Daunorubicin and doxorubicin but not BCNU have deleterious effects on organotypic multicellular spheroids of gliomas

In the present study organotypic multicellular spheroids (OMS) were used to study the effects of chemotherapeutic agents on malignant gliomas. Compared with the frequently used cell line models, OMS have several advantages with respect to the preservation of the cellular heterogeneity and the struct...

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Bibliographic Details
Published in:	British journal of cancer Vol. 74; no. 2; p. 187
Main Authors:	Kaaijk, P, Troost, D, de Boer, O J, Van Amstel, P, Bakker, P J, Leenstra, S, Bosch, D A
Format:	Journal Article
Language:	English
Published:	England 01.07.1996
Subjects:	Antibiotics, Antineoplastic - pharmacology Antineoplastic Agents, Alkylating - pharmacology ATP Binding Cassette Transporter, Subfamily B, Member 1 - analysis ATP-Binding Cassette Transporters - analysis Brain Neoplasms - chemistry Brain Neoplasms - drug therapy Brain Neoplasms - pathology Carmustine - pharmacology Cell Division - drug effects Daunorubicin - pharmacology Doxorubicin - pharmacology Drug Screening Assays, Antitumor Glioma - chemistry Glioma - drug therapy Glioma - pathology Humans Immunohistochemistry Multidrug Resistance-Associated Proteins Spheroids, Cellular - drug effects Tumor Cells, Cultured
ISSN:	0007-0920
Online Access:	Get more information
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