.023 – volume: 143 start-page: 1043 year: 2021 end-page: 1061 ident: CR9 article-title: Transcatheter aortic valve replacement in bicuspid aortic valve stenosis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.048048 – volume: 43 start-page: 2400 year: 2010 end-page: 2409 ident: CR29 article-title: Device thrombogenicity emulator (DTE) — Design optimization methodology for cardiovascular devices: A study in two bileaflet MHV designs publication-title: Journal of Biomechanics doi: 10.1016/j.jbiomech.2010.04.020 – volume: 321 start-page: 2193 year: 2019 end-page: 2202 ident: CR17 article-title: Association between transcatheter aortic valve replacement for bicuspid vs tricuspid aortic stenosis and mortality or stroke publication-title: JAMA doi: 10.1001/jama.2019.7108 – volume: 13 start-page: 1749 year: 2020 end-page: 1759 ident: CR33 article-title: Transcatheter aortic valve replacement in bicuspid versus tricuspid aortic valves from the STS/ACC TVT Registry publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2020.03.022 – volume: 10 start-page: 9906 year: 2020 ident: CR22 article-title: A validated computational framework to predict outcomes in TAVI publication-title: Scientific Reports doi: 10.1038/s41598-020-66899-6 – volume: 58 start-page: 815 year: 2020 end-page: 829 ident: CR24 article-title: Simulation study of transcatheter heart valve implantation in patients with stenotic bicuspid aortic valve publication-title: Medical & Biological Engineering & Computing doi: 10.1007/s11517-020-02138-4 – volume: 30 start-page: 470 year: 2005 end-page: 522 ident: CR1 article-title: The bicuspid aortic valve publication-title: Curr Problems in Cardiology doi: 10.1016/j.cpcardiol.2005.06.002 – volume: 2 start-page: 26 year: 2018 ident: CR5 article-title: Complications of transcatheter aortic valve replacement and rescue attempts publication-title: Vessel Plus doi: 10.20517/2574-1209.2018.39 – volume: 14 start-page: 29 year: 2015 end-page: 38 ident: CR21 article-title: Simulations of transcatheter aortic valve implantation: Implications for aortic root rupture publication-title: Biomechanics and modeling in mechanobiology doi: 10.1007/s10237-014-0583-7 – volume: 7 start-page: e32463 year: 2012 ident: CR30 article-title: Device thrombogenicity emulation: A novel method for optimizing mechanical circulatory support device thromboresistance publication-title: PLoS One doi: 10.1371/journal.pone.0032463 – volume: 140 start-page: 1010071 year: 2018 end-page: 10100711 ident: CR18 article-title: Numerical parametric study of paravalvular leak following a transcatheter aortic valve deployment into a patient-specific aortic root publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4040457 – volume: 40 start-page: E292 year: 2016 end-page: e304 ident: CR26 article-title: Effect of balloon-expandable transcatheter aortic valve replacement positioning: A patient-specific numerical model publication-title: Artificial Organs doi: 10.1111/aor.12806 – volume: 141 start-page: 1071 year: 2020 end-page: 1079 ident: CR12 article-title: Outcomes of transcatheter aortic valve replacement in patients with bicuspid aortic valve disease publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.119.040333 – volume: 100A start-page: 1591 year: 2012 end-page: 1599 ident: CR27 article-title: Biomechanical characterization of aortic valve tissue in humans and common animal models publication-title: Journal of Biomedical Materials Research Part A doi: 10.1002/jbm.a.34099 – volume: 9 start-page: 512 issue: 508 year: 2016 ident: CR20 article-title: Patient-specific computer modeling to predict aortic regurgitation after transcatheter aortic valve replacement publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2016.01.003 – volume: 83 start-page: 81 year: 2000 ident: CR3 article-title: Clinical significance of the bicuspid aortic valve publication-title: Heart doi: 10.1136/heart.83.1.81 – volume: 8 start-page: 340 year: 2015 end-page: 360 ident: CR32 article-title: Assessment of paravalvular regurgitation following TAVR publication-title: JACC: Cardiovascular Imaging doi: 10.1016/j.jcmg.2015.01.008 – volume: 321 start-page: 2306 year: 2019 end-page: 2315 ident: CR16 article-title: Association between transcatheter aortic valve replacement and early postprocedural stroke publication-title: JAMA doi: 10.1001/jama.2019.7525 – volume: 76 start-page: 1018 year: 2020 end-page: 1030 ident: CR37 article-title: Bicuspid aortic valve morphology and outcomes after transcatheter aortic valve replacement publication-title: Journal of the American College of Cardiology doi: 10.1016/j.jacc.2020.07.005 – ident: CR7 – volume: 17 start-page: 20190893 year: 2020 ident: CR19 article-title: The role of stress concentration in calcified bicuspid aortic valve publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2019.0893 – volume: 136 start-page: 021014 year: 2014 ident: CR31 article-title: Thromboresistance comparison of the heartmate II ventricular assist device with the device thrombogenicity emulation-optimized heartassist 5 VAD publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4026254 – volume: 385 start-page: 2477 year: 2015 end-page: 2484 ident: CR36 article-title: 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): A randomised controlled trial publication-title: Lancet doi: 10.1016/s0140-6736(15)60308-7 – volume: 2020 start-page: 2582938 year: 2020 ident: CR8 article-title: TAVR: A review of current practices and considerations in low-risk patients publication-title: Journal of Interventional Cardiology doi: 10.1155/2020/2582938 – volume: 10 start-page: 59 year: 2020 end-page: 71 ident: CR6 article-title: Transcatheter aortic valve replacement in low risk patients: a review of PARTNER 3 and Evolut low risk trials publication-title: Cardiovascular diagnosis and therapy doi: 10.21037/cdt.2019.09.12 – volume: 49 start-page: 627 year: 2021 end-page: 641 ident: CR28 article-title: Patient-specific bicuspid aortic valve biomechanics: A magnetic resonance imaging integrated fluid–structure interaction approach publication-title: Annals of Biomedical Engineering doi: 10.1007/s10439-020-02571-4 – volume: 57 start-page: 2129 year: 2019 end-page: 2143 ident: CR23 article-title: Biomechanical modeling of transcatheter aortic valve replacement in a stenotic bicuspid aortic valve: Deployments and paravalvular leakage publication-title: Medical & biological engineering & computing doi: 10.1007/s11517-019-02012-y – volume: 140 start-page: 1010071 year: 2018 ident: 10191_CR18 publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4040457 – volume: 143 start-page: 1043 year: 2021 ident: 10191_CR9 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.120.048048 – volume: 13 start-page: 1749 year: 2020 ident: 10191_CR33 publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2020.03.022 – volume: 19 start-page: 9 year: 2017 ident: 10191_CR4 publication-title: European Heart Journal - Cardiovascular Imaging doi: 10.1093/ehjci/jex258 – ident: 10191_CR7 – volume: 57 start-page: 2129 year: 2019 ident: 10191_CR23 publication-title: Medical & biological engineering & computing doi: 10.1007/s11517-019-02012-y – volume: 13 start-page: 184 year: 2020 ident: 10191_CR25 publication-title: JACC: Cardiovascular Interventions doi: 10.1016/j.jcin.2019.07.032 – volume: 385 start-page: 2477 year: 2015 ident: 10191_CR36 publication-title: Lancet doi: 10.1016/s0140-6736(15)60308-7 – volume: 76 start-page: 1018 year: 2020 ident: 10191_CR37 publication-title: Journal of the American College of Cardiology doi: 10.1016/j.jacc.2020.07.005 – volume: 9 start-page: 512 issue: 508 year: 2016 ident: 10191_CR20 publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2016.01.003 – volume: 12 start-page: 1665 year: 2020 ident: 10191_CR34 publication-title: Journal of thoracic disease doi: 10.21037/jtd.2020.01.10 – volume: 7 year: 2020 ident: 10191_CR13 publication-title: Open Heart doi: 10.1136/openhrt-2019-001164 – volume: 83 start-page: 81 year: 2000 ident: 10191_CR3 publication-title: Heart doi: 10.1136/heart.83.1.81 – volume: 136 start-page: 021014 year: 2014 ident: 10191_CR31 publication-title: Journal of Biomechanical Engineering doi: 10.1115/1.4026254 – volume: 10 start-page: 9906 year: 2020 ident: 10191_CR22 publication-title: Scientific Reports doi: 10.1038/s41598-020-66899-6 – volume: 100A start-page: 1591 year: 2012 ident: 10191_CR27 publication-title: Journal of Biomedical Materials Research Part A doi: 10.1002/jbm.a.34099 – volume: 152 start-page: 783 year: 2016 ident: 10191_CR35 publication-title: Journal of Thoracic and Cardiovascular Surgery doi: 10.1016/j.jtcvs.2016.05.023 – volume: 1 start-page: 702 issue: 696 year: 2019 ident: 10191_CR11 publication-title: JACC: Case Reports doi: 10.1016/j.jaccas.2019.10.013 – volume: 17 start-page: 20190893 year: 2020 ident: 10191_CR19 publication-title: Journal of The Royal Society Interface doi: 10.1098/rsif.2019.0893 – volume: 2020 start-page: 2582938 year: 2020 ident: 10191_CR8 publication-title: Journal of Interventional Cardiology doi: 10.1155/2020/2582938 – ident: 10191_CR10 – volume: 40 start-page: E292 year: 2016 ident: 10191_CR26 publication-title: Artificial Organs doi: 10.1111/aor.12806 – volume: 321 start-page: 2193 year: 2019 ident: 10191_CR17 publication-title: JAMA doi: 10.1001/jama.2019.7108 – volume: 49 start-page: 627 year: 2021 ident: 10191_CR28 publication-title: Annals of Biomedical Engineering doi: 10.1007/s10439-020-02571-4 – volume: 2012 start-page: 145202 year: 2012 ident: 10191_CR2 publication-title: Cardiology Research and Practice doi: 10.1155/2012/145202 – volume: 30 start-page: 470 year: 2005 ident: 10191_CR1 publication-title: Curr Problems in Cardiology doi: 10.1016/j.cpcardiol.2005.06.002 – volume: 141 start-page: 1071 year: 2020 ident: 10191_CR12 publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.119.040333 – volume: 12 start-page: 32 issue: 22 year: 2019 ident: 10191_CR14 publication-title: JACC Cardiovascular Interventions doi: 10.1016/j.jcin.2018.10.005 – volume: 10 start-page: 59 year: 2020 ident: 10191_CR6 publication-title: Cardiovascular diagnosis and therapy doi: 10.21037/cdt.2019.09.12 – volume: 14 start-page: 29 year: 2015 ident: 10191_CR21 publication-title: Biomechanics and modeling in mechanobiology doi: 10.1007/s10237-014-0583-7 – volume: 2 start-page: 26 year: 2018 ident: 10191_CR5 publication-title: Vessel Plus doi: 10.20517/2574-1209.2018.39 – volume: 58 start-page: 815 year: 2020 ident: 10191_CR24 publication-title: Medical & Biological Engineering & Computing doi: 10.1007/s11517-020-02138-4 – volume: 8 start-page: 340 year: 2015 ident: 10191_CR32 publication-title: JACC: Cardiovascular Imaging doi: 10.1016/j.jcmg.2015.01.008 – volume: 321 start-page: 2306 year: 2019 ident: 10191_CR16 publication-title: JAMA doi: 10.1001/jama.2019.7525 – volume: 43 start-page: 2400 year: 2010 ident: 10191_CR29 publication-title: Journal of Biomechanics doi: 10.1016/j.jbiomech.2010.04.020 – volume: 18 start-page: 435 year: 2019 ident: 10191_CR15 publication-title: Biomechanics and Modeling in Mechanobiology doi: 10.1007/s10237-018-1094-8 – volume: 7 start-page: e32463 year: 2012 ident: 10191_CR30 publication-title: PLoS One doi: 10.1371/journal.pone.0032463 |
| SSID | ssj0062077 |
| Score | 2.3873715 |
| Snippet | Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates asymmetric flow patterns and increased stresses on the leaflets that... BAV, the most common congenital valvular abnormality, generate asymmetric flow patterns and increased stresses on the leaflets that expedite valvular... |
| SourceID | pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 834 |
| SubjectTerms | Aortic Valve - diagnostic imaging Aortic Valve - surgery Aortic Valve Stenosis - surgery Bicuspid Aortic Valve Disease Biomedical Engineering and Bioengineering Biomedicine Cardiology Computer Simulation Human Genetics Humans Medicine Medicine & Public Health Original Article Patient-Specific Modeling Transcatheter Aortic Valve Replacement - adverse effects Treatment Outcome |
| Title | Assessment of Paravalvular Leak Severity and Thrombogenic Potential in Transcatheter Bicuspid Aortic Valve Replacements Using Patient-Specific Computational Modeling |
| URI | https://link.springer.com/article/10.1007/s12265-021-10191-z https://www.ncbi.nlm.nih.gov/pubmed/34859367 https://www.proquest.com/docview/2606923015 https://pubmed.ncbi.nlm.nih.gov/PMC9160219 |
| Volume | 15 |
| WOSCitedRecordID | wos000725419300002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLINK Contemporary 1997-Present customDbUrl: eissn: 1937-5395 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0062077 issn: 1937-5387 databaseCode: RSV dateStart: 20080301 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JbtswEB00aVHk0nTJoi7GFOitJaDNIn10ixg9tIFRp4ZvAsUFEZJIhmXnkP_Jf3ZISw7cFAHSiy6iSIl8JN-IM28APkXCFoYMCxbryDCyNxQTVgkW8qJvTSxFYoVPNsFPT8VsNhi3QWFN5-3eHUn6lfou2I2Ygosmdi5YZGWwmx14StudcNPx12Tarb9ZHPp8i8RMOKPpzNtQmX_Xsb0d3eOY910l_zov9dvQaP__PuAlvGhpJw7XOHkFT0z1Gp7_bA_W38DtcKPQibXFsVxIguC181HFH0Ze4MQQ5omxo6w0np0v6quiJuyVCsf10nkcUe1lhX7r81KwNF74tVSrZl5qHNauYZxSlQaJ87t_9z62Dr3LArXn1V3ZZG68jyCuk020PyrRJWxzYfMH8Ht0cvbtO2szODBFw75kRVhwGnqTJalNpUi1lkpH1vBIkiklskT2CSuZ0VyZvorDvlW04MhQ84LMRrKRD2G3qitzDCiFikSohNWFTuPQylDyhC6ZS8XHVRpA1A1krlp5c5dl4zK_E2Z2_Z9T_-e-__ObAD5vnpmvxT0eLP2xw0dOc9AdrMjK1KsmJ5swI6JMzCqAozVeNvUlqVOUy3gAfAtJmwJO33v7TlWee51vYu7U_CCALx2e8naBaR54zbePK_4O9mIX0eF9Gt_D7nKxMh_gmbpels2iBzt8Jnp-fv0BzacksQ |
| linkProvider | Springer Nature |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB5BQcCFZynhOUjcwFJeG7vHBVEVsV2t2KXqzXL8UCNostrs9tD_w_9k7E22WooqwSWXOHZif7Zn4m--AXiXCFdacixYahLLyN_QTDgtWMzLgbOpEpkTIdkEH4_Fycn-pAsKa3u2e38kGVbqy2A3shR8NLGnYJGXwS5uwq2cdixP5Ps2Pe7X3yKNQ75Fskw4o-nMu1CZv9exvR1dsTGvUiX_OC8N29DBg__7gIdwvzM7cbjGySO4YevHcOeoO1h_Ar-GG4VObBxO1EIRBM89RxVHVv3AqSXMk8WOqjY4O100Z2VD2Ks0TpqlZxxR7VWNYesLUrA0Xvix0qt2XhkcNr5hPKYqLZLN7__dh9g6DJQFai-ou7Lp3AaOIK6TTXQ_KtEnbPNh87vw_eDz7NMh6zI4ME3DvmRlXHIaeltkucuVyI1R2iTO8kSRKyWKTA0IK4U1XNuBTuOB07TgqNjwktxG8pGfwk7d1PYZoBI6EbEWzpQmT2OnYsUzuhQ-FR_XeQRJP5BSd_LmPsvGT3kpzOz7X1L_y9D_8iKC95tn5mtxj2tLv-3xIWkO-oMVVdtm1UryCQsylMmyimBvjZdNfVnuFeUKHgHfQtKmgNf33r5TV6dB55ssd2p-P4IPPZ5kt8C017zm838r_gbuHs6ORnL0Zfz1BdxLfXRH4De-hJ3lYmVfwW19vqzaxeswy34DpvwmrQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BQRUX3pS0PIzEDazmtbF7XB4rEGW10paqN8vxQ40oyWofPfT_8D-ZcZItS1ElxCWXOLZjf7ZnPDPfALxOpC8dKhY8tYnjqG8YLr2RPBblwLtUy8zLkGxCjMfy5ORg8lsUf_B2702SbUwDsTTVy_2Z9fuXgW8oNVBkMbljocbBL27CrZySBpG-Pj3u9-IijUPuRZRSBMelLbqwmb_XsXk0XZE3r7pN_mE7DUfS6N7__8x9uNuJo2zY4ucB3HD1Q9j-2hncH8HP4Zq5kzWeTfRcIzTPyXeVHTr9nU0drgWU5JmuLTs6nTc_ygYxWRk2aagPCG9W1SwciYEiFueRvavMajGrLBs21DA7xiodQ12A7vRDzB0LrgzYXmB95dOZC76DrE1C0V1gMkrkRuH0j-Hb6OPR-0-8y-zADcJhycu4FAgJV2S5z7XMrdXGJt6JROMcyiLTA8RQ4awwbmDSeOANbkQ6tqJEdRJ15yewVTe1ewpMS5PI2EhvS5unsdexFhk-CkrRJ0weQdJPqjId7Tll3zhTl4TNNP4Kx1-F8VcXEbxZfzNrST-uLf2qx4rCtUkGF127ZrVQqCsWKECjxBXBTouddX1ZTkxzhYhAbKBqXYB4vzff1NVp4P9GiR6bP4jgbY8t1W08i2u6uftvxV_C9uTDSB1-Hn_ZgzspBX0Et8dnsLWcr9xzuG3Ol9Vi_iIsuF-qCi-R |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Assessment+of+Paravalvular+Leak+Severity+and+Thrombogenic+Potential+in+Transcatheter+Bicuspid+Aortic+Valve+Replacements+Using+Patient-Specific+Computational+Modeling&rft.jtitle=Journal+of+cardiovascular+translational+research&rft.au=Anam%2C+Salwa+B.&rft.au=Kovarovic%2C+Brandon+J.&rft.au=Ghosh%2C+Ram+P.&rft.au=Bianchi%2C+Matteo&rft.date=2022-08-01&rft.issn=1937-5387&rft.eissn=1937-5395&rft.volume=15&rft.issue=4&rft.spage=834&rft.epage=844&rft_id=info:doi/10.1007%2Fs12265-021-10191-z&rft.externalDBID=n%2Fa&rft.externalDocID=10_1007_s12265_021_10191_z |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1937-5387&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1937-5387&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1937-5387&client=summon |